Results 71 to 80 of about 3,100,266 (306)

Effects of parasitic infections on clinical outcomes, self-rated quality of life and physical fitness in Côte d'Ivoire [PDF]

, 2014
Background: Hundreds of millions of people in the developing world are at risk of parasitic diseases, such as malaria and neglected tropical diseases (NTDs). Health implications due to these diseases are manifold.
Hürlimann, Eveline
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

JNK Pathway-Associated Phosphatase/DUSP22 Suppresses CD4+ T-Cell Activation and Th1/Th17-Cell Differentiation and Negatively Correlates with Clinical Activity in Inflammatory Bowel Disease

Frontiers in Immunology, 2017
This study aimed to investigate the role of JNK pathway-associated phosphatase (JKAP) in inflammatory bowel disease (IBD). JKAP expression was analyzed in the intestinal mucosa of 81 IBD patients and 25 healthy controls (HCs) by qPCR and immunoblotting ...
Rui Zhou, Rui Zhou, Ying Chang, Ying Chang, Jing Liu, Jing Liu, Min Chen, Min Chen, Hongling Wang, Hongling Wang, Meifang Huang, Meifang Huang, Shi Liu, Shi Liu, Xiaobing Wang, Xiaobing Wang, Qiu Zhao, Qiu Zhao   +17 more
doaj   +1 more source

Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers

Nature Communications, 2021
Active enhancers are still understudied in colorectal cancers (CRC). Here the authors analyse active enhancers in CRC patients using genomics, transcriptomics, and epigenomics, identifying and validating variant super-enhancer loci as well as KLF3 as a ...
Qing-Lan Li, Xiang Lin, Ya-Li Yu, Lin Chen, Qi-Xin Hu, Meng Chen, Nan Cao, Chen Zhao, Chen-Yu Wang, Cheng-Wei Huang, Lian-Yun Li, Mei Ye, Min Wu   +12 more
doaj   +1 more source

Chronic Intestinal Inflammation and Intestinal Disease in Dogs [PDF]

Journal of Veterinary Internal Medicine, 2003
Abstract Normal individuals maintain tolerance to the endogenous bacterial flora residing within their alimentary tract, a phenomenon mediated by the gastrointestinal lymphoid tissue. Loss of this tolerance is a key factor in the development of chronic intestinal inflammation. Manifestations of such uncontrolled inflammation in humans
A J, German, E J, Hall, M J, Day
openaire   +2 more sources

Microbiome modulates intestinal homeostasis against inflammatory diseases [PDF]

, 2018
Eliminating prophylactic antibiotics in food animal production has exerted pressure on discovering antimicrobial alternatives (e.g. microbiome) to reduce elevated intestinal diseases.
NC DOCKS at The University of North Carolina at Greensboro, Jia, Zhenquan   +1 more
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Intestinal Microecology in Pediatric Surgery-Related Gastrointestinal Diseases Current Insights and Future Perspectives [PDF]

, 2023
Intestinal microecology is established from birth and is constantly changing until homeostasis is reached. Intestinal microecology is involved in the immune inflammatory response of the intestine and regulates the intestinal barrier function.
Li, Yingchao, Wu, Yuqing, Li, Suolin, Zhang, Xiaoyi, Lv, Jiaxun, Liu, Lin, Li, Qinqin   +6 more
core   +1 more source

Bowel Sounds Detection Method Based on ResNet-BiLSTM and Attention Mechanism

Zhongguo yiliao qixie zazhi
Bowel sounds can reflect the movement and health status of the gastrointestinal tract. However, the traditional manual auscultation method has subjective deviation and is time-consuming and labor-intensive. In order to better assist doctors in diagnosing
Yali HAO, Xianrong WAN, Congqing JIANG, Xianghai REN, Xiaoming ZHANG, Xiang ZHAI   +5 more
doaj   +1 more source