Role of macrophage in intervertebral disc degeneration [PDF]
Bone ResearchIntervertebral disc degeneration is a degenerative disease where inflammation and immune responses play significant roles. Macrophages, as key immune cells, critically regulate inflammation through polarization into different phenotypes. In recent years,
Yiming Dou +6 more
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Exploring extracellular vesicles as novel therapeutic agents for intervertebral disc degeneration: delivery, applications, and mechanisms [PDF]
Stem Cell Research & TherapyIntervertebral disc degeneration is a multifactorial degenerative disease that poses a significant threat to the health of the elderly population. Current treatments primarily focus on physical therapy, medication, and surgery to alleviate symptoms ...
Yuxin Jin +15 more
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Innovating intervertebral disc degeneration therapy: Harnessing the power of extracellular vesicles [PDF]
Journal of Orthopaedic TranslationIntervertebral disc degeneration is the leading cause of low back pain, imposing significant burdens on patients, societies, and economies. Advancements in regenerative medicine have spotlighted extracellular vesicles as promising nanoparticles for ...
Shanfeng Chen +5 more
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Phosphatidylcholine Ameliorates Palmitic Acid‐Induced Lipotoxicity by Facilitating Endoplasmic Reticulum and Mitochondria Contacts in Intervertebral Disc Degeneration [PDF]
JOR SPINE, Volume 8, Issue 2, June 2025.The abnormal lipotoxic condition in nucleus pulposus (NP) cells from advanced‐stage intervertebral disc degeneration (IDD) was identified through untargeted LC/MS metabolomics and magnetic resonance spectroscopy. The palmitic acid accumulation resulted in endoplasmic reticulum stress, mitochondrial damage, lipid droplet accumulation, and senescence of ...
Shuangshuang Tu +6 more
wiley +2 more sources
Inhibitory activity of CXCR4 attenuates intervertebral disc degeneration by regulating TXNIP/NLRP3 expression [PDF]
, 2022 Purpose: To explore the inhibitory effect and mechanism of action of CXCR4 on intervertebral disc degeneration.Methods: The expression of CXCR4 was assessed in different degrees of degenerate disc tissues. Nucleus pulposus (NP) cells-induced degeneration
Tao, Xiaohui, Yu, Jie
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Macrophages and Intervertebral Disc Degeneration
International Journal of Molecular Sciences, 2023 The intervertebral disc (IVD) aids in motion and acts to absorb energy transmitted to the spine. With little inherent regenerative capacity, degeneration of the intervertebral disc results in intervertebral disc disease, which contributes to low back pain and significant disability in many individuals. Increasing evidence suggests that IVD degeneration
Jinsha Koroth +7 more
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Pathomechanism of intervertebral disc degeneration
JOR SPINE, 2020 AbstractIntervertebral disc degeneration (IDD) is the main contributor to low back pain, which is a leading cause of disability worldwide. Although substantial progress has been made in elucidating the molecular mechanisms of IDD, fundamental and long‐lasting treatments for IDD are still lacking.
Sakae Tanaka +5 more
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Identification of Key Modules and Hub Genes of Annulus Fibrosus in Intervertebral Disc Degeneration
Frontiers in Genetics, 2021 Background: Intervertebral disc degeneration impairs the quality of patients lives. Even though there has been development of many therapeutic strategies, most of them remain unsatisfactory due to the limited understanding of the mechanisms that underlie
Hantao Wang +5 more
doaj +1 more source
陆军军医大学学报, 2023 Objective To explore the role and possible mechanism of lysyl oxidase (LOX) in age-related degeneration of intervertebral disc. Methods Six SD rats, aged of 2, 8 and 20 months respectively, were subjected, and then underwent intervertebral disc MRI and X-
LI Jianmin +3 more
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Exosomes and exosomal miRNAs: A new therapy for intervertebral disc degeneration
Frontiers in Pharmacology, 2022 Low back pain has been found as a major cause of global disease burden and disability. Intervertebral disc degeneration is recognized as the vital factor causing low back pain.
Zhichao Li +5 more
doaj +1 more source