Results 71 to 80 of about 426,364 (268)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Characteristic Polynomial and Eigenproblem of Triangular Matrix over Interval Min-Plus Algebra

JTAM (Jurnal Teori dan Aplikasi Matematika)
A min-plus algebra is a linear algebra over the semiring R_ε', equipped with the operations “"⊕'=min" ” and “⊗=+”. In min-plus algebra, there is the concept of characteristic polynomial obtained from permanent of matrix.
Anita Dwi Rahmawati, Siswanto Siswanto, Supriyadi Wibowo   +2 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

An Inverse Spectral Problem for the Matrix Sturm-Liouville Operator with a Bessel-Type Singularity

International Journal of Differential Equations, 2015
The inverse problem by the Weyl matrix is studied for the matrix Sturm-Liouville equation on a finite interval with a Bessel-type singularity in the end of the interval.
Natalia Bondarenko
doaj   +1 more source

Incidence matrix and cover matrix of nested interval orders

The Electronic Journal of Linear Algebra, 2012
For any poset P , its incidence matrix n and its cover matrix C are the P × P (0, 1) matrices such that n(x, y) = 1 if any only if x is less than y in P and C(x, y) = 1 if any only if x is covered by y in P. It is shown that n and C are conjugate to each other in the incidence algebra of P over a field of characteristic 0 provided P is the nested ...
Yaokun Wu, Shizhen Zhao
openaire   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Interval State Estimation of Electricity-Gas Systems Considering Measurement Correlations

Energies
The popularization of electricity-gas systems leads to increasing demand for state management of systems. However, the existence of neglected measurement correlations brings uncertainties to the electricity-gas systems state estimation. In this paper, an
Yan Huang, Lin Feng
doaj   +1 more source

Interval-valued Fuzzy Matrices with Interval-valued Fuzzy Rows and Columns

Fuzzy Information and Engineering, 2015
Fuzzy matrix (FM) is a very important topic of fuzzy algebra. In FM, the elements belong to the unit interval [0,1]. When the elements of FM are the subintervals of the unit interval [0,1], then the FM is known as interval-valued fuzzy matrix (IVFM).
Madhumangal Pal
doaj   +1 more source