Results 11 to 20 of about 84,616 (318)
Macrophages and Intervertebral Disc Degeneration
International Journal of Molecular Sciences, 2023 The intervertebral disc (IVD) aids in motion and acts to absorb energy transmitted to the spine. With little inherent regenerative capacity, degeneration of the intervertebral disc results in intervertebral disc disease, which contributes to low back ...
Jinsha Koroth +7 more
semanticscholar +3 more sources
Treatment of Intervertebral Disc Degeneration
Orthopaedic Surgery, 2022 Intervertebral disc degeneration (IDD) causes a variety of signs and symptoms, such as low back pain (LBP), intervertebral disc herniation, and spinal stenosis, which contribute to high social and economic costs.
Jingguo Xin +5 more
semanticscholar +4 more sources
The role of ferroptosis in intervertebral disc degeneration
Frontiers in Cell and Developmental Biology, 2023 Nucleus pulposus, annulus fibrosus, and cartilage endplate constitute an avascular intervertebral disc (IVD), which is crucial for spinal and intervertebral joint mobility.
Chunyang Fan +9 more
semanticscholar +4 more sources
Pathomechanism of intervertebral disc degeneration
JOR SPINE, 2020 Intervertebral disc degeneration (IDD) is the main contributor to low back pain, which is a leading cause of disability worldwide. Although substantial progress has been made in elucidating the molecular mechanisms of IDD, fundamental and long‐lasting ...
Takeshi Oichi +4 more
semanticscholar +4 more sources
The Proteolysis of ECM in Intervertebral Disc Degeneration [PDF]
International Journal of Molecular Sciences, 2022 Intervertebral disc (IVD) degeneration (IDD) is a pathological process that commonly occurs throughout the human life span and is a major cause of lower back pain. Better elucidation of the molecular mechanisms involved in disc degeneration could provide
Huaizhen Liang +5 more
semanticscholar +3 more sources
Role of macrophage in intervertebral disc degeneration
Bone ResearchIntervertebral disc degeneration is a degenerative disease where inflammation and immune responses play significant roles. Macrophages, as key immune cells, critically regulate inflammation through polarization into different phenotypes. In recent years,
Yiming Dou +6 more
doaj +3 more sources
Genetic Therapy for Intervertebral Disc Degeneration [PDF]
International Journal of Molecular Sciences, 2021 Intervertebral disc (IVD) degeneration can cause chronic lower back pain (LBP), leading to disability. Despite significant advances in the treatment of discogenic LBP, the limitations of current treatments have sparked interest in biological approaches ...
Eun Ji Roh +7 more
semanticscholar +3 more sources
Molecular Mechanisms of Intervertebral Disc Degeneration
Spine Surgery and Related Research, 2019 Intervertebral disc degeneration is a well-known cause of disability, the result of which includes neck and back pain with associated mobility limitations.
Sean Rider, Shuichi Mizuno, James Kang
doaj +4 more sources
Cell Proliferation, 2023 Low back pain (LBP) is a leading cause of labour loss and disability worldwide, and it also imposes a severe economic burden on patients and society. Among symptomatic LBP, approximately 40% is caused by intervertebral disc degeneration (IDD). IDD is the
Yidian Wang +5 more
semanticscholar +1 more source
Intervertebral disc degeneration—Current therapeutic options and challenges
Frontiers in Public Health, 2023 Degeneration of the intervertebral disc (IVD) is a normal part of aging. Due to the spine's declining function and the development of pain, it may affect one's physical health, mental health, and socioeconomic status.
Ankit Samanta, T. Lufkin, P. Kraus
semanticscholar +1 more source