α3* Nicotinic Acetylcholine Receptors in the Habenula-Interpeduncular Nucleus Circuit Regulate Nicotine Intake. [PDF]
J Neurosci, 2021 Allelic variation in CHRNA3, the gene encoding the α3 nicotinic acetylcholine receptor (nAChR) subunit, increases vulnerability to tobacco dependence and smoking-related diseases, but little is known about the role for α3-containing (α3*) nAChRs in ...
Elayouby KS +6 more
europepmc +2 more sources
Complex opioid-driven modulation of glutamatergic and cholinergic neurotransmission in a GABAergic brain nucleus associated with emotion, reward, and addiction [PDF]
eLifeThe medial habenula (mHb)/interpeduncular nucleus (IPN) circuitry is resident to divergent molecular, neurochemical, and cellular components which, in concert, perform computations to drive emotion, reward, and addiction behaviors.
Ramesh Chittajallu +8 more
doaj +2 more sources
Dopamine control of social novelty preference is constrained by an interpeduncular-tegmentum circuit
Nature CommunicationsAnimals are inherently motivated to explore social novelty cues over familiar ones, resulting in a novelty preference (NP), although the behavioral and circuit bases underlying NP are unclear.
Susanna Molas +7 more
doaj +3 more sources
Dynamic activity of interpeduncular nucleus GABAergic neurons controls expression of nicotine withdrawal in male mice. [PDF]
Neuropsychopharmacology, 2022 A critical brain area implicated in nicotine dependence is the interpeduncular nucleus (IPN) located in the ventral midbrain and consisting primarily of GABAergic neurons.
Klenowski PM +4 more
europepmc +2 more sources
Viral Tracing Confirms Paranigral Ventral Tegmental Area Dopaminergic Inputs to the Interpeduncular Nucleus Where Dopamine Release Encodes Motivated Exploration. [PDF]
eNeuro, 2023 Midbrain dopaminergic (DAergic) neurons of the ventral tegmental area (VTA) are engaged by rewarding stimuli and encode reward prediction error to update goal-directed learning.
Molas S +3 more
europepmc +2 more sources
Manganese-Enhanced MRI Reflects Both Activity-Independent and Activity-Dependent Uptake within the Rat Habenulomesencephalic Pathway. [PDF]
PLoS ONE, 2015 Manganese-enhanced magnetic resonance imaging (MEMRI) is a powerful technique for assessing the functional connectivity of neurons within the central nervous system. Despite the widely held proposition that MEMRI signal is dependent on neuronal activity,
Leiming Wang +7 more
doaj +1 more source
The medial habenula and interpeduncular nucleus circuitry is critical in addiction, anxiety, and mood regulation [PDF]
Journal of Neurochemistry, 2017 John A Dani, Mariella De Biasi
exaly +2 more sources
Specialized neurons in the right habenula mediate response to aversive olfactory cues
eLife, 2021 Hemispheric specializations are well studied at the functional level but less is known about the underlying neural mechanisms. We identified a small cluster of cholinergic neurons in the dorsal habenula (dHb) of zebrafish, defined by their expression of ...
Jung-Hwa Choi +4 more
doaj +1 more source
Expression of Urocortin 3 mRNA in the Central Nervous System of the Sea Lamprey Petromyzon marinus
Biology, 2021 In this study, we analyzed the organization of urocortin 3 (Ucn3)-expressing neuronal populations in the brain of the adult sea lamprey by means of in situ hybridization.
Daniel Sobrido-Cameán +2 more
doaj +1 more source
Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. [PDF]
Nat Commun, 2015 Increased anxiety is a prominent withdrawal symptom in abstinent smokers, yet the neuroanatomical and molecular bases underlying it are unclear.
Zhao-Shea R +11 more
europepmc +2 more sources