Results 81 to 90 of about 83,106 (252)
HeliyonThere is still a lack of high-level evidence regarding the causal relationship between smoking and intervertebral disc degenerative diseases. This study utilized data from genome wide analysis studies and conducted two-sample Mendelian randomization ...
Zhaopu Han, Yicheng Chen, Xiaojian Ye
doaj +1 more source
Co-culture of Adult Mesenchymal Stem Cells and Nucleus Pulposus Cells in Bilaminar Pellets for Intervertebral Disc Regeneration [PDF]
, 2009 Background: Our goal is to optimize stem cell-based tissue engineering strategies in the context of the intervertebral disc environment. We explored the benefits of co-culturing nucleus pulposus cells (NPC) and adult mesenchymal stem cells (MSC) using a ...
Allon, AA, Lotz, JC, Schneider, RA
core +2 more sources
International Journal of Medical Sciences, 2021 Intervertebral disc (IVD) degeneration (IDD) is a multifactorial pathological process associated with low back pain (LBP). The pathogenesis is complicated, and the main pathological changes are IVD cell apoptosis and extracellular matrix (ECM ...
Xiao-Bo Zhang +13 more
semanticscholar +1 more source
Finite Element Analysis of Stress Distribution and Range of Motion in Discogenic Back Pain [PDF]
NeurospineObjective Precise knowledge regarding the mechanical stress applied to the intervertebral disc following each individual spine motion enables physicians and patients to understand how people with discogenic back pain should be guided in their exercises ...
Pyung-Goo Cho +3 more
doaj +1 more source
TWEAK and TSLP in disc degeneration and spontaneous hernia resorption
JOR Spine, 2020 Spontaneous degeneration of an intervertebral disc is caused by inflammation that accompanies exposure of the avascular nucleus pulposus to circulation, triggering an autoimmune inflammatory reaction.
Tetsuro Ohba, Hirotaka Haro
doaj +1 more source
STUDIES OF MOLECULAR CHANGES IN INTERVERTEBRAL DISC DEGENERATION IN ANIMAL MODEL [PDF]
Acta Ortopédica Brasileira, 2016 Objective: To evaluate the structural and molecular changes in the extracellular matrix (ECM) during the process of intervertebral disc degeneration, using animal model.
Marcelo Ferraz de Campos +5 more
doaj +2 more sources
Digoxin protects against intervertebral disc degeneration via TNF/NF-κB and LRP4 signaling
Frontiers in Immunology, 2023 BackgroundIntervertebral disc degeneration (IVDD) is a leading cause of low back pain (LBP). The pathological process of IVDD is associated with inflammatory reactions and extracellular matrix (ECM) disorders.
Qunbo Meng +14 more
doaj +1 more source
Content Analysis of General Practitioner Requested Lumbar Spine X-ray Reports [PDF]
, 2007 Aims and Background X-rays of patients with low back pain rarely show serious pathology but frequently reveal incidental age-related changes and always expose people to radiation.
Carr, Eloise C.J., Thompson, Paul W.
core +1 more source
BMC Medical Genomics, 2021 Background Degeneration of intervertebral disc is a major cause of lower back pain and neck pain. Studies have tried to unveil the regulatory network using either transcriptomic or proteomic analysis.
Chen Xu +12 more
doaj +1 more source
Structure-function relationships at the human spinal disc-vertebra interface. [PDF]
, 2018 Damage at the intervertebral disc-vertebra interface associates with back pain and disc herniation. However, the structural and biomechanical properties of the disc-vertebra interface remain underexplored.
Adams +43 more
core +1 more source