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Non-invasive measurement of intestinal barrier function in environmental enteropathy using transcutaneous fluorescence sensing

Monfort-Sanchez E, Mandal N, Mwiinga M, Banda R, Xu J, Mweetwa MN, Phiri TN, Chisenga I, Gan J, Wang Z, Qian J, Agarwal A, Salam A, Gómez-Romero M, Maslen L, Chekmeneva E, Darzi A, Marchesi JR, Avery J, Kelly P, Thompson AJ.   +20 more
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Intestinal epithelial barrier functions in ageing

Ageing Research Reviews, 2019
The intestinal epithelial barrier protects the mucosa of the gastrointestinal (GI)-tract and plays a key role in maintaining the host homeostasis. It encompasses several elements that include the intestinal epithelium and biochemical and immunological products, such as the mucus layer, antimicrobial peptides (AMPs) and secretory immunologlobulin A ...
Jacopo Junio Valerio Branca, Claudio Nicoletti   +1 more
exaly   +3 more sources

Intestinal barrier function

Current Opinion in Clinical Nutrition and Metabolic Care, 2002
Intestinal barrier function regulates transport and host defense mechanisms at the mucosal interface with the outside world. Transcellular and paracellular fluxes are tightly controlled by membrane pumps, ion channels and tight junctions, adapting permeability to physiological needs.
Daniel C, Baumgart, Axel U, Dignass
openaire   +2 more sources

Glutamine and intestinal barrier function

Amino Acids, 2014
The intestinal barrier integrity is essential for the absorption of nutrients and health in humans and animals. Dysfunction of the mucosal barrier is associated with increased gut permeability and development of multiple gastrointestinal diseases. Recent studies highlighted a critical role for glutamine, which had been traditionally considered as a ...
Bin, Wang, Guoyao, Wu, Zhigang, Zhou, Zhaolai, Dai, Yuli, Sun, Yun, Ji, Wei, Li, Weiwei, Wang, Chuang, Liu, Feng, Han, Zhenlong, Wu   +10 more
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Apoptosis and Intestinal Barrier Function

Annals of the New York Academy of Sciences, 2000
The signal transduction pathways of the induction of apoptosis in the gastrointestinal tract have in part been discovered. However, almost nothing is known about the functional influence of apoptotic signals on intestinal barrier function. In this study the effect of camptothecin-induced apoptosis in HT-29/B6 monolayers and the influence of apoptosis ...
C, Bojarski, K, Bendfeldt, A H, Gitter, J, Mankertz, M, Fromm, S, Wagner, E O, Riecken, J D, Schulzke   +7 more
openaire   +2 more sources

Intestinal Barriers to Bacteria and their Toxins

Annual Review of Medicine, 1990
Immunologic and nonimmunologic processes work together to protect the host from the multitude of microorganisms residing within the intestinal lumen. Mechanical integrity of the intestinal epithelium, mucus in combination with secretory antibody, antimicrobial metabolites of indigenous microorganisms, and peristalsis each limit proliferation and ...
R I, Walker, R L, Owen
openaire   +2 more sources

Epithelial Barriers in Intestinal Inflammation

Antioxidants & Redox Signaling, 2011
The gastrointestinal epithelium transports solutes and water between lumen and blood and at the same time forms a barrier between these compartments. This highly selective and regulated barrier permits ions, water, and nutrients to be absorbed, but normally restricts the passage of harmful molecules, bacteria, viruses and other pathogens.
Lena J, John, Michael, Fromm, Jörg-Dieter, Schulzke   +2 more
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Intestinal Barrier and Behavior

2016
The intestinal barrier function contributes to gut homeostasis by modulating absorption of water, electrolytes, and nutrients from the lumen into the circulation while restricting the passage of noxious luminal substances and microorganisms. Chronic conditions such as rheumatoid arthritis, inflammatory bowel disease, and celiac disease are associated ...
M, Julio-Pieper, J A, Bravo
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The small intestine: barrier, permeability and microbiota

Minerva Gastroenterology, 2022
In recent years, there has been growing interest in the comprehension of the physiology of intestinal permeability and microbiota; and how these elements could influence the pathogenesis of diseases. The term intestinal permeability describes all the processes that allow the passage of molecules as water, electrolytes and nutrients through the ...
Francesco M, Stalla, Marco, Astegiano, Davide G, Ribaldone, Giorgio M, Saracco, Rinaldo, Pellicano   +4 more
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