Results 231 to 240 of about 204,575 (264)
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Pharmacological Targeting of the Inflamed Intestinal Barrier
Current Pharmaceutical Design, 2016The intestinal epithelium serves as an important barrier between luminal contents and underlying tissue compartments. Barrier properties are established and maintained by the multiprotein complexes in the tight junction (TJ), adherens junction (AJ) and desmosomes (DM).
Farkas, Elek Attila, Nusrat, Asma
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Effect of Probiotics on Intestinal Barrier Function
Annals of the New York Academy of Sciences, 2009Impairment of the intestinal barrier is a key event in various gastrointestinal diseases, including inflammatory bowel diseases, celiac disease, gastrointestinal infections, diarrhea, and critical illness. Recent studies demonstrated that probiotic bacteria have beneficial effects in these diseases by effectively improving intestinal barrier function ...
Rudolf, Mennigen, Matthias, Bruewer
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Contribution of microbiota to the intestinal physicochemical barrier
Beneficial Microbes, 2015The large number of intestinal microorganisms, which exceeds the total number of human cells by ten folds, alludes to a significant contribution to human health. This is vivid in enteric and some systemic diseases emanating from disruption of the microbiota.
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Modulation of intestinal barrier properties by miltefosine
Biochemical Pharmacology, 2006Miltefosine (hexadecylphosphocholine, HePC) is the first effective oral agent for the treatment of visceral leishmaniasis. This study aimed to determine whether this oral administration alters the integrity and transport capacities of the intestinal barrier.
Menez, Cécile +4 more
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Nitric Oxide and Intestinal Barrier Failure
Seminars in Pediatric Surgery, 1999The systemic inflammatory response syndrome (SIRS) is a leading cause of morbidity and mortality in adults and children. Various proinflammatory mediators have been implicated in the pathogenesis of SIRS; however, their mechanisms of action are poorly defined.
E P, Nadler +3 more
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Regulation of the intestinal epithelial paracellular barrier
Pharmaceutical Science & Technology Today, 1999Paracellular transport of orally-administered drugs, the passage of molecules between adjacent intestinal epithelial cells, is impeded by a range of structural and functional features found in the intestine. An increased knowledge of the mechanisms that govern the paracellular barrier will enable the pharmaceutical scientist to design novel and ...
, Daugherty, , Mrsny
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The Intestinal Mucus Barrier to Parasites and Bacteria
1982The intestinal mucus layer has been recognised as a layer in which both antibodies are contained1 and microorganisms are trapped2,3,4. we have examined the interrelationship between these three (i.e. intestinal mucus layer, antibodies and microorganisms) using nematode parasite infections of the rat and the resident bacteria of the intestines of man.
G B, Lee, B M, Ogilvie
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Intestinal barriers protect against disease
Science, 2018Leaky cell-cell junctions contribute to inflammatory and autoimmune ...
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Experimental diabetes and intestinal barriers to absorption
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1983The unstirred water layer (UWL) and the brush-border membrane represent the major barriers to intestinal absorption. Enhanced uptake of several nutrients has been described in diabetes mellitus, and this study was undertaken in the rat to define whether these absorptive changes are due to alterations in the characteristics of these barriers.
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