Results 81 to 90 of about 81,428 (351)

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

Clinical Effect of Minimally Invasive Microendoscopic‐Assisted Transforaminal Lumbar Interbody Fusion for Single‐Level Lumbar Disc Herniation

Orthopaedic Surgery, Volume 14, Issue 12, Page 3300-3312, December 2022., 2022
Minimally invasive surgical instruments for the MET‐Rx Microsightoscopy System (Medtronic) and a brief description of surgery procedure. Objective This retrospective study aimed to compare the clinical and radiological outcomes of transforaminal lumbar interbody fusion (TLIF) through the Wiltse approach (W‐TLIF) vs minimally invasive microendoscopy ...
Gang Chen, Long Biao Li, Zhitao Shangguan, Zhenyu Wang, Wenge Liu, Jiandong Li   +5 more
wiley   +1 more source

Spine intervertebral disc labeling using a fully convolutional redundant counting model [PDF]

arXiv, 2020
Labeling intervertebral discs is relevant as it notably enables clinicians to understand the relationship between a patient's symptoms (pain, paralysis) and the exact level of spinal cord injury. However manually labeling those discs is a tedious and user-biased task which would benefit from automated methods. While some automated methods already exist
arxiv  

TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo

Arthritis Research & Therapy, 2023
Background Intervertebral disc degeneration (IDD) is one of the most common disorders related to the spine. Inflammation, apoptosis and extracellular matrix (ECM) degradation contribute to disc degeneration in nucleus pulposus cells (NPCs).
Kun Wang, Dengbo Yao, Yuxi Li, Ming Li, Weike Zeng, Zhuangyao Liao, Engming Chen, Shixin Lu, Kaihui Su, Zhen Che, Yuwei Liang, Peng Wang, Lin Huang   +12 more
doaj   +1 more source

Digoxin protects against intervertebral disc degeneration via TNF/NF-κB and LRP4 signaling

Frontiers in Immunology, 2023
BackgroundIntervertebral disc degeneration (IVDD) is a leading cause of low back pain (LBP). The pathological process of IVDD is associated with inflammatory reactions and extracellular matrix (ECM) disorders.
Qunbo Meng, Qunbo Meng, Kaiwen Liu, Kaiwen Liu, Zhenchuan Liu, Zhenchuan Liu, Jinbo Liu, Jinbo Liu, Ziyu Tian, Ziyu Tian, Shanshan Qin, Jianlu Wei, Jianlu Wei, Lei Cheng, Lei Cheng   +14 more
doaj   +1 more source

Clarifying the nomenclature of intervertebral disc degeneration and displacement: from bench to bedside [PDF]

, 2014
As a significant determinant of low back pain, intervertebral disc degeneration (IDD) has attracted more and more attention of both investigators and physicians.
Samartzis, D, Wang, HQ
core  

Glycolysis‐Derived Lactate Induces ACSL4 Expression and Lactylation to Activate Ferroptosis during Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Glycolysis‐derived lactate activates nucleus pulposus cell ferroptosis via Histon H3K18la‐mediated ACSL4 transcription and ACSL4 lactylation and aggravate intervertebral disc degeneration. Inhibiting glycolysis via gene silencing or chemical intervention reduces the production of lactate and ameliorates ferroptosis activation and nucleus pulposus ...
Kaiqiang Sun, Yangyang Shi, Chen Yan, Shunmin Wang, Linhui Han, Fudong Li, Ximing Xu, Yuan Wang, Jingchuan Sun, Zijian Kang, Jiangang Shi   +10 more
wiley   +1 more source

Application of Oblique Lateral Interbody Fusion Combined with Bridge‐Locking Cage in Adjacent Segment Disease After Lumbar Fusion

Orthopaedic Surgery, Volume 14, Issue 12, Page 3268-3276, December 2022., 2022
Sketch map of ROI‐A fusion cage. The self‐locking double fixation inlay designed on special PEEK fusion cage (A) was directly implanted on the axis of intervertebral space (B), firmly fixed to the upper and lower vertebral bodies through the vertebral endplate, and then locked on the fusion cage (C).
Shuai Zhang, Hui Xu, Cheng‐hui Yin
wiley   +1 more source

Experimental model of intervertebral disc degeneration by needle puncture in Wistar rats

Brazilian Journal of Medical and Biological Research, 2013
Animal models of intervertebral disc degeneration play an important role in clarifying the physiopathological mechanisms and testing novel therapeutic strategies.
A.C. Issy, V. Castania, M. Castania, C.E.G. Salmon, M.H. Nogueira-Barbosa, E. Del Bel, H.L.A. Defino   +6 more
doaj   +3 more sources

Pathologic Features of the Intervertebral Disc in Young Nova Scotia Duck Tolling Retrievers Confirms Chondrodystrophy Degenerative Phenotype Associated With Genotype. [PDF]

, 2019
Chondrodystrophy results in predictable and progressive biochemical and structural changes to the intervertebral disc, resulting in early onset degeneration and dystrophic mineralization of the disc.
Bannasch, Danika, Batcher, Kevin, Dickinson, Peter, Marcellin-Little, Denis J, Murphy, Brian G, Raverty, Stephen   +5 more
core