Results 111 to 120 of about 31,985 (192)

Macrophage Changes and High‐Throughput Sequencing in Aging Mouse Intervertebral Disks

JOR SPINE, Volume 8, Issue 2, June 2025.
We aimed to evaluate caudal IVD specimens from adult and older mice to study M0, M1, and M2 macrophage polarization and their aging‐related secretory phenotypes. Additionally, we aimed to assess macrophage polarization in aged disks, along with the differential expression of genes related to aging, and the hub genes involved in aging.
Wei Wang, Cheng Jiang, Jiong‐Hui Chen, Yong‐Long Chen, Zhen‐Wu Zhang, Zhi‐Chao Yang, Jun Li, Xiao‐Chuan Li   +7 more
wiley   +1 more source

Biomimetic Microchannel Integrated Silk Fibroin Scaffold for Regeneration of Intervertebral Disc Degeneration. [PDF]

Biomater Res
Zhang T, Cheng Z, Zhang Z, Du L, Li Z, Jiang Z, Zheng Z, Kong D, Zhu M, Li W, Xu B.   +10 more
europepmc   +1 more source

Phosphatidylcholine Ameliorates Palmitic Acid‐Induced Lipotoxicity by Facilitating Endoplasmic Reticulum and Mitochondria Contacts in Intervertebral Disc Degeneration

JOR SPINE, Volume 8, Issue 2, June 2025.
The abnormal lipotoxic condition in nucleus pulposus (NP) cells from advanced‐stage intervertebral disc degeneration (IDD) was identified through untargeted LC/MS metabolomics and magnetic resonance spectroscopy. The palmitic acid accumulation resulted in endoplasmic reticulum stress, mitochondrial damage, lipid droplet accumulation, and senescence of ...
Shuangshuang Tu, Yijun Dong, Chuanfu Li, Mingxin Jiang, Liqun Duan, Wenzhi Zhang, Xi Chen   +6 more
wiley   +1 more source

CCL3 correlates with ferroptosis in intervertebral disc degeneration and its prognostic significance. [PDF]

Sci Rep
Chen H, Xu P, Mao L, Wang Y, Feng Z, Wang Z, Shen C, Xu Y.   +7 more
europepmc   +1 more source

Evidence for a Causal Association Between Human Cytomegalovirus Infection and Chronic Back Pain: A One‐Sample Mendelian Randomization Study

JOR SPINE, Volume 8, Issue 2, June 2025.
ABSTRACT Background Chronic back pain (CBP) is a major cause of disability globally. While its etiology is multifactorial, specific contributing genetic and environmental factors remain to be discovered. Paraspinal muscle fat has been shown in human and preclinical studies to be related to CBP. One potential risk factor is infection by cytomegalovirus (
Maryam Kazemi Naeini, Maxim B. Freidin, Isabelle Granville Smith, Stephen Ward, Frances M. K. Williams   +4 more
wiley   +1 more source

Role of neurogenic inflammation in intervertebral disc degeneration. [PDF]

World J Orthop
Peng BG, Li YC, Yang L.
europepmc   +1 more source

Molecular Subtypes and Immune Microenvironment Characterization of the Annulus Fibrosus in Intervertebral Disc Degeneration: Insights From Translation Factor‐Related Gene Analysis

JOR SPINE, Volume 8, Issue 2, June 2025.
TFGs are valuable for distinguishing between different IVDD clusters. The predictive model developed demonstrates strong performance in forecasting IVDD. A thorough analysis of these clusters can contribute to a deeper understanding of the molecular mechanisms of IVDD.
Sikuan Zheng, Xiaokun Zhao, Hui Wu, Xuhui Cuan, Xigao Cheng, Dingwen He   +5 more
wiley   +1 more source

Nucleus pulposus cell network modelling in the intervertebral disc. [PDF]

NPJ Syst Biol Appl
Tseranidou S, Segarra-Queralt M, Chemorion FK, Le Maitre CL, Piñero J, Noailly J.   +5 more
europepmc   +1 more source

Identification and Validation of Circadian Rhythm‐Related Genes Involved in Intervertebral Disc Degeneration and Analysis of Immune Cell Infiltration via Machine Learning

JOR SPINE, Volume 8, Issue 2, June 2025.
Within this manuscript, bioinformatics and experimental methods are used to explore the role of circadian rhythm and immunity in Intervertebral Disc Degeneration (IVDD). CCND1, FOXO1, FRMD8, NTRK2, PRRT1, and TFPI were successfully demonstrated to be hub rhythm‐related genes in the process of IVDD together with immunity.
Yongbo Zhang, Liuyang Chen, Sheng Yang, Rui Dai, Hua Sun, Liang Zhang   +5 more
wiley   +1 more source

Exploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degeneration. [PDF]

J Orthop Surg Res
Chen H, Tang T, Xue C, Liu X, Xi Z, Xie L, Kang R.   +6 more
europepmc   +1 more source