Results 11 to 20 of about 318,868 (184)

GABAB receptor-mediated potentiation of ventral medial habenula glutamatergic transmission in GABAergic and glutamatergic interpeduncular nucleus neurons [PDF]

IBRO Neuroscience Reports
The medial habenula (MHb)-interpeduncular nucleus (IPN) pathway plays a crucial role in information transferring between the forebrain and the midbrain, and has been implicated in the regulation of fear behavior and nicotine addiction.
Hannah E. Stinson, Ipe Ninan
doaj   +2 more sources

Nicotinic Receptors in the Medial Habenula to Interpeduncular Nucleus Pathway: Modulators of Reward, Aversion and Emotion. [PDF]

Eur J Neurosci
ABSTRACT The medial habenula–interpeduncular nucleus pathway is a highly conserved and densely innervated brain circuit known for its unique cholinergic transmission and exceptional expression of nicotinic acetylcholine receptors. This pathway plays a critical role in regulating motivational and emotional processes, particularly those related to ...
Ciscato M, Chouvaeff M, Mourot A.
europepmc   +2 more sources

Clarifying the Role of the Rostral Interpeduncular Nucleus in Aversion to Nicotine. [PDF]

J Neurosci, 2019
Genetic and environmental factors contribute to an individual's sensitivity to drug reward and aversion, thereby influencing their susceptibility to drug abuse and addiction. A genetic variant (D398N) in the gene CHRNA5 , which encodes the α5 subunit of the nicotinic acetylcholine receptor ...
Brynildsen JK.
europepmc   +4 more sources

Chemogenetic control of GABAergic neurons within the interpeduncular nucleus reveals dissociable behavioral components of the nicotine withdrawal phenotype [PDF]

Neurobiology of Disease
Chronic exposure to nicotine results in the development of a dependent state such that a withdrawal syndrome is elicited upon cessation of nicotine. The interpeduncular nucleus (IPN) contains a high concentration of nicotinic acetylcholine receptors ...
Anabel M.M. Miguelez Fernández, Shana Netherton, Seshadri B. Niladhuri, Alexander C. Brown, Patricia Rivera, Kuei Y. Tseng, Christian J. Peters   +6 more
doaj   +2 more sources

Abundant extrasynaptic expression of α3β4-containing nicotinic acetylcholine receptors in the medial habenula–interpeduncular nucleus pathway in mice [PDF]

Scientific Reports
Nicotinic acetylcholine receptors (nAChRs) in the medial habenula (MHb)–interpeduncular nucleus (IPN) pathway play critical roles in nicotine-related behaviors.
Asuka Tsuzuki, Miwako Yamasaki, Kohtarou Konno, Taisuke Miyazaki, Norio Takei, Susumu Tomita, Michisuke Yuzaki, Masahiko Watanabe   +7 more
doaj   +2 more sources

The Neural Distribution of Vasotocin, Oxytocin, Dopamine, and Serotonin in Two Australian Skinks With Contrasting Social Lives. [PDF]

J Comp Neurol
1. We investigated two skink species differing primarily in social ecology. 2. Using immunohistochemistry, we investigated the distribution of four neurotransmitters known to play a role in vertebrate social behavior. 3. We generally found these transmitters in more brain regions in the family‐living species.
Lake J, Whiting MJ, While GM, Kabelik D, Rubenstein DR, Hoops D.   +5 more
europepmc   +2 more sources

Shentong Zhuyu Decoction Alleviates Neuropathic Pain in Mice by Inhibiting the NMDAR-2B Receptor-Mediated CaMKII/CREB Signaling Pathway in GABAergic Neurons of the Interpeduncular Nucleus [PDF]

Pharmaceuticals
Background: Shentong Zhuyu Decoction (STZYD) is a traditional Chinese medicine formula that has shown promise in alleviating neuropathic pain (NPP), yet its central mechanisms remain unclear.
Ying Liu, Rujie Li, Haojie Cheng, Yuxin Wang, Jian Sun, Meiyu Zhang   +5 more
doaj   +2 more sources

Postnatal expression of the transcription factor Ebf2 in motivation, reward, and pain-related circuits of the mouse brain [PDF]

Frontiers in Neuroanatomy
IntroductionEarly B-cell factor 2 (Ebf2) is a transcription factor required for neuronal differentiation. However, its postnatal expression pattern and functional roles in the brain are not well characterized. This study examined the spatial distribution
Moisés Martínez-Estrada, Moisés Martínez-Estrada, M. Blanca D. Cepeda-Varela, A. Damaris Salinas-Villarreal, Mara C. Obregón-Fuentes, Danna A. Real-Marín, Melani A. Balderas-Díaz, Viviana Zomosa-Signoret, Jesús Santana-Solano, Moisés Santillán-Zerón, Román Vidaltamayo   +10 more
doaj   +2 more sources

Modulation of habenula axon terminals supports action-outcome associations in larval zebrafish [PDF]

Nature Communications
Improving behavioral performance relies on the ability to associate decisions with their positive and negative outcomes. Although neurons that associate actions with their consequences have been identified across multiple brain regions, the circuit-level
Emanuele Paoli, Virginia Palieri, Amey Shenoy, Ruben Portugues   +3 more
doaj   +2 more sources

α3* Nicotinic Acetylcholine Receptors in the Habenula-Interpeduncular Nucleus Circuit Regulate Nicotine Intake. [PDF]

J Neurosci, 2021
Allelic variation in CHRNA3, the gene encoding the α3 nicotinic acetylcholine receptor (nAChR) subunit, increases vulnerability to tobacco dependence and smoking-related diseases, but little is known about the role for α3-containing (α3*) nAChRs in ...
Elayouby KS, Ishikawa M, Dukes AJ, Smith ACW, Lu Q, Fowler CD, Kenny PJ.   +6 more
europepmc   +2 more sources