Results 31 to 40 of about 82,752 (303)

Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review

Cells, 2022
Intervertebral disc degeneration (IVDD) is a pathological condition that can lead to intractable back pain or secondary neurological deficits. There is no fundamental cure for this condition, and current treatments focus on alleviating symptoms ...
Takashi Ohnishi, N. Iwasaki, H. Sudo
semanticscholar   +1 more source

Evaluation of the influence of kyphosis and scoliosis on intervertebral disc extrusion in French bulldogs [PDF]

, 2018
Although thoracic vertebral malformations with kyphosis and scoliosis are often considered incidental findings on diagnostic imaging studies of screw-tailed brachycephalic breeds, they have been suggested to interfere with spinal biomechanics and ...
BA Brisson, CW Dewey, DR Westworth, E Schlensker, E Schlensker, F Wang, Gert ter Haar, GI Hristova, HG Parker, HK Chang, Holger A. Volk, IA Stokes, J Guevar, J Street, K Faller, LA Smolders, LM De Rycke, M Charalambous, MA Stone, Maria Claudia C. M. Inglez de Souza, MP Abdel, MS Mogensen, MS Mogensen, MS Yau, N Bergknut, ND Jeffery, O Epstein, P Bernstein, P Moissonnier, R Gutierrez-Quintana, RC Brink, Richard Ryan, RM Packer, Rowena M. A. Packer, S De Decker, SA Gomes, SD Decker, Steven De Decker, T Aikawa, T Aikawa   +39 more
core   +2 more sources

Intervertebral Disc Degeneration: Functional Analysis of Bite Force and Masseter and Temporal Muscles Thickness

Prague Medical Report, 2022
Intervertebral disc degeneration is a pathological condition associated with the intervertebral disc and is related to functional alterations in the human body.
Nicole Barbosa Bettiol, Simone Cecilio Hallak Regalo, Flávia Argentato Cecilio, Ligia Maria Napolitano Gonçalves, Paulo Batista de Vasconcelos, Claire Genoveze Gauch Lopes, Lilian Mendes Andrade, Isabela Hallak Regalo, Selma Siéssere, Marcelo Palinkas   +9 more
doaj   +1 more source

Prussian Blue Nanoparticles Stabilize SOD1 from Ubiquitination‐Proteasome Degradation to Rescue Intervertebral Disc Degeneration

Advancement of science, 2022
Discography often destroys the hypoxic environment in the intervertebral disc and accelerates intervertebral disc degeneration (IVDD). Therefore, it often fails to meet the requirements for application in clinical practice.
Tangjun Zhou, X. Yang, Zhiqian Chen, Yangzi Yang, Xin Wang, Xiankun Cao, Chen Chen, Chen Han, Hai-Jun Tian, A. Qin, Jingke Fu, Jie Zhao   +11 more
semanticscholar   +1 more source

Physical disruption of intervertebral disc promotes cell clustering and a degenerative phenotype [PDF]

, 2019
© 2019, The Author(s). To test the hypothesis that physical disruption of an intervertebral disc disturbs cell-matrix binding, leading to cell clustering and increased expression of matrix degrading enzymes that contribute towards degenerative disc cell ...
Adams, M.A., Claireaux, H., Dolan, T., Flower, L., Harding, I.J., Lama, P., Le Maitre, Christine   +6 more
core   +1 more source

Mitochondrial Dysfunction in Oxidative Stress‐Mediated Intervertebral Disc Degeneration

Orthopaedic Surgery, 2022
Intervertebral disc degeneration (IVDD) is the most common contributor to low back pain (LBP). Recent studies have found that oxidative stress and reactive oxygen species (ROS) play an important role in IVDD.
Dian-Kai Wang, Huo-Liang Zheng, Wenqi Zhou, Zheng-Wei Duan, Shengdan Jiang, Bo Li, Xinfeng Zheng, Lei-Sheng Jiang   +7 more
semanticscholar   +1 more source

A novel magnetic resonance imaging postprocessing technique for the assessment of intervertebral disc degeneration-Correlation with histological grading in a rabbit disc degeneration model. [PDF]

, 2019
Introduction:Estimation of intervertebral disc degeneration on magnetic resonance imaging (MRI) is challenging. Qualitative schemes used in clinical practice correlate poorly with pain and quantitative techniques have not entered widespread clinical use.
Chamoli, Uphar, Diwan, Ashish D, Kato, Kenji, Masuda, Koichi, Miyazaki, Shingo, Sheldrick, Kyle   +5 more
core   +1 more source

Intervertebral disc degeneration and how it leads to low back pain

JOR Spine, 2022
The purpose of this review was to evaluate data generated by animal models of intervertebral disc (IVD) degeneration published in the last decade and show how this has made invaluable contributions to the identification of molecular events occurring in ...
A. Diwan, J. Melrose
semanticscholar   +1 more source

Grem1 accelerates nucleus pulposus cell apoptosis and intervertebral disc degeneration by inhibiting TGF-β-mediated Smad2/3 phosphorylation

Experimental and Molecular Medicine, 2022
Intervertebral disc degeneration (IVDD) is a main cause of low back pain, and inflammatory factors play key roles in its pathogenesis. Gremlin-1 (Grem1) was reported to induce an inflammatory response in other fields.
Shunlun Chen, Linchuan Lei, Zemin Li, Fan Chen, Yuming Huang, Guowei Jiang, Xingyu Guo, Zhuoyang Zhao, Hui Liu, Hua Wang, Caijun Liu, Zhaomin Zheng, Jianru Wang   +12 more
semanticscholar   +1 more source

Computer assisted characterization of cervical intervertebral disc degeneration in MRI [PDF]

, 2009
A texture-based pattern recognition system is proposed for the automatic characterization of cervical intervertebral disc degeneration from saggital magnetic resonance images of the spine.
Boniatis, I, Cavouras, D, Costaridou, L, Michopoulou, S, Panagiotopoulos, E, Panayiotakis, G   +5 more
core   +1 more source