Celiac Disease Monocytes Induce a Barrier Defect in Intestinal Epithelial Cells [PDF]
, 2019 Intestinal epithelial barrier function in celiac disease (CeD) patients is altered. However, the mechanism underlying this effect is not fully understood.
Branchi, Federica +6 more
core +1 more source
TNFAIP3 maintains intestinal barrier function and supports epithelial cell tight junctions. [PDF]
PLoS ONE, 2011 Tight junctions between intestinal epithelial cells mediate the permeability of the intestinal barrier, and loss of intestinal barrier function mediated by TNF signaling is associated with the inflammatory pathophysiology observed in Crohn's disease and ...
Lauren E Kolodziej +11 more
doaj +1 more source
Histopathology of the gut in rheumatic diseases [PDF]
, 2018 The gastrointestinal tract regulates the trafficking of macromolecules between the environment and the host through an epithelial barrier mechanism and is an important part of the immune system controlling the equilibrium between tolerance and immunity ...
Ciccia F. +4 more
core +1 more source
Inorganic arsenic causes intestinal barrier disruption [PDF]
Metallomics, 2019 Abstract Inorganic arsenic (As) is the most toxic form of As found in food and water. Gastrointestinal disorders have been reported in populations chronically exposed to this arsenical form or to one of its metabolites; however, studies to determine the mechanisms of inorganic As toxicity at the intestinal level are scarce.
Gabriela M Chiocchetti +2 more
openaire +3 more sources
IL-1β and the Intestinal Epithelial Tight Junction Barrier
Frontiers in Immunology, 2021 The intestinal epithelial tight junction (TJ) barrier controls the paracellular permeation of contents from the intestinal lumen into the intestinal tissue and systemic circulation.
Lauren W. Kaminsky +2 more
doaj +1 more source
LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. [PDF]
, 2018 Epithelial dysfunction and crypt destruction are defining features of inflammatory bowel disease (IBD). However, current IBD therapies targeting epithelial dysfunction are lacking.
Bayrer, James R +8 more
core +2 more sources
Intestinal barriers to water-soluble macromolecules [PDF]
Environmental Health Perspectives, 1979 Neonates of some species of mammals absorb water-soluble macromolecules from the lumen of the gut to the circulation. This is a means for providing the neonate with passive immunological protection. The accepted model for absorption of macromolecules, particularly immunoglobulin G (IgG), has at least three phases: adherence of the macromolecule to the ...
openaire +2 more sources
The Role of Intestinal Mucosal Barrier in Autoimmune Disease: A Potential Target
Frontiers in Immunology, 2022 Autoimmune diseases are a series of diseases involving multiple tissues and organs, characterized by the over production of abnormal multiple antibodies.
Jia An +7 more
doaj +1 more source
Biomarkers for monitoring intestinal health in poultry : present status and future perspectives [PDF]
, 2018 Intestinal health is determined by host (immunity, mucosal barrier), nutritional, microbial and environmental factors. Deficiencies in intestinal health are associated with shifts in the composition of the intestinal microbiome (dysbiosis), leakage of ...
Antonissen, Gunther +6 more
core +3 more sources
PLK1 protects against sepsis-induced intestinal barrier dysfunction
Scientific Reports, 2018 Sepsis and sepsis-associated intestinal barrier dysfunction are common in intensive care units, with high mortality. The aim of this study is to investigate whether Polo-like kinase 1 (PLK1) ameliorates sepsis-induced intestinal barrier dysfunction in ...
Yingya Cao +7 more
doaj +1 more source