Results 91 to 100 of about 90,995 (334)

Kaempferol Alleviates Acrolein‐Induced Lung Injury In Vitro and In Vivo by Binding to Peli2 and Disrupting the Peli2‐NLRP3 Interaction

Food Frontiers, EarlyView.
Abstract Acrolein (ACR) is a highly toxic agent that induces lung inflammation and causes acute lung injury (ALI). However, effective treatments for ACR‐induced ALI are currently lacking. We investigated the protective effects of kaempferol (Kae) against ACR‐induced ALI using in vitro (HBE and BEAS‐2B cells) and in vivo murine models (male C57BL/6 mice)
Juanjuan Ma, Zhao Yin, Jie Zheng, Xingyou Mo, Shaoji Li, Hua Liu, Shiyi Ou   +6 more
wiley   +1 more source

A novel rat model of lumbar disc herniation induced by puncture: accurate positioning and controllable degree of herniation

Journal of Orthopaedic Surgery and Research
Background Lumbar disc herniation (LDH) is the serious stage of intervertebral disc degeneration (IDD), and the location and degree of intervertebral disc herniation are closely related to clinical symptoms and signs.
Ming Yang, Jiangling Zhou, Qiandong Yang, Bo Yu, Juan Cai, Tianyong Hou   +5 more
doaj   +1 more source

TWEAK and TSLP in disc degeneration and spontaneous hernia resorption

JOR Spine, 2020
Spontaneous degeneration of an intervertebral disc is caused by inflammation that accompanies exposure of the avascular nucleus pulposus to circulation, triggering an autoimmune inflammatory reaction.
Tetsuro Ohba, Hirotaka Haro
doaj   +1 more source

Occurrence and Regional Distribution of TRAIL and DR5 on Temporomandibular Joint Discs: Comparison of Disc Derangement with and without Reduction [PDF]

, 2010
Background Tumor necrosis factor (TNF)–related apoptosis-inducing ligand (TRAIL) is an apoptosis-inducing member of the TNF gene family which triggers apoptotic signals by interaction with its receptors.
Almeida, Luis Eduardo, Leonardi, Rosalia, Loreto, Carla, Trevilatto, Paula C.   +3 more
core   +1 more source

A Phase 1 Study of the Pharmacokinetics, Safety, and Tolerability of Posdinemab (JNJ‐63733657) in Healthy Chinese Adults

The Journal of Clinical Pharmacology, EarlyView.
Abstract Posdinemab, a humanized immunoglobulin G1/κ monoclonal antibody, binds with high affinity to phosphorylated tau protein which is associated with Alzheimer's disease (AD) pathophysiology. Posdinemab reduced tau seeding in murine models and was well tolerated in Phase‐1 clinical studies.
Fangfang Wang, Juanfang Liu, Daisy Bai, Lingjue Li, Maggie Fedgchin, David Henley, Haiyan Li, Fan Zhang   +7 more
wiley   +1 more source

A LONG-TERM OUTCOMES OF LUMBAR DISK ARTHROPLASTY AND LUMBAR INTERBODY FUSION IN SURGICAL TREATMENT OF LUMBAR INTERVERTEBRAL DISK DEGENERATIVE DISEASE: A SYSTEMATIC REVIEW

Байкальский медицинский журнал
Relevance. Patients with long-standing discogenic low back pain who do not show clinical improvement after conservative treatment are referred for surgical treatments such as lumbar fusion or total disc arthroplasty.The purpose –– to evaluate the long ...
Ivan A. Stepanov, Vladimir A Beloborodov
doaj   +1 more source

Lubricin Immunohistochemical Expression in Human Temporomandibular Joint Disc with Internal Derangement [PDF]

, 2011
Lubricin is a chondroprotective, mucinous glycoprotein which contribute to joint lubrication, especially to boundary lubrication and maintains joint integrity.
Almeida, Luis Eduardo, Leonardi, Rosalia, Loreto, Carla   +2 more
core   +2 more sources

Characterizing Microstructural and Mechanical Properties of Dancer Achilles Tendon Using Ultrashort Echo Time MRI and Shear Wave Elastography Ultrasound

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Previous observations of multi‐echo ultrashort echo time (UTE) magnetic resonance imaging (MRI) decay data from the Achilles tendon (AT) report an off‐resonance non‐water signal associated with non‐collagenous extracellular matrix (ECM) constituents.
Anna M. Horner, Felix M. Gonzalez, Courtney N. Gleason, Amanda Blackmon, Emma Faulkner, Damian Dyckman, Monica B. Umpierrez, Philip K.‐W. Wong, Vahid Khalilzad Sharghi, Pan Su, David A. Reiter   +10 more
wiley   +1 more source

A comparison of interferential current efficacy in elderly intervertebral disc degeneration patients with or without sarcopenia: a retrospective study

BMC Musculoskeletal Disorders
Background Intervertebral disc degeneration and sarcopenia are both age-related diseases without effective treatments. Their comorbidities may worsen the prognosis, and further studies on interaction and therapy are needed.
Hui Yuan, Lini Dong, Ou Zhang, Xiaoxiao Wang, Zejun Chen, Yunchao Li, Haoyu He, Guohua Lü, Jing Li, Lei Kuang   +9 more
doaj   +1 more source

Therapeutic Window of Laser Dosimetry for the Treatment of Knee Osteoarthritis

Lasers in Surgery and Medicine, EarlyView.
ABSTRACT Objectives We propose a non‐destructive laser method that uses controlled thermomechanical action to treat degenerative cartilage changes. The technique aims to reduce pain, offers a minimally invasive option for early‐ to mid‐stage degeneration, and lessens the need for joint replacement.
Yulia Alexandrovskaya, Felix Feldchtein, Andreas Glatz, Anatoly Shekhter, Elizaveta Kon, Valerii Vinokur, Emil Sobol   +6 more
wiley   +1 more source