Results 21 to 30 of about 5,630,201 (172)

Exosomes and exosomal miRNAs: A new therapy for intervertebral disc degeneration

Frontiers in Pharmacology, 2022
Low back pain has been found as a major cause of global disease burden and disability. Intervertebral disc degeneration is recognized as the vital factor causing low back pain.
Zhichao Li, Yan Wu, Guoqing Tan, Zhanwang Xu, Haipeng Xue, Haipeng Xue   +5 more
doaj   +1 more source

IGF Signaling in Intervertebral Disc Health and Disease [PDF]

Frontiers in Cell and Developmental Biology, 2022
Low back pain (LBP) is a common musculoskeletal symptom, which brings a lot of pain and economic loss to patients. One of the most common causes of LBP is intervertebral disc degeneration (IVDD). However, pathogenesis is still debated, and therapeutic options are limited.
Hui Lin, Shuo Tian, Yizhong Peng, Ling Wu, Yan Xiao, Xiangcheng Qing, Zengwu Shao   +6 more
openaire   +3 more sources

A Brief Review of the Degenerative Intervertebral Disc Disease. [PDF]

Med Arch, 2019
The degenerative processes of the intervertebral disc represent an important cause of morbidity in everyday clinical practice, exerting burden on patients and clinicians treating them. Numerous factors may initiate degenerative processes, which most commonly affect the nucleus pulposus and ultimately influence the biomechanics of the whole spine.This ...
Kos N, Gradisnik L, Velnar T.
europepmc   +4 more sources

Effect of sIL-13Rα2-Fc on the progression of rat tail intervertebral disc degeneration

Journal of Orthopaedic Surgery and Research, 2019
Background The incidence of degenerative disc disease caused by intervertebral disc injury is increasing annually, seriously affecting the quality of life of patients and increasing the disease burden on society.
Xin Wang, Junhao Sun, Jianshi Tan, Pengzhong Fang, Jinlei Chen, Wen Yuan, Huajiang Chen, Yang Liu   +7 more
doaj   +1 more source

Research progress on macrophage polarization during the degeneration process of lumbar intervertebral discs [PDF]

Jichu yixue yu linchuang
During pathological progression of lumbar intervertebral disc degeneration (LIDD), macrophage polarization functions as a critical regulatory mechanism through the dynamic transition between M1 and M2 phenotypes.
CHEN Wang, LI Xugui, LI Ying
doaj   +1 more source

New Horizons of Knowledge in Intervertebral Disc Disease [PDF]

Journal of Investigative Surgery, 2020
Intervertebral disc disease (IVDD) refers to degenerative processes of the spine resulting in reduced shock-absorbing ability, which may ultimately lead to disc herniation and spinal cord compressi...
Silvia Ravalli, Giuseppe Musumeci
openaire   +4 more sources

Changes in intervertebral disc morphology persist 5 mo after 21-day bed rest [PDF]

, 2011
As part of the nutrition- countermeasures (NUC) study in Cologne, Germany in 2010, seven healthy male subjects underwent 21 days of head-down tilt bed rest and returned 153 days later to undergo a second bout of 21-day bed rest. As part of this model,
Daniel L. Belavý, Petra Frings-Meuthen, Jochen Zange, Heer, Martina, Rittweger, Jörn, Böhme, Gisela, Martina Heer, Frings-Meuthen, Petra, Gisela Böhme, Jörn Rittweger, Zange, Jochen, Bansmann, Martin, P. Martin Bansmann, Felsenberg, Dieter, Dieter Felsenberg, Belavy, Daniel Ludovic   +15 more
core   +1 more source

TWEAK and TSLP in disc degeneration and spontaneous hernia resorption

JOR Spine, 2020
Spontaneous degeneration of an intervertebral disc is caused by inflammation that accompanies exposure of the avascular nucleus pulposus to circulation, triggering an autoimmune inflammatory reaction.
Tetsuro Ohba, Hirotaka Haro
doaj   +1 more source

Development of a whole organ culture model for intervertebral disc disease

Journal of Orthopaedic Translation, 2016
Background/Objective: Whole organ in vitro intervertebral disc models have been associated with poor maintenance of cell viability. No previous studies have used a rotating wall vessel bioreactor for intervertebral disc explants culture.
James T. Stannard, Kazuya Edamura, Aaron M. Stoker, Grace D. O'Connell, Keiichi Kuroki, Clark T. Hung, Theodore J. Choma, James L. Cook   +7 more
doaj   +1 more source

Evaluation of the influence of kyphosis and scoliosis on intervertebral disc extrusion in French bulldogs

BMC Veterinary Research, 2018
Background Although thoracic vertebral malformations with kyphosis and scoliosis are often considered incidental findings on diagnostic imaging studies of screw-tailed brachycephalic breeds, they have been suggested to interfere with spinal biomechanics ...
Maria Claudia C. M. Inglez de Souza, Richard Ryan, Gert ter Haar, Rowena M. A. Packer, Holger A. Volk, Steven De Decker   +5 more
doaj   +1 more source