Results 221 to 230 of about 204,575 (264)
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Apoptosis and Intestinal Barrier Function
Annals of the New York Academy of Sciences, 2000The signal transduction pathways of the induction of apoptosis in the gastrointestinal tract have in part been discovered. However, almost nothing is known about the functional influence of apoptotic signals on intestinal barrier function. In this study the effect of camptothecin-induced apoptosis in HT-29/B6 monolayers and the influence of apoptosis ...
C, Bojarski +7 more
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Epithelial Barriers in Intestinal Inflammation
Antioxidants & Redox Signaling, 2011The gastrointestinal epithelium transports solutes and water between lumen and blood and at the same time forms a barrier between these compartments. This highly selective and regulated barrier permits ions, water, and nutrients to be absorbed, but normally restricts the passage of harmful molecules, bacteria, viruses and other pathogens.
Lena J, John +2 more
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Intestinal Barrier and Behavior
2016The intestinal barrier function contributes to gut homeostasis by modulating absorption of water, electrolytes, and nutrients from the lumen into the circulation while restricting the passage of noxious luminal substances and microorganisms. Chronic conditions such as rheumatoid arthritis, inflammatory bowel disease, and celiac disease are associated ...
M, Julio-Pieper, J A, Bravo
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Intestinal Barriers to Bacteria and their Toxins
Annual Review of Medicine, 1990Immunologic and nonimmunologic processes work together to protect the host from the multitude of microorganisms residing within the intestinal lumen. Mechanical integrity of the intestinal epithelium, mucus in combination with secretory antibody, antimicrobial metabolites of indigenous microorganisms, and peristalsis each limit proliferation and ...
R I, Walker, R L, Owen
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The small intestine: barrier, permeability and microbiota
Minerva Gastroenterology, 2022In recent years, there has been growing interest in the comprehension of the physiology of intestinal permeability and microbiota; and how these elements could influence the pathogenesis of diseases. The term intestinal permeability describes all the processes that allow the passage of molecules as water, electrolytes and nutrients through the ...
Francesco M, Stalla +4 more
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NeoReviews, 2009
As the largest interface with the external environment, the mature intestinal epithelium has remarkable physiologic responsibilities. The intestine must function first as an organ of absorption and digestion while simultaneously protecting itself from the vast bacterial flora, array of food antigens, and physiochemical stresses caused by digestive and ...
Nancy A. Louis, Patricia W. Lin
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As the largest interface with the external environment, the mature intestinal epithelium has remarkable physiologic responsibilities. The intestine must function first as an organ of absorption and digestion while simultaneously protecting itself from the vast bacterial flora, array of food antigens, and physiochemical stresses caused by digestive and ...
Nancy A. Louis, Patricia W. Lin
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Improvement of a ‘Leaky' Intestinal Barrier
Digestive Diseases, 2017In Crohn's disease, the mucus layer appears to be defective in terms of low defensin levels and lack of antibacterial activity. These deficiencies actually explain the Montreal phenotypes and the stable localization of disease in the terminal ileum with low α-defensins from Paneth cells and/or low β-defensins in colonic disease, respectively ...
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Intestinal Inflammation and Mucosal Barrier Function
Inflammatory Bowel Diseases, 2014Intestinal mucosal barrier function is the capacity of the intestine to provide adequate containment of luminal microorganisms and molecules while preserving the ability to absorb nutrients. The central element is the epithelial layer, which physically separates the lumen and the internal milieu and is in charge of vectorial transport of ions ...
Fermín, Sánchez de Medina +3 more
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HIV infection and the intestinal mucosal barrier
Annals of the New York Academy of Sciences, 2012HIV infection induces a barrier defect of the intestinal mucosa, which is closely linked to immune activation and CD4 T cell depletion. The HIV‐induced barrier defect is initiated in early acute and maintained through chronic infection. In acute infection, increased epithelial permeability is associated with increased epithelial apoptosis possibly ...
Hans-Jörg, Epple, Martin, Zeitz
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Intestinal Barrier Function and Neurodegenerative Disease
CNS & Neurological Disorders - Drug TargetsAbstract: Neurodegenerative diseases are caused by the loss of neurons and/or their myelin sheaths, which deteriorate over time and become dysfunctional. Alzheimer's disease, Parkinson's disease, and multiple sclerosis are among the most prominent neurodegenerative diseases that affect millions of older adults worldwide.
Shijing, Wu +5 more
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