Results 311 to 320 of about 539,014 (352)

High-Throughput Screen Identifies Host and Microbiota Regulators of Intestinal Barrier Function.

Gastroenterology, 2020
BACKGROUND & AIMS The intestinal barrier protects intestinal cells from microbes and antigens in the lumen-breaches can alter the composition of the intestinal microbiota, the enteric immune system, and metabolism.
I. Grosheva, D. Zheng, M. Levy, Omer Polansky, A. Lichtenstein, O. Golani, Mally Dori-Bachash, C. Moresi, H. Shapiro, Sara Del Mare-Roumani, R. Valdés-Mas, Yiming He, Hodaya Karbi, Minhu Chen, A. Harmelin, R. Straussman, N. Yissachar, E. Elinav, B. Geiger   +18 more
semanticscholar   +1 more source

Nitric Oxide Directly Impairs Intestinal Barrier Function

Shock, 2002
Excess production of nitric oxide (NO) has been implicated in endotoxin-induced loss of gut barrier function in vivo. Thus, we tested the direct effect of NO on the barrier function of intestinal mucosal membranes suspended ex vivo in Ussing chambers and on IEC-6 enterocyte monolayers. In these experiments, ex vivo-mounted ileal membranes or IEC-6 cell
Da-Zhong, Xu, Qi, Lu, Edwin A, Deitch
openaire   +2 more sources

Effect of Probiotics on Intestinal Barrier Function

Annals of the New York Academy of Sciences, 2009
Impairment of the intestinal barrier is a key event in various gastrointestinal diseases, including inflammatory bowel diseases, celiac disease, gastrointestinal infections, diarrhea, and critical illness. Recent studies demonstrated that probiotic bacteria have beneficial effects in these diseases by effectively improving intestinal barrier function ...
Rudolf, Mennigen, Matthias, Bruewer
openaire   +2 more sources

II. Stress and intestinal barrier function

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2001
The influence of stress on the clinical course of a number of intestinal diseases is increasingly being recognized, but the underlying mechanisms are largely unknown. This themes article focuses on recent findings related to the effects of stress on mucosal barrier function in the small intestine and colon.
Johan D. Söderholm, Mary H. Perdue
openaire   +1 more source

Intestinal barrier function in patients undergoing colectomy.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2011
The aim of this pilot study was to determine whether the type of approach (open or laparoscopic) and the order of devascularization during laparoscopic colectomy affect intestinal barrier function, local inflammatory response and clinical outcome.Twenty-two patients undergoing elective colectomy from April 2006 to July 2008 were randomized to two ...
Vlug, M. S., Diepenhorst, G. M. P., van Koperen, P. J., Renooij, W., de Smet, M. B. M., Slors, J. F. M., Boermeester, M. A., Bemelman, W. A.   +7 more
openaire   +2 more sources

Restoration of Barrier Function in Injured Intestinal Mucosa

Physiological Reviews, 2007
Mucosal repair is a complex event that immediately follows acute injury induced by ischemia and noxious luminal contents such as bile. In the small intestine, villous contraction is the initial phase of repair and is initiated by myofibroblasts that reside immediately beneath the epithelial basement membrane.
Anthony T, Blikslager, Adam J, Moeser, Jody L, Gookin, Samuel L, Jones, Jack, Odle   +4 more
openaire   +2 more sources

Biomarkers of intestinal barrier function in multiple sclerosis are associated with disease activity

Multiple Sclerosis, 2020
Background: Recent evidence suggests a role for the gut–brain axis in the pathophysiology of multiple sclerosis (MS). Materials and methods: We studied biomarkers of intestinal permeability in 126 people with MS (57 relapsing-remitting multiple sclerosis
C. Cámara-Lemarroy, Cláudia Silva, J. Greenfield, Wei-Qiao Liu, L. Metz, V. W. Yong   +5 more
semanticscholar   +1 more source

Role of M Cells in Intestinal Barrier Function

Annals of the New York Academy of Sciences, 2000
Abstract:M cells are known as specialized epithelial cells of the follicle‐associated epithelium of the gastrointestinal tract. As M cells have a high capacity for transcytosis of a wide range of microorganisms and macromolecules, they are believed to act as an antigen sampling system.
T, Kucharzik, N, Lügering, K, Rautenberg, A, Lügering, M A, Schmidt, R, Stoll, W, Domschke   +6 more
openaire   +2 more sources

Ferulic acid improves intestinal barrier function through altering gut microbiota composition in high-fat diet-induced mice

European Journal of Nutrition, 2022
Baoming Tian, Y. Geng, Peiyi Wang, Ming Cai, Jing Neng, Jiangning Hu, Daozong Xia, Wangli Cao, Kai Yang, Peilong Sun   +9 more
semanticscholar   +1 more source

Intestinal Barrier Function and Secretion in Methotrexate-Induced Rat Intestinal Mucositis

Digestive Diseases and Sciences, 2004
Chemotherapy-induced mucositis is an important dose-limiting and costly side effect for which there is no definitive prophylaxis or treatment. This is due in part to the lack of understanding of its pathophysiology and impact on intestinal function. The objectives of this study were to investigate the small intestine barrier function and electrolyte ...
B A, Carneiro-Filho, I P F, Lima, D H, Araujo, M C, Cavalcante, G H P, Carvalho, G A C, Brito, V, Lima, S M N, Monteiro, F N, Santos, R A, Ribeiro, A A M, Lima   +10 more
openaire   +2 more sources