Results 221 to 230 of about 39,314 (264)

Fundamentals of Intervertebral Disc Degeneration

World Neurosurgery, 2022
Lumbar disc degeneration is one of the leading causes of chronic low back pain. The degenerative cascade is often initiated by an imbalance between catabolic and anabolic processes in the intervertebral discs. As a consequence of extracellular matrix degradation, neoinnervation and neovascularization take place.
Sertac Kirnaz, Charisse Capadona, Taylor Wong, Jacob L. Goldberg, Branden Medary, Fabian Sommer, Lynn B. McGrath, Roger Härtl   +7 more
openaire   +2 more sources

Intervertebral disc degeneration in the dog. Part 1: Anatomy and physiology of the intervertebral disc and characteristics of intervertebral disc degeneration

Veterinary Journal, 2013
Intervertebral disc (IVD) degeneration is common in dogs and can give rise to a number of diseases, such as IVD herniation, cervical spondylomyelopathy, and degenerative lumbosacral stenosis. Although there have been many reports and reviews on the clinical aspects of canine IVD disease, few reports have discussed and reviewed the process of IVD ...
Lucas A Smolders, Guy C M Grinwis, Ragnvi Hagman   +2 more
exaly   +3 more sources

Intervertebral disc degeneration

Nature Reviews Disease Primers
Intervertebral disc (IVD) degeneration is a naturally occurring process that is a consequence of biological ageing and exposure to normal physiological loading over a lifetime and is characterized by loss of IVD tissue structural integrity. The nucleus pulposus changes with loss of pressurization, decreased collagen concentration and loss of ...
Bradley T. Hammoor, Christopher S. Lai, Grace X. Xiong, Dawn M. Elliott, Brian Snyder, Edward Vresilovic, Christopher M. Bono, Benjamin R. Freedman   +7 more
  +6 more sources

Intervertebral disc degeneration

European Spine Journal, 1993
Disc degeneration in the human spine is a complex phenomenon characterised by biochemical change in the nucleus pulposus and inner annulus and the formation of clefts and fissures radiating from the central area of the disc towards the periphery. In addition, and probably independent of these phenomena, discrete defects in the outer annular attachement
R D, Fraser, O L, Osti, B, Vernon-Roberts   +2 more
openaire   +2 more sources

Smoking and intervertebral disc degeneration

Medical Hypotheses, 2001
Cigarette smokers have an increased risk of low back pain which may be caused by disc degeneration and spinal instability, for example. Ischemia, apoptosis, faulty synthesis of disc macromolecules, and an imbalance between disc matrix proteinases and their inhibitors may be involved in the pathogenesis of disc degeneration. Along with degeneration, the
R R, Fogelholm, A V, Alho
openaire   +2 more sources

Epigenetic regulation in intervertebral disc degeneration

Trends in Molecular Medicine, 2022
Intervertebral disc (IVD) degeneration is the leading cause of low back pain, which has a striking impact on numerous patients. Therefore, comprehensively illuminating the regulatory mechanisms of IVD degeneration is of great significance. Here, we discuss the latest advances in understanding the main epigenetic mechanisms regulating IVD degeneration.
Gaocai Li, Weifeng Zhang, Huaizhen Liang, Cao Yang   +3 more
openaire   +2 more sources

Genetics of the Degenerated Intervertebral Disc

World Neurosurgery, 2012
Given the genetic and proteomic advances of the past decade, understanding of the molecular etiopathogenesis of several complex diseases is increasing. Intervertebral disc disease (IVDD) is no different from other complex diseases where both environmental and genetic constituents are considered causes.
Samuel, Kalb, Nikolay L, Martirosyan, M Yashar S, Kalani, Guy G, Broc, Nicholas, Theodore   +4 more
openaire   +2 more sources

Mechanobiology of the Intervertebral Disc and Relevance to Disc Degeneration

Journal of Bone and Joint Surgery, 2006
Mechanical loading of the intervertebral disc may contribute to disc degeneration by initiating degeneration or by regulating cell-mediated remodeling events that occur in response to the mechanical stimuli of daily activity. This article is a review of the current knowledge of the role of mechanical stimuli in regulating intervertebral disc cellular ...
Lori A, Setton, Jun, Chen
openaire   +2 more sources

Imaging Intervertebral Disc Degeneration

Journal of Bone and Joint Surgery, 2006
Magnetic resonance imaging provides excellent anatomic detail of spinal tissues, but fails to provide the type of information that permits a definitive diagnosis in many patients with back pain. New imaging strategies that can be applied to the study of intervertebral disc degeneration include diffusion-weighted imaging, magnetic resonance imaging ...
openaire   +2 more sources

Modern concepts of intervertebral disc degeneration

Voprosy neirokhirurgii imeni N.N. Burdenko, 2020
The widespread prevalence of degenerative spine diseases and achievements in the treatment of these lesions have not yet led to an answer the main question: «What is the etiology of spine degeneration?» Treatment will remain symptomatic if primary cause of disease will be unclear. However, improvement of genetic and molecular survey gradually clarifies
A O, Gushcha, A R, Yusupova
openaire   +2 more sources