Results 11 to 20 of about 82,752 (303)

Macrophages and Intervertebral Disc Degeneration

International Journal of Molecular Sciences, 2023
The intervertebral disc (IVD) aids in motion and acts to absorb energy transmitted to the spine. With little inherent regenerative capacity, degeneration of the intervertebral disc results in intervertebral disc disease, which contributes to low back ...
Jinsha Koroth, Erick O. Buko, R. Abbott, C. Johnson, B. Ogle, L. Stone, A. Ellingson, E. Bradley   +7 more
semanticscholar   +1 more source

SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis

Experimental and Molecular Medicine, 2023
Investigation of a mitochondrial protein linked with intervertebral disc degeneration (IDD) provides possible therapeutic targets for lower back pain. Intervertebral discs act as shock absorbers in the spine, and excessive load over time can cause disc ...
Jianxin Mao, Di Wang, Dong Wang, Qi Wu, Qiliang Shang, Chu Gao, Huanbo Wang, Han Wang, Mu Du, Pandi Peng, Haoruo Jia, Xiaolong Xu, Jie Wang, Liu Yang, Zhuojing Luo   +14 more
semanticscholar   +1 more source

Aging, cell senescence, the pathogenesis and targeted therapies of intervertebral disc degeneration

Frontiers in Pharmacology, 2023
Intervertebral disc degeneration (IVDD) refers to the aging and degenerative diseases of intervertebral disc components such as nucleus pulposus, annulus fibrosus, and cartilage endplate, and is the main cause of chronic low back pain.
Jiongnan Xu, Tingji Shao, J. Lou, Jun Zhang, Chen Xia   +4 more
semanticscholar   +1 more source

The role of ferroptosis in intervertebral disc degeneration

Frontiers in Cell and Developmental Biology, 2023
Nucleus pulposus, annulus fibrosus, and cartilage endplate constitute an avascular intervertebral disc (IVD), which is crucial for spinal and intervertebral joint mobility.
Chunyang Fan, Genglei Chu, Zilin Yu, Zhongwei Ji, Fanchen Kong, Lingye Yao, Jiale Wang, D. Geng, Xiexing Wu, Haiqing Mao   +9 more
semanticscholar   +1 more source

Protective role of the alpha-1-antitrypsin in intervertebral disc degeneration

Journal of Orthopaedic Surgery and Research, 2021
Background Intervertebral disc degeneration is a complex disease with high prevalence. It suggests that cell death, senescence, and extracellular matrix degradation are involved in the pathogenesis. Alpha-1 antitrypsin (AAT), a serine protease inhibitor,
Weikun Liu, Yanfu Wang
doaj   +1 more source

Application study of 3D LAVA-Flex on lumbar intervertebral disc degeneration

European Journal of Medical Research, 2021
Background Degeneration of the intervertebral discs are very common diseases, indicating the specific or malignant changes in intervertebral disc component, structure and function.
Tiefang Liu, Yonghao Wang, Zhengyang Xu, Tao Wu, Xiao Zang, Meng Li, Jinfeng Li   +6 more
doaj   +1 more source

Discogenic Low Back Pain: Anatomy, Pathophysiology and Treatments of Intervertebral Disc Degeneration

International Journal of Molecular Sciences, 2022
Intervertebral disc (IVD) degeneration is a major contributing factor for discogenic low back pain (LBP), causing a significant global disability. The IVD consists of an inner core proteoglycan-rich nucleus pulposus (NP) and outer lamellae collagen-rich ...
I. L. Mohd Isa, S. Teoh, N. H. Mohd Nor, S. Mokhtar   +3 more
semanticscholar   +1 more source

Treatment of Intervertebral Disc Degeneration

Orthopaedic Surgery, 2022
Intervertebral disc degeneration (IDD) causes a variety of signs and symptoms, such as low back pain (LBP), intervertebral disc herniation, and spinal stenosis, which contribute to high social and economic costs.
Jingguo Xin, Yongjie Wang, Zhiying Zheng, Shuo Wang, Shibo Na, Shaokun Zhang   +5 more
semanticscholar   +1 more source

Clinical and magnetic resonance imaging characteristics of thoracolumbar intervertenral disk extrusions and protrusions in large breed dogs [PDF]

, 2016
It has recently been shown that the fat-derived hormone adiponectin has the ability to decrease hyperglycemia and to reverse insulin resistance. However, bacterially produced full-length adiponectin is functionally inactive. Here, we show that endogenous
Beltran, E, De Decker, S, Gomes, S A, Kenny, P J, Packer, R M A, Volk, H A   +5 more
core   +4 more sources

Identification of Key Modules and Hub Genes of Annulus Fibrosus in Intervertebral Disc Degeneration

Frontiers in Genetics, 2021
Background: Intervertebral disc degeneration impairs the quality of patients lives. Even though there has been development of many therapeutic strategies, most of them remain unsatisfactory due to the limited understanding of the mechanisms that underlie
Hantao Wang, Hantao Wang, Wenhui Liu, Bo Yu, Xiaosheng Yu, Bin Chen   +5 more
doaj   +1 more source