Results 81 to 90 of about 544,713 (308)

Neuronal innervation of the intestinal crypt

, 2021
Mucosal damage is a key feature of inflammatory bowel diseases (IBD) and healing of the mucosa is an endpoint of IBD treatment that is often difficult to achieve.
Seppen, Jurgen, ten Hove, Anne S., de Jonge, Wouter J.   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Additive effects of fecal microbiota transplantation and infliximab on gut microbiome and metabolome in refractory inflammatory bowel disease patients

mSystems
Fecal microbiota transplantation (FMT) is an emerging therapy for inflammatory bowel disease (IBD), yet its efficacy in patients refractory to conventional treatments and its underlying mechanisms require further elucidation.
Xinjun Wang, Weijun Wu, Bo Yang, Yunkun Liu, Yue Xu, Le Wang, Xiaoqiong Lv, Junhui Gao, Man Lu, Anqi Yu, Ning Li, Qiyi Chen, Liesheng Lu, Di Zhao   +13 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Risk of intestinal parasitic infections in people with different exposures to wastewater and fecal sludge in Kampala, Uganda : a cross-sectional study [PDF]

, 2016
There are health risks associated with wastewater and fecal sludge management and use, but little is known about the magnitude, particularly in rapidly growing urban settings of low- and middle-income countries.
Christian Schindler (71594), Rutebemberwa, Elizeus, Utzinger, Jürg, Winkler, Mirko S., Narcis B Kabatereine, Halage, Abdulla A., Christian Schindler, Edridah M. Tukahebwa (437664), Edridah M Tukahebwa, Guéladio Cissé, Jürg Utzinger, Abdulla A. Halage (2552416), Mirko S Winkler, Narcis B. Kabatereine (115496), Kabatereine, Narcis B., Samuel Fuhrimann (2552419), Medlicott, Kate, Kate Medlicott (2552422), Samuel Fuhrimann, Abdulla A Halage, Elizeus Rutebemberwa, Jürg Utzinger (39609), Tukahebwa, Edridah M., Elizeus Rutebemberwa (303039), Guéladio Cissé (844269), Mirko S. Winkler (2552425), Cissé, Guéladio, Schindler, Christian, Kate Medlicott, Fuhrimann, Samuel   +29 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Isolation of Serpulina pilosicoli from rectal biopsy specimens showing evidence of intestinal spirochetosis

, 1998
Histologic evidence of intestinal spirochetosis (IS) was found in 22 of 41 (53.7%) rectal biopsy specimens from homosexual men attending a sexually transmitted diseases clinic. Serpulina pilosicoli was cultured from 11 of the IS-positive biopsy specimens
Gilbert, G.L., Trivett-Moore, N.L., Hampson, D.J., Law, C.L.H., Trott, D.J.   +4 more
core  

Early Ustekinumab Use Improves Clinical Outcomes in Biologic-Naive Crohn’s Disease Patients: A Retrospective Multicenter Cohort Study in Taiwan

Biomedicines
Background/Objectives: Crohn’s disease (CD) is a progressive condition, and early treatment with infliximab combined with an immunosuppressant within six months has been shown to improve clinical outcomes.
Yen-Cheng Chang, Chiao-Hsiung Chuang, Tien-Yu Huang, Chen-Shuan Chung, Chia-Jung Kuo, Yu-Bin Pan, Puo-Hsien Le   +6 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

GLP-1 and Intestinal Diseases

, 2021
Accumulating evidence implicates glucagon-like peptide-1 (GLP-1) to have, beyond glucose maintenance, a beneficial role in the gastrointestinal tract.
Hannelouise Kissow, Kissow, Hannelouise, Palle Bekker Jeppesen, Jens Juul Holst, Jenna Elizabeth Hunt, Holst, Jens Juul, Hunt, Jenna Elizabeth, Jeppesen, Palle Bekker   +7 more
core   +1 more source