Results 41 to 50 of about 81,428 (351)

Inflammation in intervertebral disc degeneration and regeneration [PDF]

Journal of The Royal Society Interface, 2015
Intervertebral disc (IVD) degeneration is one of the major causes of low back pain, a problem with a heavy economic burden, which has been increasing in prevalence as populations age. Deeper knowledge of the complex spatial and temporal orchestration of cellular interactions and extracellular matrix remodelling is critical to improve current IVD ...
Mário A. Barbosa, Joana Caldeira, Catarina R. Almeida, Maria Molinos, Carla Cunha, Raquel Gonçalves   +5 more
openaire   +3 more sources

A novel magnetic resonance imaging postprocessing technique for the assessment of intervertebral disc degeneration-Correlation with histological grading in a rabbit disc degeneration model. [PDF]

, 2019
Introduction:Estimation of intervertebral disc degeneration on magnetic resonance imaging (MRI) is challenging. Qualitative schemes used in clinical practice correlate poorly with pain and quantitative techniques have not entered widespread clinical use.
Chamoli, Uphar, Diwan, Ashish D, Kato, Kenji, Masuda, Koichi, Miyazaki, Shingo, Sheldrick, Kyle   +5 more
core   +1 more source

The Proteolysis of ECM in Intervertebral Disc Degeneration [PDF]

International Journal of Molecular Sciences, 2022
Intervertebral disc (IVD) degeneration (IDD) is a pathological process that commonly occurs throughout the human life span and is a major cause of lower back pain. Better elucidation of the molecular mechanisms involved in disc degeneration could provide a theoretical basis for the development of lumbar disc intervention strategies.
Huaizhen Liang, Rongjin Luo, Gaocai Li, Weifeng Zhang, Yu Song, Cao Yang   +5 more
openaire   +2 more sources

Biallelic variants in the SLC13A1 sulfate transporter gene cause hyposulfatemia with a mild spondylo‐epi‐metaphyseal dysplasia

Clinical Genetics, Volume 103, Issue 1, Page 45-52, January 2023., 2023
We describe the first patient with biallelic loss‐of‐function variants in the SLC13A1 gene, encoding a renal and intestinal sulfate transporter. The consequential loss of renal sulfate reabsorption leads to hypersulfaturia and hyposulfatemia which is associated with a mild Spondylo‐Epi‐Metaphyseal skeletal Dysplasia. Abstract Sulfate is the fourth most
Jiddeke M. van de Kamp, Arend Bökenkamp, Desiree E. C. Smith, Mirjam M. C. Wamelink, Erwin E. W. Jansen, Eduard A. Struys, Quinten Waisfisz, Marieke Verkleij, Michaela F. Hartmann, Rong Wang, Stefan A. Wudy, Chiara Paganini, Antonio Rossi, Martijn J. J. Finken   +13 more
wiley   +1 more source

Novel therapeutic strategies for degenerative disc disease: Review of cell biology and intervertebral disc cell therapy

SAGE Open Medicine, 2018
Intervertebral disc degeneration is a disease of the discs connecting adjoining vertebrae in which structural damage leads to loss of disc integrity.
Joseph Fernandez-Moure, Caitlyn A Moore, Keemberly Kim, Azim Karim, Kevin Smith, Zonia Barbosa, Jeffrey Van Eps, Pranela Rameshwar, Bradley Weiner   +8 more
doaj   +1 more source

Frequency of Disc Degeneration at Different Levels of Cervical Vertebrae in Adult Patients with Neck Pain on Magnetic Resonance Imaging [PDF]

, 2020
Background:Disc degeneration is terminology used for heterogeneous changes affecting the anatomy and physiology of the intervertebral disc. Disc degeneration alters the material properties of the intervertebral disc leading to an unfavorable distribution
., Khansa, Arouj, Saba, Farooq, S. Muhammad Yousaf, Hafeez, Hasham, Haider, Jamal, Rafiq, Rana Iqra, Ramzan, Khawar, Ul Hassan, S Noor   +7 more
core   +1 more source

Intervertebral Disc Biology: Genetic Basis of Disc Degeneration [PDF]

Current Molecular Biology Reports, 2018
This review aims to highlight recent advances in understanding the genetic basis of intervertebral disc degeneration (IDD).It has been known for some time that IDD is highly heritable. Recent studies, and in particular the availability of agnostic techniques such as genome-wide association studies, have identified new variants in a variety of genes ...
Maxim B. Freidin, Juhani H Määttä, Juhani H Määttä, Sabrina Munir, Marinko Rade, Frances M K Williams   +5 more
openaire   +3 more sources

Intervertebral Disc Labeling With Learning Shape Information, A Look Once Approach [PDF]

arXiv, 2022
Accurate and automatic segmentation of intervertebral discs from medical images is a critical task for the assessment of spine-related diseases such as osteoporosis, vertebral fractures, and intervertebral disc herniation. To date, various approaches have been developed in the literature which routinely relies on detecting the discs as the primary step.
arxiv  

Metformin inhibits the apoptosis of intervertebral disc tissue cells in rabbit model with lumbar intervertebral disc degeneration [PDF]

Jichu yixue yu linchuang, 2023
Objective To investigate the impacts of metformin on autophagy and inflammation of intervertebral disc tissue in rabbits, so as to preliminarily explore the molecular mechanism of its anti-intervertebral disc degeneration.
DONG Junli, CAI Shaokang, YAN Lei, CAI Yi
doaj   +1 more source

Physical disruption of intervertebral disc promotes cell clustering and a degenerative phenotype [PDF]

, 2019
© 2019, The Author(s). To test the hypothesis that physical disruption of an intervertebral disc disturbs cell-matrix binding, leading to cell clustering and increased expression of matrix degrading enzymes that contribute towards degenerative disc cell ...
Adams, M.A., Claireaux, H., Dolan, T., Flower, L., Harding, I.J., Lama, P., Le Maitre, Christine   +6 more
core   +1 more source