Results 1 to 10 of about 3,585 (189)

Medial Habenula-Interpeduncular Nucleus Circuit Contributes to Anhedonia-Like Behavior in a Rat Model of Depression [PDF]

Frontiers in Behavioral Neuroscience, 2018
The habenula is a nuclear complex composed of the lateral habenula (LHb) and medial habenula (MHb), two distinct structures. Much progress has been made to emphasize the role of the LHb in the pathogenesis of depression.
Chunpeng Xu, Yanfei Sun, Xuewei Cai, Tingting You, Hongzhe Zhao, Yang Li, Hua Zhao   +6 more
doaj   +4 more sources

Genetic dissection of medial habenula–interpeduncular nucleus pathway function in mice [PDF]

Frontiers in Behavioral Neuroscience, 2013
The habenular complex linking forebrain and midbrain structures is subdivided into the medial (mHb) and the lateral nuclei (lHb). The mHb is characterized by the expression of specific nicotinic acetylcholine receptor isoforms and the release of ...
Yuki eKobayashi, Yoshitake eSano, Elisabetta eVannoni, Hiromichi eGoto, Toshio eIkeda, Hitomi eSuzuki, Atsuko eOba, Hiroaki eKawasaki, Shigenobu eKanba, Hans-Peter eLipp, Niall P Murphy, David P Wolfer, Shigeyoshi eItohara   +12 more
doaj   +4 more sources

GABAB receptor-mediated potentiation of ventral medial habenula glutamatergic transmission in GABAergic and glutamatergic interpeduncular nucleus neurons [PDF]

IBRO Neuroscience Reports
The medial habenula (MHb)-interpeduncular nucleus (IPN) pathway plays a crucial role in information transferring between the forebrain and the midbrain, and has been implicated in the regulation of fear behavior and nicotine addiction.
Hannah E. Stinson, Ipe Ninan
doaj   +2 more sources

Clarifying the Role of the Rostral Interpeduncular Nucleus in Aversion to Nicotine. [PDF]

J Neurosci, 2019
Genetic and environmental factors contribute to an individual's sensitivity to drug reward and aversion, thereby influencing their susceptibility to drug abuse and addiction. A genetic variant (D398N) in the gene CHRNA5 , which encodes the α5 subunit of the nicotinic acetylcholine receptor ...
Brynildsen JK.
europepmc   +4 more sources

Abundant extrasynaptic expression of α3β4-containing nicotinic acetylcholine receptors in the medial habenula–interpeduncular nucleus pathway in mice [PDF]

Scientific Reports
Nicotinic acetylcholine receptors (nAChRs) in the medial habenula (MHb)–interpeduncular nucleus (IPN) pathway play critical roles in nicotine-related behaviors.
Asuka Tsuzuki, Miwako Yamasaki, Kohtarou Konno, Taisuke Miyazaki, Norio Takei, Susumu Tomita, Michisuke Yuzaki, Masahiko Watanabe   +7 more
doaj   +2 more sources

Review: "The Disappointment Dilemma: Short- and Long-Term Learning From Negative Outcomes". [PDF]

Eur J Neurosci
The habenula routes negative‐outcome signals to VTA, RMTg, and IPN to shape aversive learning and motivation. The lateral habenula encodes acute negative prediction errors to rapidly adapt behavior to threat, fear, and avoidance. The medial habenula integrates repeated stress, drug, and aversive experiences into long‐term negative mood and expectations.
Ibañez-Tallon I, Molas S, Proulx CD, Piriz J, Soria-Gómez E.   +4 more
europepmc   +2 more sources

Shentong Zhuyu Decoction Alleviates Neuropathic Pain in Mice by Inhibiting the NMDAR-2B Receptor-Mediated CaMKII/CREB Signaling Pathway in GABAergic Neurons of the Interpeduncular Nucleus [PDF]

Pharmaceuticals
Background: Shentong Zhuyu Decoction (STZYD) is a traditional Chinese medicine formula that has shown promise in alleviating neuropathic pain (NPP), yet its central mechanisms remain unclear.
Ying Liu, Rujie Li, Haojie Cheng, Yuxin Wang, Jian Sun, Meiyu Zhang   +5 more
doaj   +2 more sources

Postnatal expression of the transcription factor Ebf2 in motivation, reward, and pain-related circuits of the mouse brain [PDF]

Frontiers in Neuroanatomy
IntroductionEarly B-cell factor 2 (Ebf2) is a transcription factor required for neuronal differentiation. However, its postnatal expression pattern and functional roles in the brain are not well characterized. This study examined the spatial distribution
Moisés Martínez-Estrada, Moisés Martínez-Estrada, M. Blanca D. Cepeda-Varela, A. Damaris Salinas-Villarreal, Mara C. Obregón-Fuentes, Danna A. Real-Marín, Melani A. Balderas-Díaz, Viviana Zomosa-Signoret, Jesús Santana-Solano, Moisés Santillán-Zerón, Román Vidaltamayo   +10 more
doaj   +2 more sources

Neuromeric Organization of the Microbat Brain: Conserved and Distinct Regional Features. [PDF]

J Comp Neurol
The fundamental neuromeric modular plan is remarkably conserved across bats and rodents. However, there are significant regional differences in the size and organization of specific derivatives (A). In addition, both Tadarida brasiliensis and Myotis myotis share similar general patterns of TH‐positive processes and tracts in the basal plate of the ...
Lucero-Arteaga F, Abrego-Alvarez A, Clauzure M, Labegorra S, Heck V, Portu AI, Boeris MA, Mondino MA, Do-Couto BR, Tseng KY, García-Cabezas MÁ, Ferran JL.   +11 more
europepmc   +2 more sources

Distribution of mRNA for the exocytotic calcium sensor, synaptotagmin 9, in mouse brain [PDF]

IBRO Neuroscience Reports
The principal Ca2 + sensors that control fusion of synaptic vesicles are synaptotagmins 1, 2 and 9. Synaptotagmin 9 (Syt9) has received the least attention. We applied RNAscope techniques to coronal sections of adult mouse brain to study the distribution
Kwadwo O. Boateng, Lucian D. Hadford, Kelly L. Stauch, Anthony E. Kincaid, Wallace B. Thoreson   +4 more
doaj   +2 more sources