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Intervertebral disc degeneration
European Spine Journal, 1993Disc degeneration in the human spine is a complex phenomenon characterised by biochemical change in the nucleus pulposus and inner annulus and the formation of clefts and fissures radiating from the central area of the disc towards the periphery. In addition, and probably independent of these phenomena, discrete defects in the outer annular attachement
R D, Fraser +2 more
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Smoking and intervertebral disc degeneration
Medical Hypotheses, 2001Cigarette smokers have an increased risk of low back pain which may be caused by disc degeneration and spinal instability, for example. Ischemia, apoptosis, faulty synthesis of disc macromolecules, and an imbalance between disc matrix proteinases and their inhibitors may be involved in the pathogenesis of disc degeneration. Along with degeneration, the
R R, Fogelholm, A V, Alho
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Modern concepts of intervertebral disc degeneration
Voprosy neirokhirurgii imeni N.N. Burdenko, 2020The widespread prevalence of degenerative spine diseases and achievements in the treatment of these lesions have not yet led to an answer the main question: «What is the etiology of spine degeneration?» Treatment will remain symptomatic if primary cause of disease will be unclear. However, improvement of genetic and molecular survey gradually clarifies
A O, Gushcha, A R, Yusupova
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Imaging Intervertebral Disc Degeneration
Journal of Bone and Joint Surgery, 2006Magnetic resonance imaging provides excellent anatomic detail of spinal tissues, but fails to provide the type of information that permits a definitive diagnosis in many patients with back pain. New imaging strategies that can be applied to the study of intervertebral disc degeneration include diffusion-weighted imaging, magnetic resonance imaging ...
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Genetic aspects of intervertebral disc degeneration
Reviews in the Neurosciences, 2015Abstract Intervertebral disc degeneration (IVDD) is one of the common causes of low back pain. Similar to many other multifactorial diseases, it is affected by environmental and genetic factors. Although not completely understood, genetic factors include a wide spectrum of variations, such as single nucleotide polymorphisms, which could ...
Sara, Hanaei +4 more
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Biochemical changes in intervertebral disc degeneration
Biochimica et Biophysica Acta (BBA) - General Subjects, 1981The distribution of the principal matrix components, collagen, proteoglycans and water, across the diameter of human normal and degenerate intervertebral discs was compared. Little difference in collagen distribution was noted between normal and degenerate tissue but water and proteoglycan content decreased with degeneration, particularly in the centre
G, Lyons, S M, Eisenstein, M B, Sweet
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Molecular basis of intervertebral disc degeneration
The Spine Journal, 2004This review will acquaint the reader with normal development, structure, and function of the intervertebral disc. The disc is composed of the vertebral endplate, nucleus pulposus, and annulus fibrosus. These three functional components all serve important purposes for health and function of the disc. Nutrition and biomechanics are also discussed.
Matthew H, Walker, D Greg, Anderson
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Pathogenesis of Intervertebral Disc Degeneration
2013It is estimated that as much as 84 % of the population will suffer from low back pain (LBP) at some point in their lifetime (Walker 2000), with around 10 % of sufferers being chronically disabled. As such LBP is one of the most prevalent musculoskeletal conditions affecting Western society (Stewart et al.
Hoyland, JA +2 more
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Mechanical Initiation of Intervertebral Disc Degeneration
Spine, 2000Mechanical testing of cadaveric lumbar motion segments.To test the hypothesis that minor damage to a vertebral body can lead to progressive disruption of the adjacent intervertebral disc.Disc degeneration involves gross structural disruption as well as cell-mediated changes in matrix composition, but there is little evidence concerning which comes ...
M A, Adams +4 more
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Genetics of the Degenerated Intervertebral Disc
World Neurosurgery, 2012Given the genetic and proteomic advances of the past decade, understanding of the molecular etiopathogenesis of several complex diseases is increasing. Intervertebral disc disease (IVDD) is no different from other complex diseases where both environmental and genetic constituents are considered causes.
Samuel, Kalb +4 more
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