Results 41 to 50 of about 84,616 (318)

Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review

Cells, 2022
Intervertebral disc degeneration (IVDD) is a pathological condition that can lead to intractable back pain or secondary neurological deficits. There is no fundamental cure for this condition, and current treatments focus on alleviating symptoms ...
Takashi Ohnishi, N. Iwasaki, H. Sudo
semanticscholar   +1 more source

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc. [PDF]

, 2012
Despite the high prevalence of intervertebral disc disease, little is known about changes in intervertebral disc cells and their regenerative potential with ageing and intervertebral disc degeneration.
Alini, Mauro, Ando, Kiyoshi, Chan, Danny, Cheah, Kathryn S E, Grad, Sibylle, Kato, Shunichi, Masuda, Koichi, Mishima, Taishi, Mochida, Joji, Nakai, Tomoko, Nakamura, Yoshihiko, Okano, Hideyuki, Risbud, Makarand V, Sakai, Daisuke, Yamamura, Ken-ichi   +14 more
core   +2 more sources

Intervertebral disc degeneration and how it leads to low back pain

JOR Spine, 2022
The purpose of this review was to evaluate data generated by animal models of intervertebral disc (IVD) degeneration published in the last decade and show how this has made invaluable contributions to the identification of molecular events occurring in ...
A. Diwan, J. Melrose
semanticscholar   +1 more source

Prussian Blue Nanoparticles Stabilize SOD1 from Ubiquitination‐Proteasome Degradation to Rescue Intervertebral Disc Degeneration

Advancement of science, 2022
Discography often destroys the hypoxic environment in the intervertebral disc and accelerates intervertebral disc degeneration (IVDD). Therefore, it often fails to meet the requirements for application in clinical practice.
Tangjun Zhou, X. Yang, Zhiqian Chen, Yangzi Yang, Xin Wang, Xiankun Cao, Chen Chen, Chen Han, Hai-Jun Tian, A. Qin, Jingke Fu, Jie Zhao   +11 more
semanticscholar   +1 more source

Current strategies for treatment of intervertebral disc degeneration: substitution and regeneration possibilities [PDF]

, 2017
Background: Intervertebral disc degeneration has an annual worldwide socioeconomic impact masked as low back pain of over 70 billion euros. This disease has a high prevalence over the working age class, which raises the socioeconomic impact over the ...
A Joshi, A LA Binch, a S Htay, A Schmocker, A Thorvaldsson, AA Marino, AA Thorpe, AT Reza, AT Reza, ATH Choy, ATH Choy, B Gantenbein-Ritter, B Xu, B Xu, BH Wang, BI Woods, BJC Freeman, BP Chan, C Zhu, C-Q Zhao, CC Guterl, CC Guterl, CL Le Maitre, D Denning, D Puppi, D Purmessur, D Périé, DDN Sun, DF Coutinho, DJ Aguiar, DR Pereira, E Alsberg, EA Growney Kalaf, EH Cassinelli, ES Place, F Wang, G Chang, G Crevensten, G Feng, G Khang, G Pattappa, G Vadalà, GR Buttermann, H Cheng, H Tao, H-J Wilke, HA Lin, J Berger, J Naresh-Babu, J Silva-Correia, J Silva-Correia, J Silva-Correia, J Silva-Correia, J Silva-Correia, J Zhu, JC Iatridis, JD Thomas, JF DeLucca, JF Mano, JL Bron, JM Lee, JP Jarman, JP Thompson, JPG Urban, JS Temenoff, JT Martin, JT Martin, JT Oliveira, JT Oliveira, JWS Hayami, K Rezwan, K Takahashi, K-W Kim, KD Hudson, KL Spiller, L Calderon, L Jiang, L Koepsell, L Saad, L Xin, LA Nasto, LJ Suggs, LM Benneker, LM Boyd, M Endres, M Likhitpanichkul, M Sato, M Yasen, MB Coventry, MC Cornejo, MS Gupta, MS Gupta, N Bangel-Ruland, N Wismer, P Heneghan, P Roughley, P Schexnailder, P-PA Vergroesen, PB Malafaya, PY Neo, Q Guo, R Chou, RD Abbott, RD Bowles, RG Long, S Roberts, S Roberts, S van Uden, S Varghese, S-H Park, SBG Blanquer, SCW Chan, SK Leckie, SM Mueller, SM Richardson, SM Richardson, SR Van Tomme, T Oner, T Pirvu, TK Chik, V Stroganov, WC Bae, X Tang, X Zhou, Y Tao, Y Wu, Y-C Huang, Z Fang, Z Karimi, Z Sun   +129 more
core   +1 more source

Computer assisted characterization of cervical intervertebral disc degeneration in MRI [PDF]

, 2009
A texture-based pattern recognition system is proposed for the automatic characterization of cervical intervertebral disc degeneration from saggital magnetic resonance images of the spine.
Boniatis, I, Cavouras, D, Costaridou, L, Michopoulou, S, Panagiotopoulos, E, Panayiotakis, G   +5 more
core   +1 more source

Physical disruption of intervertebral disc promotes cell clustering and a degenerative phenotype [PDF]

, 2019
© 2019, The Author(s). To test the hypothesis that physical disruption of an intervertebral disc disturbs cell-matrix binding, leading to cell clustering and increased expression of matrix degrading enzymes that contribute towards degenerative disc cell ...
Adams, M.A., Claireaux, H., Dolan, T., Flower, L., Harding, I.J., Lama, P., Le Maitre, Christine   +6 more
core   +1 more source

Grem1 accelerates nucleus pulposus cell apoptosis and intervertebral disc degeneration by inhibiting TGF-β-mediated Smad2/3 phosphorylation

Experimental and Molecular Medicine, 2022
Intervertebral disc degeneration (IVDD) is a main cause of low back pain, and inflammatory factors play key roles in its pathogenesis. Gremlin-1 (Grem1) was reported to induce an inflammatory response in other fields.
Shunlun Chen, Linchuan Lei, Zemin Li, Fan Chen, Yuming Huang, Guowei Jiang, Xingyu Guo, Zhuoyang Zhao, Hui Liu, Hua Wang, Caijun Liu, Zhaomin Zheng, Jianru Wang   +12 more
semanticscholar   +1 more source

Degeneration of the intervertebral disc.

Arthritis research & therapy, 2003
The intervertebral disc is a cartilaginous structure that resembles articular cartilage in its biochemistry, but morphologically it is clearly different. It shows degenerative and ageing changes earlier than does any other connective tissue in the body.
Urban, J, Roberts, S
openaire   +3 more sources

Effect of sIL-13Rα2-Fc on the progression of rat tail intervertebral disc degeneration

Journal of Orthopaedic Surgery and Research, 2019
Background The incidence of degenerative disc disease caused by intervertebral disc injury is increasing annually, seriously affecting the quality of life of patients and increasing the disease burden on society.
Xin Wang, Junhao Sun, Jianshi Tan, Pengzhong Fang, Jinlei Chen, Wen Yuan, Huajiang Chen, Yang Liu   +7 more
doaj   +1 more source