Results 21 to 30 of about 25,892 (278)

MiR-532 downregulation of the Wnt/β-catenin signaling via targeting Bcl-9 and induced human intervertebral disc nucleus pulposus cells apoptosis

Journal of Pharmacological Sciences, 2018
Objective: Intervertebral disc degeneration was characterized with aberrant intervertebral disc nucleus pulposus cells apoptosis. MiR-532 was reported to be up-regulated in the patients with intervertebral disc degeneration.
Zeyu Sun, Yuekui Jian, Hongying Fu, Bo Li   +3 more
doaj   +1 more source

Allogeneic fibroblasts ameliorate intervertebral disc degeneration by reducing osteophytes in rabbits

Frontiers in Medicine
IntroductionLow back pain (LBP) was commonly induced by intervertebral disc degeneration (IVDD), which is accompanied by the loss of disc height and osteophyte generation.
Chen Chen, Yizhuo Huang, Lei Shi, Li Zhou, Shenao Zhou, Shenao Zhou, Hongjin Wan, Xiao Yang, Jie Zhao   +8 more
doaj   +1 more source

Intervertebral Disc Degeneration

, 2017
The human spine consists of 23 intervertebral discs adjoining the vertebral bodies. These discs provide mechanical support and spinal motion and function to distribute loads from daily activities. Tissues of intervertebral discs share similarities to those of diarthrodial joints, such as a thin layer of cartilage that lines the interface between the ...
Akansha M. Shah, Sarah Yoon Ji Kwon, Wilson C. W. Chan, Danny Chan   +3 more
openaire   +6 more sources

Intervertebral Disc Biology: Genetic Basis of Disc Degeneration [PDF]

Current Molecular Biology Reports, 2018
This review aims to highlight recent advances in understanding the genetic basis of intervertebral disc degeneration (IDD).It has been known for some time that IDD is highly heritable. Recent studies, and in particular the availability of agnostic techniques such as genome-wide association studies, have identified new variants in a variety of genes ...
Munir, Sabrina, Rade, Marinko, Määttä, Juhani H., Freydin, Maxim, Williams, Frances M. K.   +4 more
openaire   +3 more sources

Role of macrophage in intervertebral disc degeneration

Bone Research
Intervertebral disc degeneration is a degenerative disease where inflammation and immune responses play significant roles. Macrophages, as key immune cells, critically regulate inflammation through polarization into different phenotypes. In recent years,
Yiming Dou, Yiming Zhang, Yang Liu, Xun Sun, Xinyu Liu, Bin Li, Qiang Yang   +6 more
doaj   +1 more source

Genetic factors in intervertebral disc degeneration

Genes & Diseases, 2016
Low back pain (LBP) is a major cause of disability and imposes huge economic burdens on human society worldwide. Among many factors responsible for LBP, intervertebral disc degeneration (IDD) is the most common disorder and is a target for intervention. The etiology of IDD is complex and its mechanism is still not completely understood.
Feng, Yi, Egan, Brian, Wang, Jinxi
openaire   +2 more sources

Ultrasound‐Triggered Gelation for Restoring Biomechanical Properties of Degenerated Functional Spinal Units

Advanced Healthcare Materials, EarlyView.
This study introduces an innovative approach to treating intervertebral disc degeneration using ultrasound‐triggered in situ hydrogel formation. Proof‐of‐concept experiments using optimized biomaterial and ultrasound parameters demonstrate partial restoration of biomechanical function and successful integration into degenerated disc tissue, offering a ...
Veerle A. Brans, Anna P. Constantinou, Matthew J. Kibble, Valeria Nele, Daniel Reumann, Luca Bau, Sebastien J. P. Callens, James P. K. Armstrong, Nicolas Newell, Constantin C. Coussios, Molly M. Stevens, Michael D. Gray   +11 more
wiley   +1 more source

Inflammatory biomarkers in sera of patients with intervertebral disc degeneration

Einstein (São Paulo)
Objective: To evaluate intervertebral disc levels of inflammatory factor (interleukin 6) and proteinase activity (cathepsin B) in patients with a degenerative disease and serum levels of interleukin 6, serum cathepsin B activity and hyaluronic acid ...
Luciano Miller Reis Rodrigues, Lilian Zerbinatti de Oliveira, Mariane de Barros Ribeiro da Silva, Camila de Melo Accardo, Adriana Braz Del Giglio, Maria Aparecida da Silva Pinhal   +5 more
doaj   +1 more source

MicroRNA in intervertebral disc degeneration [PDF]

Cell Proliferation, 2015
AbstractAetiology of intervertebral disc degeneration (IDD) is complex, with genetic, developmental, biochemical and biomechanical factors contributing to the disease process. It is becoming obvious that epigenetic processes influence evolution of IDD as strongly as the genetic background.
Zheng, Li, Xin, Yu, Jianxiong, Shen, Matthew T V, Chan, William Ka Kei, Wu   +4 more
openaire   +2 more sources

Sculpting the Future of Bone: The Evolution of Absorbable Materials in Orthopedics

Advanced Materials, EarlyView.
This review summarizes the current status of polymeric, ceramic, and metallic absorbable materials in orthopedic applications, and highlights several innovative strategies designed to enhance mechanical performance, control degradation, and promote bioactivity. We also discuss the progress and translational potential of absorbable materials in treating
Zhao Wang, Zehui Lv, Xuejie Cai, Yingjie Wang, Bo Peng, Haojing Xu, Hualuo Pang, Xingdong Yang, Jiawei Xu, Yixin Bian, Bin Feng, Peng Wen, Yufeng Zheng, Xisheng Weng   +13 more
wiley   +1 more source