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Intervertebral Disc Degeneration
2017The human spine consists of 23 intervertebral discs adjoining the vertebral bodies. These discs provide mechanical support and spinal motion and function to distribute loads from daily activities. Tissues of intervertebral discs share similarities to those of diarthrodial joints, such as a thin layer of cartilage that lines the interface between the ...
Wilson C.W. Chan +3 more
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Modern concepts of intervertebral disc degeneration
Voprosy neirokhirurgii imeni N.N. Burdenko, 2020The widespread prevalence of degenerative spine diseases and achievements in the treatment of these lesions have not yet led to an answer the main question: «What is the etiology of spine degeneration?» Treatment will remain symptomatic if primary cause of disease will be unclear. However, improvement of genetic and molecular survey gradually clarifies
A O Gushcha, A R Yusupova
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Pathogenesis of Intervertebral Disc Degeneration
2013It is estimated that as much as 84 % of the population will suffer from low back pain (LBP) at some point in their lifetime (Walker 2000), with around 10 % of sufferers being chronically disabled. As such LBP is one of the most prevalent musculoskeletal conditions affecting Western society (Stewart et al.
Hoyland, JA +2 more
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Role of autophagy in intervertebral disc degeneration
Journal of Cellular Physiology, 2021AbstractIntervertebral disc degeneration (IDD) is a leading contributor to low back pain. The intervertebral disc (IVD) is composed of three tissue types: the central gelatinous nucleus pulposus (NP) tissue, the surrounding annulus fibrosus (AF) tissue, and the inferior and superior cartilage endplates.
Rebecca Kritschil +3 more
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Myxomatous degeneration of the lumbar intervertebral disc
Neurosurgery, 1985Abstract Sixteen patients were operated on for lumbar pain and pain radiating into the sciatic nerve distribution. In all 16, when the anulus fibrosus was incised, soft, gray disc material extruded under pressure like toothpaste being squeezed from a tube.
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The role of estrogen in intervertebral disc degeneration
Steroids, 2020Intervertebral disc degeneration (IVDD) is a main contributor to low back and radicular pain, which imposes heavy economic burdens on society. However, the etiology and mechanism of IVDD are complex and still not completely clear. In particular, the role of estrogen in IVDD has not received much attention in recent research, although estrogen plays a ...
Xin-Feng Li, Xiao-Xing Song, Lin-Yu Jin
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MMPs and ADAMTSs in intervertebral disc degeneration
Clinica Chimica Acta, 2015Intervertebral disc degeneration (IDD) is the most common diagnosis in patients with low back pain, a leading cause of musculoskeletal disability worldwide. The major components of extracellular matrix (ECM) within the discs are type II collagen (Col II) and aggrecan.
Xiao-Hua Yu +7 more
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The molecular basis of intervertebral disc degeneration [PDF]
The Spine Journal, 2013 Intervertebral disc (IVD) degeneration remains a clinically important condition for which treatment is costly and relatively ineffective. The molecular basis of degenerative disc disease has been an intense focus of research recently, which has greatly increased our understanding of the biology underlying this process.To review the current ...
David Greg Anderson +4 more
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Genetic aspects of intervertebral disc degeneration
Reviews in the Neurosciences, 2015Abstract Intervertebral disc degeneration (IVDD) is one of the common causes of low back pain. Similar to many other multifactorial diseases, it is affected by environmental and genetic factors. Although not completely understood, genetic factors include a wide spectrum of variations, such as single nucleotide polymorphisms, which could ...
Sina Abdollahzade +4 more
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Biochemical changes in intervertebral disc degeneration
Biochimica et Biophysica Acta (BBA) - General Subjects, 1981The distribution of the principal matrix components, collagen, proteoglycans and water, across the diameter of human normal and degenerate intervertebral discs was compared. Little difference in collagen distribution was noted between normal and degenerate tissue but water and proteoglycan content decreased with degeneration, particularly in the centre
S.M. Eisenstein +2 more
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