Complex opioid-driven modulation of glutamatergic and cholinergic neurotransmission in a GABAergic brain nucleus associated with emotion, reward, and addiction [PDF]
eLifeThe medial habenula (mHb)/interpeduncular nucleus (IPN) circuitry is resident to divergent molecular, neurochemical, and cellular components which, in concert, perform computations to drive emotion, reward, and addiction behaviors.
Ramesh Chittajallu +8 more
doaj +2 more sources
Manganese-Enhanced MRI Reflects Both Activity-Independent and Activity-Dependent Uptake within the Rat Habenulomesencephalic Pathway. [PDF]
PLoS ONE, 2015 Manganese-enhanced magnetic resonance imaging (MEMRI) is a powerful technique for assessing the functional connectivity of neurons within the central nervous system. Despite the widely held proposition that MEMRI signal is dependent on neuronal activity,
Leiming Wang +7 more
doaj +1 more source
Specialized neurons in the right habenula mediate response to aversive olfactory cues
eLife, 2021 Hemispheric specializations are well studied at the functional level but less is known about the underlying neural mechanisms. We identified a small cluster of cholinergic neurons in the dorsal habenula (dHb) of zebrafish, defined by their expression of ...
Jung-Hwa Choi +4 more
doaj +1 more source
The medial habenula and interpeduncular nucleus circuitry is critical in addiction, anxiety, and mood regulation [PDF]
Journal of Neurochemistry, 2017 John Dani, Mariella de Biasi
exaly +2 more sources
Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. [PDF]
Nat Commun, 2015 Increased anxiety is a prominent withdrawal symptom in abstinent smokers, yet the neuroanatomical and molecular bases underlying it are unclear.
Zhao-Shea R +11 more
europepmc +2 more sources
Expression of Urocortin 3 mRNA in the Central Nervous System of the Sea Lamprey Petromyzon marinus
Biology, 2021 In this study, we analyzed the organization of urocortin 3 (Ucn3)-expressing neuronal populations in the brain of the adult sea lamprey by means of in situ hybridization.
Daniel Sobrido-Cameán +2 more
doaj +1 more source
Differences in the localization and morphology of chromosomes in the human nucleus [PDF]
, 1999 Using fluorescence in situ hybridization we show striking differences in nuclear position, chromosome morphology, and interactions with nuclear substructure for human chromosomes 18 and 19.
Perry, P +5 more
core +7 more sources
Integrated miRNA-/mRNA-Seq of the Habenulo-Interpeduncular Circuit During Acute Nicotine Withdrawal
Scientific Reports, 2020 Tobacco use is the leading preventable cause of mortality in the world. The limited number of smoking cessation aids currently available are minimally effective, highlighting the need for novel therapeutic interventions.
Alison P. Casserly +7 more
doaj +1 more source
GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals
eLife, 2021 The synaptic connection from medial habenula (MHb) to interpeduncular nucleus (IPN) is critical for emotion-related behaviors and uniquely expresses R-type Ca2+ channels (Cav2.3) and auxiliary GABAB receptor (GBR) subunits, the K+-channel tetramerization
Pradeep Bhandari +12 more
doaj +1 more source
Mapping of neurokinin-like immunoreactivity in the human brainstem
BMC Neuroscience, 2003 Background Using an indirect immunoperoxidase technique, we have studied the distribution of immunoreactive fibers and cell bodies containing neurokinin in the adult human brainstem with no prior history of neurological or psychiatric disease.
Narvaez Jose +10 more
doaj +1 more source