Results 51 to 60 of about 544,713 (308)

Gut microbiome and bile acids in obesity-related diseases [PDF]

, 2021
Dysbiosis has been implemented in the etiologies of obesity-related chronic diseases such as type 2 diabetes, NAFLD and cardiovascular diseases. Bile acids, a class of amphipathic steroids produced in the liver and extensively modified by the microbiome,
Fu, Jingyuan, Fu, Jingyuan; id_orcid, Kuipers, Folkert, Andreu-Sánchez, Sergio, Andreu-Sánchez, Sergio; id_orcid, Li, Rumei; id_orcid, Kuipers, Folkert; id_orcid, Li, Rumei   +7 more
core   +1 more source

Integrated analysis of serum metabolomics and fecal microbiome in infants with necrotizing enterocolitis

Frontiers in Microbiology
BackgroundNecrotizing enterocolitis (NEC), a lethal gastrointestinal disorder in preterm infants, remains poorly understood in its pathology, and early diagnosis are critically limited.
Zhi-ying Lin, Zhi-ying Lin, Shan-shan He, Zi-tong Mo, Xiao-tian Liao, Zhou-shan Feng, Juan Kong, Lu Zhu, Ying Li, Hui-yuan Tan, Zhi-wen Su, Chun-hong Jia, Chun-hong Jia, Fan Wu, Fan Wu   +14 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The effect of incubator humidity on morbidity and mortality in preterm infants: a systematic review

BMC Pediatrics
Purpose To assess the association between different incubator humidity levels and clinical outcomes in preterm infants. Background Since there is no well-accepted standard for delivery of incubator humidity for preterm infants.
Zhiqin Chen, Ruizi Lin, Huixin Wang, Bijun Shi, Qian Chen   +4 more
doaj   +1 more source

Diet was less significant than physical activity in the prognosis of people with sarcopenia and metabolic dysfunction-associated fatty liver diseases: Analysis of the National Health and Nutrition Examination Survey III

Frontiers in Endocrinology, 2023
BackgroundSarcopenia is prevalent in metabolic dysfunction-associated fatty liver diseases (MAFLD), and the primary treatment for both diseases is lifestyle modification.
Yun Yi, Yun Yi, Chun Wang, Chun Wang, Yang Ding, Yang Ding, JiangHua He, JiangHua He, YuQing Lv, YuQing Lv, Ying Chang, Ying Chang   +11 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers

Nature Communications, 2021
Active enhancers are still understudied in colorectal cancers (CRC). Here the authors analyse active enhancers in CRC patients using genomics, transcriptomics, and epigenomics, identifying and validating variant super-enhancer loci as well as KLF3 as a ...
Qing-Lan Li, Xiang Lin, Ya-Li Yu, Lin Chen, Qi-Xin Hu, Meng Chen, Nan Cao, Chen Zhao, Chen-Yu Wang, Cheng-Wei Huang, Lian-Yun Li, Mei Ye, Min Wu   +12 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

JNK Pathway-Associated Phosphatase/DUSP22 Suppresses CD4+ T-Cell Activation and Th1/Th17-Cell Differentiation and Negatively Correlates with Clinical Activity in Inflammatory Bowel Disease

Frontiers in Immunology, 2017
This study aimed to investigate the role of JNK pathway-associated phosphatase (JKAP) in inflammatory bowel disease (IBD). JKAP expression was analyzed in the intestinal mucosa of 81 IBD patients and 25 healthy controls (HCs) by qPCR and immunoblotting ...
Rui Zhou, Rui Zhou, Ying Chang, Ying Chang, Jing Liu, Jing Liu, Min Chen, Min Chen, Hongling Wang, Hongling Wang, Meifang Huang, Meifang Huang, Shi Liu, Shi Liu, Xiaobing Wang, Xiaobing Wang, Qiu Zhao, Qiu Zhao   +17 more
doaj   +1 more source