Results 101 to 110 of about 539,014 (352)

Chitosan Ameliorates DSS-Induced Ulcerative Colitis Mice by Enhancing Intestinal Barrier Function and Improving Microflora

International Journal of Molecular Sciences, 2019
Ulcerative colitis (UC) has been identified as one of the inflammatory diseases. Intestinal mucosal barrier function and microflora play major roles in UC. Modified-chitosan products have been consumed as effective and safe drugs to treat UC. The present
Jia Wang, Cuili Zhang, Chunmei Guo, Xinli Li   +3 more
semanticscholar   +1 more source

Intestinal barrier function is maintained with aging – a comprehensive study in healthy subjects and irritable bowel syndrome patients

Scientific Reports, 2020
Animal studies have shown that intestinal barrier function is compromised with aging. We aimed to assess the effects of aging on intestinal barrier function in humans in vivo and ex vivo.
E. Wilms, F. Troost, M. Elizalde, B. Winkens, P. de Vos, Z. Mujagic, D. Jonkers, A. Masclee   +7 more
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Oral supplementation with non-absorbable antibiotics or curcumin attenuates western diet-induced atherosclerosis and glucose intolerance in LDLR-/- mice--role of intestinal permeability and macrophage activation.

PLoS ONE, 2014
Association between circulating lipopolysaccharide (LPS) and metabolic diseases (such as Type 2 Diabetes and atherosclerosis) has shifted the focus from Western diet-induced changes in gut microbiota per se to release of gut bacteria-derived products ...
Siddhartha S Ghosh, Jinghua Bie, Jing Wang, Shobha Ghosh   +3 more
doaj   +1 more source

A human colonic crypt culture system to study regulation of stem cell-driven tissue renewal and physiological function [PDF]

, 2015
The intestinal epithelium is one of the most rapidly renewing tissues in the human body and fulfils vital physiological roles such as barrier function and transport of nutrients and fluid.
A Reynolds, A Reynolds, C Kosinski, CL Watson, E Batlle, J Grossmann, J Strater, JR Spence, L Vermeulen, M Wetering van de, N Barker, P Jung, PR Gibson, RH Whitehead, S Yui, T Sato, T Sato, T Sato, T Sato   +18 more
core   +1 more source

Mast cells-derived MiR-223 destroys intestinal barrier function by inhibition of CLDN8 expression in intestinal epithelial cells

Biological Research, 2020
Mast cells (MCs) have been found to play a critical role during development of inflammatory bowel disease (IBD) that characterized by dysregulation of inflammation and impaired intestinal barrier function.
Musheng Li, Junhong Zhao, Meiwan Cao, Ruitao Liu, Guanhua Chen, Songyu Li, Yuanwen Xie, Jing Xie, Yang Cheng, Ling Huang, Mingmin Su, Yuxin Xu, Mingyue Zheng, K. Zou, L. Geng, Wanfu Xu, S. Gong   +16 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circ-0000197 derived from porcine milk small extracellular vesicles promotes intestinal barrier function by sponging miR-429

Journal of Animal Science and Biotechnology
Background As an essential source of nutrients for young mammals, milk possesses a variety of biological functions. Recently identified milk-derived small extracellular vesicles (sEV) have shown potential regulatory effects on intestinal health.
Yuxuan Wang, Bilan Chen, Tingzhou Xuan, Kun Ouyang, Jingshen Chen, Hailong Wang, Junyi Luo, Jiajie Sun, Qianyun Xi, Yongliang Zhang, Ting Chen   +10 more
doaj   +1 more source

Intestinal epithelial responses to Salmonella enterica serovar Enteritidis: Effects on intestinal permeability and ion transport [PDF]

, 2019
Salmonella infection of chickens that leads to potential human foodborne salmonellosis continues to be a major concern. Chickens serve as carriers but, in contrast to humans, rarely show any clinical signs including diarrhea.
Aschenbach, J. R., Awad, W. A., Hess, C., Hess, M., Khayal, B.   +4 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source