Results 21 to 30 of about 84,616 (318)

SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis

Experimental and Molecular Medicine, 2023
Investigation of a mitochondrial protein linked with intervertebral disc degeneration (IDD) provides possible therapeutic targets for lower back pain. Intervertebral discs act as shock absorbers in the spine, and excessive load over time can cause disc ...
Jianxin Mao, Di Wang, Dong Wang, Qi Wu, Qiliang Shang, Chu Gao, Huanbo Wang, Han Wang, Mu Du, Pandi Peng, Haoruo Jia, Xiaolong Xu, Jie Wang, Liu Yang, Zhuojing Luo   +14 more
semanticscholar   +1 more source

Protective role of the alpha-1-antitrypsin in intervertebral disc degeneration

Journal of Orthopaedic Surgery and Research, 2021
Background Intervertebral disc degeneration is a complex disease with high prevalence. It suggests that cell death, senescence, and extracellular matrix degradation are involved in the pathogenesis. Alpha-1 antitrypsin (AAT), a serine protease inhibitor,
Weikun Liu, Yanfu Wang
doaj   +1 more source

Aging, cell senescence, the pathogenesis and targeted therapies of intervertebral disc degeneration

Frontiers in Pharmacology, 2023
Intervertebral disc degeneration (IVDD) refers to the aging and degenerative diseases of intervertebral disc components such as nucleus pulposus, annulus fibrosus, and cartilage endplate, and is the main cause of chronic low back pain.
Jiongnan Xu, Tingji Shao, J. Lou, Jun Zhang, Chen Xia   +4 more
semanticscholar   +1 more source

Application study of 3D LAVA-Flex on lumbar intervertebral disc degeneration

European Journal of Medical Research, 2021
Background Degeneration of the intervertebral discs are very common diseases, indicating the specific or malignant changes in intervertebral disc component, structure and function.
Tiefang Liu, Yonghao Wang, Zhengyang Xu, Tao Wu, Xiao Zang, Meng Li, Jinfeng Li   +6 more
doaj   +1 more source

Diabetes and intervertebral disc degeneration: A Mendelian randomization study

Frontiers in Endocrinology, 2023
Introduction Intervertebral disc degeneration (IVDD) is an important contributor of low back pain, which represents one of the most disabling symptoms within the adult population.
Pei-hao Jin, Y. Xing, Bin Xiao, Yi Wei, Kai-Zhong Yan, Jing-wei Zhao, W. Tian   +6 more
semanticscholar   +1 more source

Clinical and magnetic resonance imaging characteristics of thoracolumbar intervertenral disk extrusions and protrusions in large breed dogs [PDF]

, 2016
It has recently been shown that the fat-derived hormone adiponectin has the ability to decrease hyperglycemia and to reverse insulin resistance. However, bacterially produced full-length adiponectin is functionally inactive. Here, we show that endogenous
Beltran, E, De Decker, S, Gomes, S A, Kenny, P J, Packer, R M A, Volk, H A   +5 more
core   +4 more sources

Identification of Key Modules and Hub Genes of Annulus Fibrosus in Intervertebral Disc Degeneration

Frontiers in Genetics, 2021
Background: Intervertebral disc degeneration impairs the quality of patients lives. Even though there has been development of many therapeutic strategies, most of them remain unsatisfactory due to the limited understanding of the mechanisms that underlie
Hantao Wang, Hantao Wang, Wenhui Liu, Bo Yu, Xiaosheng Yu, Bin Chen   +5 more
doaj   +1 more source

Inhibition of lysyl oxidase accelerates intervertebral disc degeneration induced by apoptosis of nucleus pulposus cells

陆军军医大学学报, 2023
Objective To explore the role and possible mechanism of lysyl oxidase (LOX) in age-related degeneration of intervertebral disc. Methods Six SD rats, aged of 2, 8 and 20 months respectively, were subjected, and then underwent intervertebral disc MRI and X-
LI Jianmin, XING Hui, CHONG Fanli, ZHAO Runzhi   +3 more
doaj   +1 more source

Progress of melatonin in the treatment of intervertebral disc degeneration. [PDF]

Front Physiol
Yin J, Wan L, Zhang K, Yang J, Liu M, Zhao M, Li J.   +6 more
europepmc   +3 more sources

Discogenic Low Back Pain: Anatomy, Pathophysiology and Treatments of Intervertebral Disc Degeneration

International Journal of Molecular Sciences, 2022
Intervertebral disc (IVD) degeneration is a major contributing factor for discogenic low back pain (LBP), causing a significant global disability. The IVD consists of an inner core proteoglycan-rich nucleus pulposus (NP) and outer lamellae collagen-rich ...
I. L. Mohd Isa, S. Teoh, N. H. Mohd Nor, S. Mokhtar   +3 more
semanticscholar   +1 more source