Results 271 to 280 of about 357,808 (308)
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NeoReviews, 2009
As the largest interface with the external environment, the mature intestinal epithelium has remarkable physiologic responsibilities. The intestine must function first as an organ of absorption and digestion while simultaneously protecting itself from the vast bacterial flora, array of food antigens, and physiochemical stresses caused by digestive and ...
Nancy A. Louis, Patricia W. Lin
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As the largest interface with the external environment, the mature intestinal epithelium has remarkable physiologic responsibilities. The intestine must function first as an organ of absorption and digestion while simultaneously protecting itself from the vast bacterial flora, array of food antigens, and physiochemical stresses caused by digestive and ...
Nancy A. Louis, Patricia W. Lin
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Improvement of a ‘Leaky' Intestinal Barrier
Digestive Diseases, 2017In Crohn's disease, the mucus layer appears to be defective in terms of low defensin levels and lack of antibacterial activity. These deficiencies actually explain the Montreal phenotypes and the stable localization of disease in the terminal ileum with low α-defensins from Paneth cells and/or low β-defensins in colonic disease, respectively ...
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HIV infection and the intestinal mucosal barrier
Annals of the New York Academy of Sciences, 2012HIV infection induces a barrier defect of the intestinal mucosa, which is closely linked to immune activation and CD4 T cell depletion. The HIV‐induced barrier defect is initiated in early acute and maintained through chronic infection. In acute infection, increased epithelial permeability is associated with increased epithelial apoptosis possibly ...
Hans-Jörg, Epple, Martin, Zeitz
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Effect of Probiotics on Intestinal Barrier Function
Annals of the New York Academy of Sciences, 2009Impairment of the intestinal barrier is a key event in various gastrointestinal diseases, including inflammatory bowel diseases, celiac disease, gastrointestinal infections, diarrhea, and critical illness. Recent studies demonstrated that probiotic bacteria have beneficial effects in these diseases by effectively improving intestinal barrier function ...
Rudolf, Mennigen, Matthias, Bruewer
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Pharmacological Targeting of the Inflamed Intestinal Barrier
Current Pharmaceutical Design, 2016The intestinal epithelium serves as an important barrier between luminal contents and underlying tissue compartments. Barrier properties are established and maintained by the multiprotein complexes in the tight junction (TJ), adherens junction (AJ) and desmosomes (DM).
Farkas, Elek Attila, Nusrat, Asma
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Intestinal Barrier Function and Neurodegenerative Disease
CNS & Neurological Disorders - Drug TargetsAbstract: Neurodegenerative diseases are caused by the loss of neurons and/or their myelin sheaths, which deteriorate over time and become dysfunctional. Alzheimer's disease, Parkinson's disease, and multiple sclerosis are among the most prominent neurodegenerative diseases that affect millions of older adults worldwide.
Shijing, Wu +5 more
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Intestinal Inflammation and Mucosal Barrier Function
Inflammatory Bowel Diseases, 2014Intestinal mucosal barrier function is the capacity of the intestine to provide adequate containment of luminal microorganisms and molecules while preserving the ability to absorb nutrients. The central element is the epithelial layer, which physically separates the lumen and the internal milieu and is in charge of vectorial transport of ions ...
Fermín, Sánchez de Medina +3 more
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Contribution of microbiota to the intestinal physicochemical barrier
Beneficial Microbes, 2015The large number of intestinal microorganisms, which exceeds the total number of human cells by ten folds, alludes to a significant contribution to human health. This is vivid in enteric and some systemic diseases emanating from disruption of the microbiota.
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Modulation of intestinal barrier properties by miltefosine
Biochemical Pharmacology, 2006Miltefosine (hexadecylphosphocholine, HePC) is the first effective oral agent for the treatment of visceral leishmaniasis. This study aimed to determine whether this oral administration alters the integrity and transport capacities of the intestinal barrier.
Menez, Cécile +4 more
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The Intestinal Mucus Barrier to Parasites and Bacteria
1982The intestinal mucus layer has been recognised as a layer in which both antibodies are contained1 and microorganisms are trapped2,3,4. we have examined the interrelationship between these three (i.e. intestinal mucus layer, antibodies and microorganisms) using nematode parasite infections of the rat and the resident bacteria of the intestines of man.
G B, Lee, B M, Ogilvie
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