Results 11 to 20 of about 5,630,201 (172)
Intervertebral Disc Disease in Dogs
PetsIntervertebral disc disease is the most common disease of the spine in dogs and is a main cause of pain and neurologic dysfunction. This article reviews fundamental aspects of the pathophysiology, clinical presentation, diagnosis, and treatment of disc ...
Iván Gómez Álvarez +2 more
doaj +3 more sources
Role of macrophage in intervertebral disc degeneration
Bone ResearchIntervertebral disc degeneration is a degenerative disease where inflammation and immune responses play significant roles. Macrophages, as key immune cells, critically regulate inflammation through polarization into different phenotypes. In recent years,
Yiming Dou +6 more
doaj +2 more sources
Computational simulation of the intervertebral disc [PDF]
, 2013 The intervertebral disc is a complex structure unlike any other in the human body. The capability to withstand high loads and deformations in six degrees of freedom is facilitated by the unique soft tissue structures. However, the mechanical behaviour of
Luxmoore, Bethany Jane
core +6 more sources
Stem cell horizons in intervertebral disc degeneration
Stem Cells and Cloning: Advances and Applications, 2009 Joseph Ciacci1, Allen Ho1,2, Christopher P Ames3, Rahul Jandial41Division of Neurosurgery, University of California, San Diego, La Jolla, California, USA; 2Del E Webb Neurosciences, Aging and Stem Cell Research Center, The Burnham Institute for Medical ...
Joseph Ciacci +3 more
doaj +1 more source
The biology of the ovine functional spinal unit: facet cartilage and intervertebral disc [PDF]
, 2013 Back pain will affect up to 84 % of people at some point in their lives. It is a major public health problem in Western society leading to disability and economic loss through work absence, physician visits and hospitalisation.
Gough, Caroline Shanni
core +6 more sources
Clinical Development of Regenerative Medicine Targeted for Intervertebral Disc Disease. [PDF]
Medicina (Kaunas), 2022 Low back pain is critical health, social, and economic issue in modern societies. This disease is often associated with intervertebral disc degeneration; however, contemporary treatments are unable to target this underlying pathology to alleviate the ...
Sakai D, Schol J, Watanabe M.
europepmc +2 more sources
Intervertebral disc disease in Dachshunds radiographically screened for intervertebral disc calcifications [PDF]
Acta Veterinaria Scandinavica, 2014 Intervertebral disc disease (IDD) is a very common neurological disease, Dachshunds being the breed most often affected. In this breed, IDD has a hereditary background and is associated with intervertebral disc calcification (IDC), an indicator of severe intervertebral disc degeneration.
Lappalainen, Anu K +3 more
openaire +2 more sources
Genetic Alterations in Intervertebral Disc Disease. [PDF]
Front Surg, 2016 Intervertebral disc degeneration (IVDD) is considered a multifactorial disease that is influenced by both environmental and genetic factors. The last two decades of research strongly demonstrate that genetic factors contribute about 75% of the IVDD etiology.
Martirosyan NL +7 more
europepmc +5 more sources
Protective role of the alpha-1-antitrypsin in intervertebral disc degeneration
Journal of Orthopaedic Surgery and Research, 2021 Background Intervertebral disc degeneration is a complex disease with high prevalence. It suggests that cell death, senescence, and extracellular matrix degradation are involved in the pathogenesis. Alpha-1 antitrypsin (AAT), a serine protease inhibitor,
Weikun Liu, Yanfu Wang
doaj +1 more source
Current Understanding of the Genetics of Intervertebral Disc Degeneration
Frontiers in Veterinary Science, 2020 Premature degeneration of the intervertebral disc and its association with specific chondrodystrophic dog breeds has been recognized for over a century. Several lines of evidence including disease breed predisposition, studies suggesting heritability of ...
Peter J. Dickinson, Danika L. Bannasch
doaj +1 more source