Results 61 to 70 of about 3,100,266 (306)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Integrated analysis of serum metabolomics and fecal microbiome in infants with necrotizing enterocolitis

Frontiers in Microbiology
BackgroundNecrotizing enterocolitis (NEC), a lethal gastrointestinal disorder in preterm infants, remains poorly understood in its pathology, and early diagnosis are critically limited.
Zhi-ying Lin, Zhi-ying Lin, Shan-shan He, Zi-tong Mo, Xiao-tian Liao, Zhou-shan Feng, Juan Kong, Lu Zhu, Ying Li, Hui-yuan Tan, Zhi-wen Su, Chun-hong Jia, Chun-hong Jia, Fan Wu, Fan Wu   +14 more
doaj   +1 more source

A Review of Colonoscopy in Intestinal Diseases

, 2023
Since the development of the fiberoptic colonoscope in the late 1960s, colonoscopy has been a useful tool to diagnose and treat various intestinal diseases.
Dong Baek, Seung Hong, Seung Min Hong, Dong Hoon Baek, Baek, Dong Hoon, Hong, Seung Min   +5 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Natural history of intestinal failure, investigated through a network-based approach.

, 2003
OBJECTIVES: Intestinal failure (IF) is a condition whose treatment requires advanced knowledge and techniques and a multidisciplinary approach. Intestinal failure is the endpoint of many intestinal diseases and may result in full recovery, in life-long ...
DE MARCO G, FOR THE ITALIAN NATIONAL NETWORK FOR PEDIATRIC INTESTINAL FAILURE, GUARINO, ALFREDO   +2 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Intestinal barrier and dermatological diseases

, 2021
The purpose of the review is to analyze the literature data on the relationship between intestinal microbiocenosis disorders and skin diseases, as well as the effect of diet on the skin condition and features of the course of certain dermatological ...
V. A. Okhlopkov, A. V. Lyalukov, E. N. Chernysheva, E. A. Lyalyukova, E. V. Nadey   +4 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An Integrated Dataset of Clinical and Microbial Profiles for Fecal Microbiota Transplantation

Scientific Data
Functional gastrointestinal disorders (FGIDs) are prevalent and burdensome, yet progress in microbiota-targeted therapies such as fecal microbiota transplantation (FMT) has been hampered by the lack of large-scale, integrated datasets.
Sen Yan, Le Wang, Yue Xu, Wanyong Zhu, Ning Li, Qiyi Chen, Long Li   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source