Results 41 to 50 of about 82,752 (303)

Application of stem cells in the repair of intervertebral disc degeneration

Stem cell research & therapeutics, 2022
Intervertebral disc degeneration (IDD) is a common disease that increases with age, and its occurrence is stressful both psychologically and financially. Stem cell therapy for IDD is emerging. For this therapy, stem cells from different sources have been
Wentao Zhang, Tianze Sun, Ying Li, Ming Yang, Yantao Zhao, Jing Liu, Zhonghai Li   +6 more
semanticscholar   +1 more source

Prevalence and breed predisposition for thoracolumbar intervertebral disc disease in cats [PDF]

, 2016
Objectives The objective was to evaluate the prevalence and possible breed predilections for thoracolumbar intervertebral disc disease (IVDD) in cats. Methods Medical records and imaging studies of cats diagnosed with thoracolumbar IVDD between January ...
De Decker, S, Volk, H A, Warner, A-S
core   +1 more source

Gut-disc axis: A cause of intervertebral disc degeneration and low back pain?

European spine journal, 2022
Low back pain (LBP), a widely prevalent and costly disease around the world, is mainly caused by intervertebral disc (IVD) degeneration (IDD). Although numerous factors may trigger this degenerative process, microbiome dysbiosis has recently been ...
Wentian Li, Kaitao Lai, N. Chopra, Zhaomin Zheng, Abhirup Das, A. Diwan   +5 more
semanticscholar   +1 more source

Single-Cell RNA-Seq Analysis of Cells from Degenerating and Non-Degenerating Intervertebral Discs from the Same Individual Reveals New Biomarkers for Intervertebral Disc Degeneration

International Journal of Molecular Sciences, 2022
In this study, we used single-cell transcriptomic analysis to identify new specific biomarkers for nucleus pulposus (NP) and inner annulus fibrosis (iAF) cells, and to define cell populations within non-degenerating (nD) and degenerating (D) human ...
Hosni Cherif, M. Mannarino, Alain S Pacis, J. Ragoussis, O. Rabau, J. Ouellet, L. Haglund   +6 more
semanticscholar   +1 more source

Effect of sIL-13Rα2-Fc on the progression of rat tail intervertebral disc degeneration

Journal of Orthopaedic Surgery and Research, 2019
Background The incidence of degenerative disc disease caused by intervertebral disc injury is increasing annually, seriously affecting the quality of life of patients and increasing the disease burden on society.
Xin Wang, Junhao Sun, Jianshi Tan, Pengzhong Fang, Jinlei Chen, Wen Yuan, Huajiang Chen, Yang Liu   +7 more
doaj   +1 more source

Current strategies for treatment of intervertebral disc degeneration: substitution and regeneration possibilities [PDF]

, 2017
Background: Intervertebral disc degeneration has an annual worldwide socioeconomic impact masked as low back pain of over 70 billion euros. This disease has a high prevalence over the working age class, which raises the socioeconomic impact over the ...
A Joshi, A LA Binch, a S Htay, A Schmocker, A Thorvaldsson, AA Marino, AA Thorpe, AT Reza, AT Reza, ATH Choy, ATH Choy, B Gantenbein-Ritter, B Xu, B Xu, BH Wang, BI Woods, BJC Freeman, BP Chan, C Zhu, C-Q Zhao, CC Guterl, CC Guterl, CL Le Maitre, D Denning, D Puppi, D Purmessur, D Périé, DDN Sun, DF Coutinho, DJ Aguiar, DR Pereira, E Alsberg, EA Growney Kalaf, EH Cassinelli, ES Place, F Wang, G Chang, G Crevensten, G Feng, G Khang, G Pattappa, G Vadalà, GR Buttermann, H Cheng, H Tao, H-J Wilke, HA Lin, J Berger, J Naresh-Babu, J Silva-Correia, J Silva-Correia, J Silva-Correia, J Silva-Correia, J Silva-Correia, J Zhu, JC Iatridis, JD Thomas, JF DeLucca, JF Mano, JL Bron, JM Lee, JP Jarman, JP Thompson, JPG Urban, JS Temenoff, JT Martin, JT Martin, JT Oliveira, JT Oliveira, JWS Hayami, K Rezwan, K Takahashi, K-W Kim, KD Hudson, KL Spiller, L Calderon, L Jiang, L Koepsell, L Saad, L Xin, LA Nasto, LJ Suggs, LM Benneker, LM Boyd, M Endres, M Likhitpanichkul, M Sato, M Yasen, MB Coventry, MC Cornejo, MS Gupta, MS Gupta, N Bangel-Ruland, N Wismer, P Heneghan, P Roughley, P Schexnailder, P-PA Vergroesen, PB Malafaya, PY Neo, Q Guo, R Chou, RD Abbott, RD Bowles, RG Long, S Roberts, S Roberts, S van Uden, S Varghese, S-H Park, SBG Blanquer, SCW Chan, SK Leckie, SM Mueller, SM Richardson, SM Richardson, SR Van Tomme, T Oner, T Pirvu, TK Chik, V Stroganov, WC Bae, X Tang, X Zhou, Y Tao, Y Wu, Y-C Huang, Z Fang, Z Karimi, Z Sun   +129 more
core   +1 more source

NF‐κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration

Cell Proliferation, 2021
Intervertebral disc degeneration (IDD) is a common clinical degenerative disease of the spine. A series of factors, such as inflammation, oxidative stress and mechanical stress, promote degradation of the extracellular matrix (ECM) of the intervertebral ...
Guangzhi Zhang, Ming-Qiang Liu, Haiwei Chen, Zuolong Wu, Yicheng Gao, Zhanjun Ma, Xuegang He, X. Kang   +7 more
semanticscholar   +1 more source

Novel therapeutic strategies for degenerative disc disease: Review of cell biology and intervertebral disc cell therapy

SAGE Open Medicine, 2018
Intervertebral disc degeneration is a disease of the discs connecting adjoining vertebrae in which structural damage leads to loss of disc integrity.
Joseph Fernandez-Moure, Caitlyn A Moore, Keemberly Kim, Azim Karim, Kevin Smith, Zonia Barbosa, Jeffrey Van Eps, Pranela Rameshwar, Bradley Weiner   +8 more
doaj   +1 more source

Targeting Ferroptosis With Ginsenoside Rg3 Alleviates Intervertebral Disc Degeneration. [PDF]

Orthop Surg
Ginsenosides Rg3 were used to repair the degenerative nucleus pulposus; Furthermore, Rg3 was identified as the bioactive molecule that inhibits the occurrence of ferroptosis through inhibiting PRKAA2 expression in degenerated discs. ABSTRACT Objective Intervertebral disc degeneration (IVDD) has been closely associated with ferroptosis in nucleus ...
Xu W, Geng F, Zhang K, Wang Y.
europepmc   +2 more sources

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc. [PDF]

, 2012
Despite the high prevalence of intervertebral disc disease, little is known about changes in intervertebral disc cells and their regenerative potential with ageing and intervertebral disc degeneration.
Alini, Mauro, Ando, Kiyoshi, Chan, Danny, Cheah, Kathryn S E, Grad, Sibylle, Kato, Shunichi, Masuda, Koichi, Mishima, Taishi, Mochida, Joji, Nakai, Tomoko, Nakamura, Yoshihiko, Okano, Hideyuki, Risbud, Makarand V, Sakai, Daisuke, Yamamura, Ken-ichi   +14 more
core   +2 more sources