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The small intestine: barrier, permeability and microbiota
Minerva Gastroenterology, 2022In recent years, there has been growing interest in the comprehension of the physiology of intestinal permeability and microbiota; and how these elements could influence the pathogenesis of diseases. The term intestinal permeability describes all the processes that allow the passage of molecules as water, electrolytes and nutrients through the ...
Francesco M, Stalla +4 more
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NeoReviews, 2009
As the largest interface with the external environment, the mature intestinal epithelium has remarkable physiologic responsibilities. The intestine must function first as an organ of absorption and digestion while simultaneously protecting itself from the vast bacterial flora, array of food antigens, and physiochemical stresses caused by digestive and ...
Nancy A. Louis, Patricia W. Lin
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As the largest interface with the external environment, the mature intestinal epithelium has remarkable physiologic responsibilities. The intestine must function first as an organ of absorption and digestion while simultaneously protecting itself from the vast bacterial flora, array of food antigens, and physiochemical stresses caused by digestive and ...
Nancy A. Louis, Patricia W. Lin
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Intestinal epithelial barrier functions in ageing
Ageing Research Reviews, 2019The intestinal epithelial barrier protects the mucosa of the gastrointestinal (GI)-tract and plays a key role in maintaining the host homeostasis. It encompasses several elements that include the intestinal epithelium and biochemical and immunological products, such as the mucus layer, antimicrobial peptides (AMPs) and secretory immunologlobulin A ...
Jacopo Junio Valerio Branca +2 more
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Improvement of a ‘Leaky' Intestinal Barrier
Digestive Diseases, 2017In Crohn's disease, the mucus layer appears to be defective in terms of low defensin levels and lack of antibacterial activity. These deficiencies actually explain the Montreal phenotypes and the stable localization of disease in the terminal ileum with low α-defensins from Paneth cells and/or low β-defensins in colonic disease, respectively ...
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Pharmacological Targeting of the Inflamed Intestinal Barrier
Current Pharmaceutical Design, 2016The intestinal epithelium serves as an important barrier between luminal contents and underlying tissue compartments. Barrier properties are established and maintained by the multiprotein complexes in the tight junction (TJ), adherens junction (AJ) and desmosomes (DM).
Farkas, Elek Attila, Nusrat, Asma
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Intestinal Inflammation and Mucosal Barrier Function
Inflammatory Bowel Diseases, 2014Intestinal mucosal barrier function is the capacity of the intestine to provide adequate containment of luminal microorganisms and molecules while preserving the ability to absorb nutrients. The central element is the epithelial layer, which physically separates the lumen and the internal milieu and is in charge of vectorial transport of ions ...
Fermín, Sánchez de Medina +3 more
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HIV infection and the intestinal mucosal barrier
Annals of the New York Academy of Sciences, 2012HIV infection induces a barrier defect of the intestinal mucosa, which is closely linked to immune activation and CD4 T cell depletion. The HIV‐induced barrier defect is initiated in early acute and maintained through chronic infection. In acute infection, increased epithelial permeability is associated with increased epithelial apoptosis possibly ...
Hans-Jörg, Epple, Martin, Zeitz
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Effect of Probiotics on Intestinal Barrier Function
Annals of the New York Academy of Sciences, 2009Impairment of the intestinal barrier is a key event in various gastrointestinal diseases, including inflammatory bowel diseases, celiac disease, gastrointestinal infections, diarrhea, and critical illness. Recent studies demonstrated that probiotic bacteria have beneficial effects in these diseases by effectively improving intestinal barrier function ...
Rudolf, Mennigen, Matthias, Bruewer
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Intestinal Barrier Function and Neurodegenerative Disease
CNS & Neurological Disorders - Drug TargetsAbstract: Neurodegenerative diseases are caused by the loss of neurons and/or their myelin sheaths, which deteriorate over time and become dysfunctional. Alzheimer's disease, Parkinson's disease, and multiple sclerosis are among the most prominent neurodegenerative diseases that affect millions of older adults worldwide.
Shijing, Wu +5 more
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Contribution of microbiota to the intestinal physicochemical barrier
Beneficial Microbes, 2015The large number of intestinal microorganisms, which exceeds the total number of human cells by ten folds, alludes to a significant contribution to human health. This is vivid in enteric and some systemic diseases emanating from disruption of the microbiota.
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