Results 61 to 70 of about 539,014 (352)

Intestinal Mucin Glycosylation: Structural Regulation, Homeostasis Maintenance and Disease Association

Biomolecules
The intestinal barrier is a complex configuration that defends against external assaults and maintains intestinal health. Disruption of barrier function can lead to intestinal inflammation and various diseases.
Yunye Li, Jia Pan, Huimin Liu, Chuanguo Liu   +3 more
doaj   +1 more source

Differences in intestinal size, structure, and function contributing to feed efficiency in broiler chickens reared at geographically distant locations [PDF]

, 2019
The contribution of the intestinal tract to differences in residual feed intake (RFI) has been inconclusively studied in chickens so far. It is also not clear if RFI-related differences in intestinal function are similar in chickens raised in different ...
Aschenbach, J., Ball, M. E. E., Ertl, R., Hawken, R. J., Hollmann, M., Lawlor, P. G. [u.v.m.], Magowan, E., Metzler-Zebeli, B. U., Molnár, A., Witter, K.   +9 more
core   +1 more source

Intestinal barrier function: Molecular regulation and disease pathogenesis [PDF]

Journal of Allergy and Clinical Immunology, 2009
The intestinal epithelium is a single-cell layer that constitutes the largest and most important barrier against the external environment. It acts as a selectively permeable barrier, permitting the absorption of nutrients, electrolytes, and water while maintaining an effective defense against intraluminal toxins, antigens, and enteric flora.
Katherine R, Groschwitz, Simon P, Hogan
openaire   +2 more sources

Delivery of Berberine Using Chitosan/Fucoidan-Taurine Conjugate Nanoparticles for Treatment of Defective Intestinal Epithelial Tight Junction Barrier [PDF]

, 2014
[[abstract]]Bacterial-derived lipopolysaccharides (LPS) can cause defective intestinal barrier function and play an important role in the development of inflammatory bowel disease. In this study, a nanocarrier based on chitosan and fucoidan was developed
Ale, Cheng-Wei Lin, Cuzzocrea, Fwu-Long Mi, Huang, Rao, Shao-Jung Wu, Trong-Ming Don   +7 more
core   +2 more sources

Progress in Mycotoxins Affecting Intestinal Mucosal Barrier Function [PDF]

International Journal of Molecular Sciences, 2019
Mycotoxins, which are widely found in feed ingredients and human food, can exert harmful effects on animals and pose a serious threat to human health. As the first barrier against external pollutants, the intestinal mucosa is protected by a mechanical barrier, chemical barrier, immune barrier, and biological barrier. Firstly, mycotoxins can disrupt the
Zhihua Ren, Chaoyue Guo, Shumin Yu, Ling Zhu, Ya Wang, Hui Hu, Junliang Deng   +6 more
openaire   +2 more sources

A Simulated Microgravity Environment Causes a Sustained Defect in Epithelial Barrier Function. [PDF]

, 2019
Intestinal epithelial cell (IEC) junctions constitute a robust barrier to invasion by viruses, bacteria and exposure to ingested agents. Previous studies showed that microgravity compromises the human immune system and increases enteropathogen virulence.
Alvarez, Rocio, Marchelletta, Ronald R, McCole, Declan F, Prisk, G Kim, Sayoc-Becerra, Anica, Stork, Cheryl A   +5 more
core   +1 more source

A novel function for the Caenorhabditis elegans torsin OOC-5 in nucleoporin localization and nuclear import. [PDF]

, 2015
Torsin proteins are AAA+ ATPases that localize to the endoplasmic reticular/nuclear envelope (ER/NE) lumen. A mutation that markedly impairs torsinA function causes the CNS disorder DYT1 dystonia. Abnormalities of NE membranes have been linked to torsinA
Dauer, William T, Hall, David H, Nguyen, Ken CQ, Rose, Lesilee S, VanGompel, Michael JW   +4 more
core   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Intestine‐Specific Expression of Human Chimeric Intestinal Alkaline Phosphatase Attenuates Western Diet‐Induced Barrier Dysfunction and Glucose Intolerance [PDF]

, 2018
Intestinal epithelial cell derived alkaline phosphatase (IAP) dephosphorylates/detoxifies bacterial endotoxin lipopolysaccharide (LPS) in the gut lumen.
Ghosh, Shobha, Ghosh, Siddhartha S., He, Hongliang, Korzun, William, Wang, Jing, Yannie, Paul J.   +5 more
core   +1 more source

Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function [PDF]

World Journal of Gastroenterology, 2007
To test the hypothesis that hydrolysis of sphingomyelin to ceramide changes the composition of tight junctions (TJs) with increasing permeability of the intestinal epithelium.Monolayers of Caco-2 cells were used as an in vitro model for the intestinal barrier.
Jurgen, Bock, Gerhard, Liebisch, Joachim, Schweimer, Gerd, Schmitz, Gerhard, Rogler   +4 more
openaire   +2 more sources