Results 231 to 240 of about 39,314 (264)

Pathogenesis of Intervertebral Disc Degeneration

2013
It is estimated that as much as 84 % of the population will suffer from low back pain (LBP) at some point in their lifetime (Walker 2000), with around 10 % of sufferers being chronically disabled. As such LBP is one of the most prevalent musculoskeletal conditions affecting Western society (Stewart et al.
Hoyland, JA, Richardson, Stephen; id_orcid 0000-0002-7637-4135, Freemont, AJ   +2 more
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The molecular basis of intervertebral disc degeneration

The Spine Journal, 2013
Intervertebral disc (IVD) degeneration remains a clinically important condition for which treatment is costly and relatively ineffective. The molecular basis of degenerative disc disease has been an intense focus of research recently, which has greatly increased our understanding of the biology underlying this process.To review the current ...
Christopher K, Kepler, Ravi K, Ponnappan, Chadi A, Tannoury, Marakand V, Risbud, David G, Anderson   +4 more
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Myxomatous degeneration of the lumbar intervertebral disc

Neurosurgery, 1985
Abstract Sixteen patients were operated on for lumbar pain and pain radiating into the sciatic nerve distribution. In all 16, when the anulus fibrosus was incised, soft, gray disc material extruded under pressure like toothpaste being squeezed from a tube.
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Mechanobiology in intervertebral disc degeneration and regeneration

The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2005
The intervertebral disc is an avascular, pliant, composite structure that separates spinal vertebrae and, in health, serves to support compression and facilitate movement. Its morphological organization is directed by fluid pressure and consists of a central swelling gel (nucleus), surrounded peripherally by a constraining ligament (annulus fibrosus ...
J C, Lotz, A, Staples, A, Walsh, A H, Hsieh   +3 more
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The role of estrogen in intervertebral disc degeneration

Steroids, 2020
Intervertebral disc degeneration (IVDD) is a main contributor to low back and radicular pain, which imposes heavy economic burdens on society. However, the etiology and mechanism of IVDD are complex and still not completely clear. In particular, the role of estrogen in IVDD has not received much attention in recent research, although estrogen plays a ...
Lin-Yu, Jin, Xiao-Xing, Song, Xin-Feng, Li   +2 more
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Mechanical Initiation of Intervertebral Disc Degeneration

Spine, 2000
Mechanical testing of cadaveric lumbar motion segments.To test the hypothesis that minor damage to a vertebral body can lead to progressive disruption of the adjacent intervertebral disc.Disc degeneration involves gross structural disruption as well as cell-mediated changes in matrix composition, but there is little evidence concerning which comes ...
M A, Adams, B J, Freeman, H P, Morrison, I W, Nelson, P, Dolan   +4 more
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MMPs and ADAMTSs in intervertebral disc degeneration

Clinica Chimica Acta, 2015
Intervertebral disc degeneration (IDD) is the most common diagnosis in patients with low back pain, a leading cause of musculoskeletal disability worldwide. The major components of extracellular matrix (ECM) within the discs are type II collagen (Col II) and aggrecan.
Wen-Jun, Wang, Xiao-Hua, Yu, Cheng, Wang, Wei, Yang, Wen-Si, He, Shu-Jun, Zhang, Yi-Guo, Yan, Jian, Zhang   +7 more
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Genetic aspects of intervertebral disc degeneration

Reviews in the Neurosciences, 2015
Abstract Intervertebral disc degeneration (IVDD) is one of the common causes of low back pain. Similar to many other multifactorial diseases, it is affected by environmental and genetic factors. Although not completely understood, genetic factors include a wide spectrum of variations, such as single nucleotide polymorphisms, which could ...
Sara, Hanaei, Sina, Abdollahzade, Alireza, Khoshnevisan, Christopher K, Kepler, Nima, Rezaei   +4 more
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Biochemical changes in intervertebral disc degeneration

Biochimica et Biophysica Acta (BBA) - General Subjects, 1981
The distribution of the principal matrix components, collagen, proteoglycans and water, across the diameter of human normal and degenerate intervertebral discs was compared. Little difference in collagen distribution was noted between normal and degenerate tissue but water and proteoglycan content decreased with degeneration, particularly in the centre
G, Lyons, S M, Eisenstein, M B, Sweet
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Molecular Basis of Intervertebral Disc Degeneration

2012
Intervertebral disc (IVD) degeneration is a disease of the discs connecting adjoining vertebrae in which structural damage leads to degeneration of the disc and surrounding area. Degeneration of the disc is considered to be a normal process of aging, but can accelerate faster than expected or be precipitated by other factors.
Dipika, Gopal, Allen L, Ho, Amol, Shah, John H, Chi   +3 more
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