Results 31 to 40 of about 92,764 (319)

Exosomes and exosomal miRNAs: A new therapy for intervertebral disc degeneration

Frontiers in Pharmacology, 2022
Low back pain has been found as a major cause of global disease burden and disability. Intervertebral disc degeneration is recognized as the vital factor causing low back pain.
Zhichao Li, Yan Wu, Guoqing Tan, Zhanwang Xu, Haipeng Xue, Haipeng Xue   +5 more
doaj   +1 more source

A novel magnetic resonance imaging postprocessing technique for the assessment of intervertebral disc degeneration-Correlation with histological grading in a rabbit disc degeneration model. [PDF]

, 2019
Introduction:Estimation of intervertebral disc degeneration on magnetic resonance imaging (MRI) is challenging. Qualitative schemes used in clinical practice correlate poorly with pain and quantitative techniques have not entered widespread clinical use.
Chamoli, Uphar, Diwan, Ashish D, Kato, Kenji, Masuda, Koichi, Miyazaki, Shingo, Sheldrick, Kyle   +5 more
core   +1 more source

Current strategies for treatment of intervertebral disc degeneration: substitution and regeneration possibilities [PDF]

, 2017
Background: Intervertebral disc degeneration has an annual worldwide socioeconomic impact masked as low back pain of over 70 billion euros. This disease has a high prevalence over the working age class, which raises the socioeconomic impact over the ...
A Joshi, A LA Binch, a S Htay, A Schmocker, A Thorvaldsson, AA Marino, AA Thorpe, AT Reza, AT Reza, ATH Choy, ATH Choy, B Gantenbein-Ritter, B Xu, B Xu, BH Wang, BI Woods, BJC Freeman, BP Chan, C Zhu, C-Q Zhao, CC Guterl, CC Guterl, CL Le Maitre, D Denning, D Puppi, D Purmessur, D Périé, DDN Sun, DF Coutinho, DJ Aguiar, DR Pereira, E Alsberg, EA Growney Kalaf, EH Cassinelli, ES Place, F Wang, G Chang, G Crevensten, G Feng, G Khang, G Pattappa, G Vadalà, GR Buttermann, H Cheng, H Tao, H-J Wilke, HA Lin, J Berger, J Naresh-Babu, J Silva-Correia, J Silva-Correia, J Silva-Correia, J Silva-Correia, J Silva-Correia, J Zhu, JC Iatridis, JD Thomas, JF DeLucca, JF Mano, JL Bron, JM Lee, JP Jarman, JP Thompson, JPG Urban, JS Temenoff, JT Martin, JT Martin, JT Oliveira, JT Oliveira, JWS Hayami, K Rezwan, K Takahashi, K-W Kim, KD Hudson, KL Spiller, L Calderon, L Jiang, L Koepsell, L Saad, L Xin, LA Nasto, LJ Suggs, LM Benneker, LM Boyd, M Endres, M Likhitpanichkul, M Sato, M Yasen, MB Coventry, MC Cornejo, MS Gupta, MS Gupta, N Bangel-Ruland, N Wismer, P Heneghan, P Roughley, P Schexnailder, P-PA Vergroesen, PB Malafaya, PY Neo, Q Guo, R Chou, RD Abbott, RD Bowles, RG Long, S Roberts, S Roberts, S van Uden, S Varghese, S-H Park, SBG Blanquer, SCW Chan, SK Leckie, SM Mueller, SM Richardson, SM Richardson, SR Van Tomme, T Oner, T Pirvu, TK Chik, V Stroganov, WC Bae, X Tang, X Zhou, Y Tao, Y Wu, Y-C Huang, Z Fang, Z Karimi, Z Sun   +129 more
core   +1 more source

Application of single and cooperative different delivery systems for the treatment of intervertebral disc degeneration

Frontiers in Bioengineering and Biotechnology, 2022
Intervertebral disc (IVD) degeneration (IDD) is the most universal pathogenesis of low back pain (LBP), a prevalent and costly medical problem across the world.
Zongtai Liu, Changfeng Fu
doaj   +1 more source

Effects of Changes in Osmolarity on the Biological Activity of Human Normal Nucleus Pulposus Mesenchymal Stem Cells

Stem Cells International, 2022
The expansion and maintenance of the NPMSC (nucleus pulposus mesenchymal stem cell) phenotype are considered as potential therapeutic tools for clinical applications in intervertebral disc tissue engineering and regenerative medicine.
Hua Zhang, Wei Li, YaoHong Wu, Shengquan Zhang, Jie Li, Letian Han, Haoyu Chen, Ziyu Wang, Cailiang Shen, Yinshun Zhang, Hui Tao   +10 more
doaj   +1 more source

Patterning the Void: Combining L‐Systems with Archimedean Tessellations as a Perspective for Tissue Engineering Scaffolds

Advanced Functional Materials, EarlyView.
This study introduces a novel multi‐scale scaffold design using L‐fractals arranged in Archimedean tessellations for tissue regeneration. Despite similar porosity, tiles display vastly different tensile responses (1–100 MPa) and deformation modes. In vitro experiments with hMSCs show geometry‐dependent growth and activity. Over 55 000 tile combinations
Maria Kalogeropoulou, Kenny A. van Kampen, Pierpaolo Fucile, Carlos Mota, Lorenzo Moroni   +4 more
wiley   +1 more source

Role of macrophage in intervertebral disc degeneration

Bone Research
Intervertebral disc degeneration is a degenerative disease where inflammation and immune responses play significant roles. Macrophages, as key immune cells, critically regulate inflammation through polarization into different phenotypes. In recent years,
Yiming Dou, Yiming Zhang, Yang Liu, Xun Sun, Xinyu Liu, Bin Li, Qiang Yang   +6 more
doaj   +1 more source

Development of a deep learning model for automatic detection of narrowed intervertebral disc space sites in caudal thoracic and lumbar lateral X-ray images of dogs

Frontiers in Veterinary Science
Intervertebral disc disease is the most common spinal cord-related disease in dogs, caused by disc material protrusion or extrusion that compresses the spinal cord, leading to clinical symptoms.
Junseol Park, Junseol Park, Hyunwoo Cho, Yewon Ji, Kichang Lee, Hakyoung Yoon, Hakyoung Yoon   +6 more
doaj   +1 more source

Association of magnetic resonance assessed disc degeneration and late clinical recurrence in dogs treated surgically for thoracolumbar intervertebral disc extrusions

Journal of Veterinary Internal Medicine, 2021
Background Radiographic signs of intervertebral disc mineralization are thought to indicate sites of future recurrence of disc extrusion (Hansen type I) but the relationship between evidence of disc degeneration on magnetic resonance imaging (MRI) and ...
Sara Longo, Sergio A. Gomes, Chiara Briola, Katherine Duffy, Mike Targett, Nick D. Jeffery, Paul Freeman   +6 more
doaj   +1 more source

The Comparison between Herniated and Non-Herniated Disc Levels Regarding Intervertebral Disc Space Height and Disc Degeneration, A Magnetic Resonance Study

Diagnostics, 2023
Purpose: The main purpose of this study was to evaluate the intervertebral disc height and intervertebral disc degeneration between the normal group and the group with disc herniation at the level of the L4–L5 intervertebral disc by MRI using the ...
Türkhun Çetin, Sevket Kahraman, Volkan Kızılgöz, Sonay Aydın   +3 more
doaj   +1 more source