Results 31 to 40 of about 31,985 (192)

An overview of the postcranial osteology of caecilians (Gymnophiona, Lissamphibia)

The Anatomical Record, EarlyView.
Abstract Caecilians comprise a relatively small (~220 species) group (Gymnophiona) of snake‐like or worm‐like, mostly tropical amphibians. Most adult caecilians are fossorial, although some species may live in aquatic or semi‐aquatic environments, either as larvae or adults.
Rodolfo Otávio Santos, Mark Wilkinson, Hussam Zaher   +2 more
wiley   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu   +12 more
wiley   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Development of multiparametric bioprinting method for generation of 3D printed cell‐laden structures

Biotechnology Progress, EarlyView.
Abstract The organ transplantation field requires new approaches for replacing and regenerating tissues due to the lack of adequate transplant methods. Three‐dimensional (3D) extrusion‐based bioprinting is a rapid prototyping approach that can engineer 3D scaffolds for tissue regeneration applications. In this process, 3D printed cell‐based constructs,
Sophie Lipshutz, Yoontae Kim, Micaila Curtis, Leanne Friedrich, Stella Alimperti   +4 more
wiley   +1 more source

Pharmacokinetics, Safety, and Tolerability of Single‐Dose Dazukibart in Healthy Adults in China and Japan: Results From 2 Randomized, Double‐Blind, Phase 1 Studies

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Dazukibart is a humanized monoclonal antibody selectively targeting interferon‐β. The pharmacokinetics (PK), safety, tolerability, and immunogenicity of dazukibart were evaluated in 2 double‐blind, randomized, placebo‐controlled, single‐dose, Phase 1 studies in healthy adults in China (Study 1: N = 18; dazukibart 900 mg = 15; placebo = 3) and ...
Naihan Chen, Yamato Sano, Xiaohong Wang, Shuiyi Hu, Junichi Tabira, Xin Luo, Hiroki Yoshimatsu, John Prybylski, Myron Chu, Haiyan Li, Kenji Takazawa   +10 more
wiley   +1 more source

Impact of through‐slice gradient optimization for dynamic slice‐wise shimming in the cervico‐thoracic spinal cord

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose This study investigates the effectiveness of through‐slice gradient optimization in dynamic slice‐wise B0 shimming of the cervico‐thoracic spinal cord to enhance signal recovery in gradient‐echo (GRE) EPI sequences commonly used in functional MRI studies. Methods Six volunteers underwent MRI acquisitions with dynamic shim updating (DSU)
Arnaud Breheret, Alexandre D'Astous, Yixin Ma, Jason P. Stockmann, Julien Cohen‐Adad   +4 more
wiley   +1 more source

Multi‐center benchmarking of cervical spinal cord RF coils for 7 T MRI: A traveling spines study

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose The depth within the body, small diameter, long length, and varying tissue surrounding the spinal cord impose specific considerations when designing RF coils. The optimal coil configuration for 7 T cervical spinal cord MRI is unknown and currently there are very few coil options.
Eva Alonso‐Ortiz, Daniel Papp, Robert L. Barry, Kyota Poëti, Alan C. Seifert, Kyle M. Gilbert, Nibardo Lopez‐Rios, Jan Paska, Falk Eippert, Nikolaus Weiskopf, Laura Beghini, Nadine N. Graedel, Robert Trampel, Martina F. Callaghan, Christoph S. Aigner, Patrick Freund, Maryam Seif, Aurélien Destruel, Virginie Callot, Johanna Vannesjo, Julien Cohen‐Adad   +20 more
wiley   +1 more source

Imaging of intervertebral disc prostheses

Diagnostic and Interventional Imaging, 2012
Disc arthroplasty is the replacement of a painful pathological intervertebral disc by a prosthesis, which, unlike spinal fixation, has the advantage of retaining vertebral mobility in the segment concerned. The success of the procedure is dictated by the indication.
Nicolas Amoretti, V. Lesbats, M.E. Fonquerne, N. Bronsard, E. Hovorka, P.-Y. Marcy, A. Iannessi, Olivier Hauger   +7 more
openaire   +3 more sources

Chronic sequelae and owner burdens are common following canine intervertebral disc disease

Veterinary Record, EarlyView.
Abstract Background Canine intervertebral disc disease (IVDD) is common and may be managed conservatively or surgically. However, little is known about long‐term sequelae, quality of life and owners’ emotional burden after diagnosis. Methods Information regarding signalment, neuroanatomical lesion localisation, diagnostic imaging results and treatment ...
Frederik Samsøe‐Schmidt, Mette Berendt, James Edward Miles   +2 more
wiley   +1 more source

Diurnal Asymmetric Loading Modulates Cell Phenotype in Intervertebral Disc. [PDF]

JOR Spine
Dynamic loading followed by continuous static loading negatively modulates the phenotype of IVD cells in an organ culture model. Comparable to the free swelling treatment after dynamic loading, physical treatment to reduce the stress on the IVD, even temporarily, may help to prevent the acceleration of deformity and degeneration.
Zhang Y, Xu J, Zhou Z, Richards RG, Alini M, Grad S, Li Z.   +6 more
europepmc   +2 more sources