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Intestinal Barrier Repair in Giardiasis
The Journal of Immunology, 2023Abstract Giardiasis is a common diarrheal disease caused by the protozoan parasite Giardia duodenalis. Acute symptoms can include diarrhea, but infections are often sub-clinical. It is transmitted via ingesting infectious cysts in contaminated food or water.
Rita Taye Kosile +3 more
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Intestinal Inflammation and Mucosal Barrier Function
Inflammatory Bowel Diseases, 2014Intestinal mucosal barrier function is the capacity of the intestine to provide adequate containment of luminal microorganisms and molecules while preserving the ability to absorb nutrients. The central element is the epithelial layer, which physically separates the lumen and the internal milieu and is in charge of vectorial transport of ions ...
Fermín, Sánchez de Medina +3 more
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Intestinal barriers protect against disease
Science, 2018Leaky cell-cell junctions contribute to inflammatory and autoimmune ...
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Nitric Oxide and Intestinal Barrier Failure
Seminars in Pediatric Surgery, 1999The systemic inflammatory response syndrome (SIRS) is a leading cause of morbidity and mortality in adults and children. Various proinflammatory mediators have been implicated in the pathogenesis of SIRS; however, their mechanisms of action are poorly defined.
E P, Nadler +3 more
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Intestinal epithelial barrier functions in ageing
Ageing Research Reviews, 2019The intestinal epithelial barrier protects the mucosa of the gastrointestinal (GI)-tract and plays a key role in maintaining the host homeostasis. It encompasses several elements that include the intestinal epithelium and biochemical and immunological products, such as the mucus layer, antimicrobial peptides (AMPs) and secretory immunologlobulin A ...
Jacopo J V, Branca +2 more
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Bacteria breach intestinal barriers
Science, 2014Gut Microbiota In an ironic complication of liver cirrhosis, beneficial microbes can escape from the gut and cause serious infections—or even death. Balmer et al. now show that the blood vessels of the healthy liver form a barrier to runaway gut bacteria.
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Intestinal Barrier Function and Neurodegenerative Disease
CNS & Neurological Disorders - Drug TargetsAbstract: Neurodegenerative diseases are caused by the loss of neurons and/or their myelin sheaths, which deteriorate over time and become dysfunctional. Alzheimer's disease, Parkinson's disease, and multiple sclerosis are among the most prominent neurodegenerative diseases that affect millions of older adults worldwide.
Shijing, Wu +5 more
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Improvement of a ‘Leaky' Intestinal Barrier
Digestive Diseases, 2017In Crohn's disease, the mucus layer appears to be defective in terms of low defensin levels and lack of antibacterial activity. These deficiencies actually explain the Montreal phenotypes and the stable localization of disease in the terminal ileum with low α-defensins from Paneth cells and/or low β-defensins in colonic disease, respectively ...
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INSECTS' INTESTINAL BARRIER AGAINST INFECTION
Journal of Experimental Biology, 2012![Figure][1] The enormously large and hence vulnerable surface of the vertebrate gastrointestinal tract is largely protected from pathogenic micro-organisms by a mucous matrix made of water, glycoproteins and antimicrobial substances.
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