Results 21 to 30 of about 123,966 (370)

In Vivo Measurements Reveal Increased Nucleus Pulposus Lactate and Oxygen Concentrations in a Goat Model of Intervertebral Disc Degeneration. [PDF]

JOR Spine
Although precise pathophysiological mechanisms remain elusive, perturbations in nutrition that adversely impact the cellular microenvironment of the central nucleus pulposus (NP) are considered key contributors to disc degeneration. In this study, we adapted brain tissue oxygen probes and microdialysis catheters for in situ determination of NP tissue ...
Rajagopal K, Schaer TP, Meadows KD, Boyes M, Hilliard R, O'Donnell JC, Dodge GR, Petrov D, Elliott DM, Mauck RL, Smith LJ, Malhotra NR.   +11 more
europepmc   +2 more sources

Phosphatidylcholine Ameliorates Palmitic Acid-Induced Lipotoxicity by Facilitating Endoplasmic Reticulum and Mitochondria Contacts in Intervertebral Disc Degeneration. [PDF]

JOR Spine
The abnormal lipotoxic condition in nucleus pulposus (NP) cells from advanced‐stage intervertebral disc degeneration (IDD) was identified through untargeted LC/MS metabolomics and magnetic resonance spectroscopy. The palmitic acid accumulation resulted in endoplasmic reticulum stress, mitochondrial damage, lipid droplet accumulation, and senescence of ...
Tu S, Dong Y, Li C, Jiang M, Duan L, Zhang W, Chen X.   +6 more
europepmc   +2 more sources

Causal Relationship Between Gut Microbiota, Blood Metabolites, and Intervertebral Disc Degeneration: A Two-Step, Two-Sample Bidirectional Mendelian Randomization Study. [PDF]

JOR Spine
We have identified several specific gut microbiota that may have an effect on intervertebral disc degeneration, and have found possible blood metabolites that mediate the effects of the gut microbiota on intervertebral disc degeneration. This study provides new insights into the mechanisms by which gut microbes are involved in the development of ...
Zheng YP, Yang DL, Wang LY, Zhu XZ, Li XC, Miao JH, Xu YS.   +6 more
europepmc   +2 more sources

Oxidative stress in intervertebral disc degeneration: Molecular mechanisms, pathogenesis and treatment

Cell Proliferation, 2023
Low back pain (LBP) is a leading cause of labour loss and disability worldwide, and it also imposes a severe economic burden on patients and society. Among symptomatic LBP, approximately 40% is caused by intervertebral disc degeneration (IDD). IDD is the
Yidian Wang, Huiguang Cheng, Tao Wang, Kun Zhang, Yumin Zhang, Xin Kang   +5 more
semanticscholar   +1 more source

Experimental intervertebral disc degeneration models [PDF]

, 2023
Intervertebral disc degeneration is a major health problem of close concern to both young and old. The problem is also growing as the global population ages.
İkinci̇ Keleş, Ayşe, Sönmez, Osman Fikret   +1 more
core   +1 more source

Intervertebral disc degeneration—Current therapeutic options and challenges

Frontiers in Public Health, 2023
Degeneration of the intervertebral disc (IVD) is a normal part of aging. Due to the spine's declining function and the development of pain, it may affect one's physical health, mental health, and socioeconomic status.
Ankit Samanta, T. Lufkin, P. Kraus
semanticscholar   +1 more source

Aging, cell senescence, the pathogenesis and targeted therapies of intervertebral disc degeneration

Frontiers in Pharmacology, 2023
Intervertebral disc degeneration (IVDD) refers to the aging and degenerative diseases of intervertebral disc components such as nucleus pulposus, annulus fibrosus, and cartilage endplate, and is the main cause of chronic low back pain.
Jiongnan Xu, Tingji Shao, J. Lou, Jun Zhang, Chen Xia   +4 more
semanticscholar   +1 more source

Protective role of the alpha-1-antitrypsin in intervertebral disc degeneration

Journal of Orthopaedic Surgery and Research, 2021
Background Intervertebral disc degeneration is a complex disease with high prevalence. It suggests that cell death, senescence, and extracellular matrix degradation are involved in the pathogenesis. Alpha-1 antitrypsin (AAT), a serine protease inhibitor,
Weikun Liu, Yanfu Wang
doaj   +1 more source

Application study of 3D LAVA-Flex on lumbar intervertebral disc degeneration

European Journal of Medical Research, 2021
Background Degeneration of the intervertebral discs are very common diseases, indicating the specific or malignant changes in intervertebral disc component, structure and function.
Tiefang Liu, Yonghao Wang, Zhengyang Xu, Tao Wu, Xiao Zang, Meng Li, Jinfeng Li   +6 more
doaj   +1 more source

Discogenic Low Back Pain: Anatomy, Pathophysiology and Treatments of Intervertebral Disc Degeneration

International Journal of Molecular Sciences, 2022
Intervertebral disc (IVD) degeneration is a major contributing factor for discogenic low back pain (LBP), causing a significant global disability. The IVD consists of an inner core proteoglycan-rich nucleus pulposus (NP) and outer lamellae collagen-rich ...
Isma Liza Mohd Isa, S. Teoh, N. H. Mohd Nor, S. Mokhtar   +3 more
semanticscholar   +1 more source