Results 81 to 90 of about 38,647 (321)

β‐Mangostin Attenuates TET2‐Mediated DNA Demethylation of Prkcg in the Prevention of Intervertebral Disc Degeneration

Advanced Science, EarlyView.
β‐Mangostin alleviates intervertebral disc degeneration through dual modulation of macrophage polarization and the TET2‐Prkcg axis in nucleus pulposus cells. Abstract Intervertebral disc degeneration (IDD) induced lower back pain is a main cause of disability, resulting in a substantial workforce loss worldwide and placing a substantial burden on the ...
Xiangzhen Kong, Hanwen Gu, Yuanqiang Zhang, Qunbo Meng, Qi Li, Kangle Song, Yanlin Li, Kaiwen Liu, Zhenchuan Liu, Rui Hu, Haoxi Zhai, Tian Li, Zemin Ling, Zhijian Wei, Fuxin Wei, Lei Cheng   +15 more
wiley   +1 more source

Occurrence and Regional Distribution of TRAIL and DR5 on Temporomandibular Joint Discs: Comparison of Disc Derangement with and without Reduction [PDF]

, 2010
Background Tumor necrosis factor (TNF)–related apoptosis-inducing ligand (TRAIL) is an apoptosis-inducing member of the TNF gene family which triggers apoptotic signals by interaction with its receptors.
Almeida, Luis Eduardo, Leonardi, Rosalia, Loreto, Carla, Trevilatto, Paula C.   +3 more
core   +1 more source

Mesenchymal stem cell therapies for intervertebral disc degeneration: consideration of the degenerate niche [PDF]

, 2019
We have previously reported a synthetic Laponite® crosslinked pNIPAM‐co‐DMAc (NPgel) hydrogel, which induces nucleus pulposus (NP) cell differentiation of human MSCs (hMSCs) without the need for additional growth factors.
Le Maitre, C.L., Sammon, C., Snuggs, J., Thorpe, A.A., Vickers, L.   +4 more
core   +1 more source

Deciphering the Acetabular Labrum's Cellular Atlas: MDK Inhibition as a Novel Therapeutic Method for Developmental Dysplasia of the Hip

Advanced Science, EarlyView.
This study explores developmental dysplasia of the hip (DDH) by analyzing acetabular labrum abnormalities using single‐cell and spatial transcriptomics. Aberrant fibrocartilage stem cell proliferation is linked to DDH progression. Targeting the MK signaling pathway with a specific inhibitor effectively alleviates early DDH abnormalities, offering ...
Runze Yang, Huiling Liu, Minghao Ge, Dingyuan Zhang, Tianhao Xu, Lei Zhang, Yanlin Zhu, Shun Li, Jian Li, Xin Ma, Weili Fu   +10 more
wiley   +1 more source

In Vivo Mouse Intervertebral Disc Degeneration Model Based on a New Histological Classification. [PDF]

PLoS ONE, 2016
Although human intervertebral disc degeneration can lead to several spinal diseases, its pathogenesis remains unclear. This study aimed to create a new histological classification applicable to an in vivo mouse intervertebral disc degeneration model ...
Takashi Ohnishi, Hideki Sudo, Koji Iwasaki, Takeru Tsujimoto, Yoichi M Ito, Norimasa Iwasaki   +5 more
doaj   +1 more source

Clinical reasoning in canine spinal disease: what combination of clinical information is useful? [PDF]

, 2015
Spinal disease in dogs is commonly encountered in veterinary practice. Numerous diseases may cause similar clinical signs and presenting histories. The study objective was to use statistical models to identify combinations of discrete parameters from the
ABRAMSON, ARMAŞU, AWANO, BAGLEY, BESALTI, BRISSON, DA COSTA, DA COSTA, DA COSTA, DE DECKER, DE RISIO, DE RISIO, DE RISIO, DELAMAIDE GASPER, DRIVER, GANDINI, HOLDER, JEFFERY, JULL, KRANENBURG, LANE, LEVINE, LU, MAY, MCKEE, MEIJ, PALUS, PARENT, PARK, RUSBRIDGE, RUSBRIDGE, SCHMIDT, TABACHNICK, TIPOLD, TIPOLD, VAN WIE, ZENG   +36 more
core   +2 more sources

FBXO2 Alleviates Intervertebral Disc Degeneration via Dual Mechanisms: Activating PINK1‐Parkin Mitophagy and Ubiquitinating LCN2 to Suppress Ferroptosis

Advanced Science, EarlyView.
F‐box only protein 2 (FBXO2) combats intervertebral disc degeneration (IVDD) by coordinating dual protection. It activates PTEN‐induced putative kinase 1 (PINK1)‐Parkin mitophagy restoring mitochondrial function and targets lipocalin‐2 (LCN2) for degradation, suppressing ferroptosis.
Tongde Wu, Yanjin Wang, Beiduo Shen, Kai Guo, Ziqi Zhu, Yongzhou Liang, Jianhua Zeng, Desheng Wu   +7 more
wiley   +1 more source

Classification of intervertebral disc degeneration by magnetic resonance [PDF]

, 2009
The authors suggest an analysis of the degeneration of intervertebral disks on human cadavers using magnetic resonance imaging. Nine lumbar spines were collected from fresh human cadavers and resonance images were captured.
Oliveira, Valdeci Manoel de [UNIFESP], Puertas, Eduardo Barros [UNIFESP], Souza, Paulo Satiro de [UNIFESP], Yamashita, Helio Kiitiro [UNIFESP]   +3 more
core   +2 more sources

WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a new mechanism by which PDIA3P1 regulates the progression of esophageal squamous cell carcinoma (ESCC). PDIA3P1 upregulates the expression of GLUT1 and HK2, promoting glycolysis and lactate production. Lactate upregulates the lactylation level of histone H4K8 and activates the transcription of target gene BMP7, ultimately ...
Tao Huang, Qi You, Jiawei Liu, Xuguang Shen, Dengjun Huang, Xinlu Tao, Zhijie He, Chengwei Wu, Xinran Xi, Shouqiang Yu, Feng Liu, Zhihao Wu, Wenjun Mao, Shaojin Zhu   +13 more
wiley   +1 more source

VEGF vascularization pathway in human intervertebral disc does not change during the disc degeneration process

BMC Research Notes, 2018
Objective During degeneration of the intervertebral disc ingrowth of blood vessels and nerves into the disc are associated with back pain. Vascular endothelial growth factors promote vasculogenesis by binding to the membrane vascular endothelial growth ...
Simona Capossela, Alessandro Bertolo, Kapila Gunasekera, Tobias Pötzel, Martin Baur, Jivko V. Stoyanov   +5 more
doaj   +1 more source