Results 11 to 20 of about 3,585 (189)

A Cooperative Mechanism Involving Ca2+-Permeable AMPA Receptors and Retrograde Activation of GABAB Receptors in Interpeduncular Nucleus Plasticity [PDF]

Cell Reports, 2017
Summary: The medial habenula-interpeduncular nucleus (MHb-IPN) pathway, which connects the limbic forebrain to the midbrain, has recently been implicated in aversive behaviors.
Peter Koppensteiner, Riccardo Melani, Ipe Ninan   +2 more
exaly   +5 more sources

The interpeduncular nucleus blunts the rewarding effect of nicotine. [PDF]

Neuron, 2023
Summary Nicotine, by stimulating ventral tegmental area (VTA) dopaminergic neurons, has a rewarding effect that drives tobacco consumption. In turn, the interpeduncular nucleus (IPN) is thought to become activated at high nicotine doses to restrict drug intake. However, the dynamics of the IPN response to nicotine and
Jehl J, Ciscato M, Vicq E, Guyon N, Dejean de la Batie G, Mondoloni S, Frangieh J, Mohayyaei M, Nguyen C, Pons S, Maskos U, Hardelin JP, Marti F, Corringer PJ, Faure P, Mourot A.   +15 more
europepmc   +5 more sources

Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion [PDF]

Nature Communications, 2022
Appropriate processing of value information is essential for survival. Here the authors show that in mice, serotonergic activations originating from the median raphe nucleus facilitated aversion in a pathway-dependent manner, while silencing this pathway
Hiroyuki Kawai, Youcef Bouchekioua, Naoya Nishitani, Kazuhei Niitani, Shoma Izumi, Hinako Morishita, Chihiro Andoh, Yuma Nagai, Masashi Koda, Masako Hagiwara, Koji Toda, Hisashi Shirakawa, Kazuki Nagayasu, Yu Ohmura, Makoto Kondo, Katsuyuki Kaneda, Mitsuhiro Yoshioka, Shuji Kaneko   +17 more
doaj   +3 more sources

Multiple Regionalized Genes and Their Putative Networks in the Interpeduncular Nucleus Suggest Complex Mechanisms of Neuron Development and Axon Guidance [PDF]

Frontiers in Neuroanatomy, 2021
The interpeduncular nucleus (IPN) is a highly conserved limbic structure in the vertebrate brain, located in the isthmus and rhombomere 1. It is formed by various populations that migrate from different sites to the distinct domains within the IPN: the ...
Isabel M. García-Guillén, Antonia Alonso, Luis Puelles, Faustino Marín, Pilar Aroca   +4 more
doaj   +4 more sources

Netrin-1/DCC Signaling Differentially Regulates the Migration of Pax7, Nkx6.1, Irx2, Otp, and Otx2 Cell Populations in the Developing Interpeduncular Nucleus [PDF]

Frontiers in Cell and Developmental Biology, 2020
The interpeduncular nucleus (IPN) is a hindbrain structure formed by three main subdivisions, the prodromal (Pro) domain located at the isthmus (Ist), and the rostral and caudal interpeduncular domains (IPR, IPC) within rhombomere 1 (r1).
Isabel M. García-Guillén, Isabel M. García-Guillén, Antonia Alonso, Antonia Alonso, Nicanor Morales-Delgado, Nicanor Morales-Delgado, Nicanor Morales-Delgado, Belén Andrés, Luis Puelles, Luis Puelles, Guillermina López-Bendito, Faustino Marín, Faustino Marín, Pilar Aroca, Pilar Aroca   +14 more
doaj   +4 more sources

Nicotinic Receptors in the Medial Habenula to Interpeduncular Nucleus Pathway: Modulators of Reward, Aversion and Emotion. [PDF]

Eur J Neurosci
ABSTRACT The medial habenula–interpeduncular nucleus pathway is a highly conserved and densely innervated brain circuit known for its unique cholinergic transmission and exceptional expression of nicotinic acetylcholine receptors. This pathway plays a critical role in regulating motivational and emotional processes, particularly those related to ...
Ciscato M, Chouvaeff M, Mourot A.
europepmc   +3 more sources

Prolonged nicotine exposure reduces aversion to the drug in mice by altering nicotinic transmission in the interpeduncular nucleus [PDF]

eLife, 2023
Nicotine intake is likely to result from a balance between the rewarding and aversive properties of the drug, yet the individual differences in neural activity that control aversion to nicotine and their adaptation during the addiction process remain ...
Sarah Mondoloni, Claire Nguyen, Eléonore Vicq, Maria Ciscato, Joachim Jehl, Romain Durand-de Cuttoli, Nicolas Torquet, Stefania Tolu, Stéphanie Pons, Uwe Maskos, Fabio Marti, Philippe Faure, Alexandre Mourot   +12 more
doaj   +2 more sources

Visual motion and landmark position align with heading direction in the zebrafish interpeduncular nucleus [PDF]

Nature Communications
Sensory information is fundamental for navigation. Visual motion is used by animals to estimate their traveling distance and direction, and landmarks allow animals to tether their location and orientation to their environment.
Hagar Lavian, Ot Prat, Luigi Petrucco, Vilim Štih, Ruben Portugues   +4 more
doaj   +2 more sources

Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum [PDF]

Nature Communications, 2018
Despite its known effects in brain reward centers, nicotine can be aversive in high doses. Here, the authors show that nicotine aversion depends on low-affinity nicotinic acetylcholine receptors expressed on projections from the interpeduncular nucleus ...
Shannon L. Wolfman, Daniel F. Gill, Fili Bogdanic, Katie Long, Ream Al-Hasani, Jordan G. McCall, Michael R. Bruchas, Daniel S. McGehee   +7 more
doaj   +2 more sources

Trans-Synaptic Virus Tracing Reveals Reciprocal Connections of the Interpeduncular Nucleus With the Mood, Exteroceptive, Interoceptive, and Motor Control Systems. [PDF]

J Comp Neurol
The interpeduncular nucleus (IPN) in zebrafish plays a pivotal role in directional decision‐making, social conflict, and fear responses. The anterograde and retrograde connections of the dorsal and intermediate IPN are revealed through the use of monosynaptic and trans‐synaptic viral tracers.
Wong AK, Cherng BW, Kakinuma H, Wyart C, Okamoto H.   +4 more
europepmc   +2 more sources