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Aging and Degeneration in the Lumbar Intervertebral Disc
Orthopedic Clinics of North America, 19771. The maintenance of the nucleus pulposus matrix in the adult human disc is dependent on the functional integrity of the cartilage end plate cells. 2. Cartilage end plate senescence is followed by compensatory cartilaginous metaplasia of annulus fibrosus cells. 3.
Kenneth P.H. Pritzker +1 more
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Molecular basis of intervertebral disc degeneration
The Spine Journal, 2004This review will acquaint the reader with normal development, structure, and function of the intervertebral disc. The disc is composed of the vertebral endplate, nucleus pulposus, and annulus fibrosus. These three functional components all serve important purposes for health and function of the disc. Nutrition and biomechanics are also discussed.
Matthew H. Walker, D. Greg Anderson
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Molecular Basis of Intervertebral Disc Degeneration
2012Intervertebral disc (IVD) degeneration is a disease of the discs connecting adjoining vertebrae in which structural damage leads to degeneration of the disc and surrounding area. Degeneration of the disc is considered to be a normal process of aging, but can accelerate faster than expected or be precipitated by other factors.
Amol Shah +3 more
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Mechanobiology in intervertebral disc degeneration and regeneration
The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2005The intervertebral disc is an avascular, pliant, composite structure that separates spinal vertebrae and, in health, serves to support compression and facilitate movement. Its morphological organization is directed by fluid pressure and consists of a central swelling gel (nucleus), surrounded peripherally by a constraining ligament (annulus fibrosus ...
Adam H. Hsieh +3 more
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Mechanical Initiation of Intervertebral Disc Degeneration
Spine, 2000Mechanical testing of cadaveric lumbar motion segments.To test the hypothesis that minor damage to a vertebral body can lead to progressive disruption of the adjacent intervertebral disc.Disc degeneration involves gross structural disruption as well as cell-mediated changes in matrix composition, but there is little evidence concerning which comes ...
Helen P. Morrison +4 more
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Aging and Degeneration of the Human Intervertebral Disc
Spine, 1995Human intervertebral discs undergo age-related degenerative changes that contribute to some of the most common causes of impairment and disability for middle aged and older persons: spine stiffness, neck pain, and back pain. Potential causes of the age-related degeneration of intervertebral discs include declining nutrition, loss of viable cells, cell ...
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The Biology of Intervertebral Disc Degeneration
2010Intervertebral discs act as the joints of the spinal column and provide it with mobility and flexibility. The predominant mechanical functions of intervertebral discs are to transmit the compressive loads through the spine and to allow it to bend and twist.
Cornelia Neidlinger-Wilke +1 more
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Nanobacteria and intervertebral disc degeneration
Medical Hypotheses, 2005Hossein Eskandary +2 more
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A new immunometabolic perspective of intervertebral disc degeneration
Nature Reviews Rheumatology, 2021Vera Francisco +2 more
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