Results 91 to 100 of about 201,161 (293)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon

Nature Communications, 2022
DNA methyltransferase 3 A (DNMT3A) is involved in DNA methylation, and genetic variants in the DNMT3 locus have been associated with inflammatory bowel disease.
Antonella Fazio, Dora Bordoni, Jan W. P. Kuiper, Saskia Weber-Stiehl, Stephanie T. Stengel, Philipp Arnold, David Ellinghaus, Go Ito, Florian Tran, Berith Messner, Anna Henning, Joana P. Bernardes, Robert Häsler, Anne Luzius, Simon Imm, Finn Hinrichsen, Andre Franke, Samuel Huber, Susanna Nikolaus, Konrad Aden, Stefan Schreiber, Felix Sommer, Gioacchino Natoli, Neha Mishra, Philip Rosenstiel   +24 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

The role of mucosal immunity in the pathogenesis of necrotizing enterocolitis [PDF]

, 2017
Necrotizing enterocolitis (NEC) is the most devastating gastrointestinal disease of prematurity. Although the precise cause is not well understood, the main risk factors thought to contribute to NEC include prematurity, formula feeding, and bacterial ...
Bolock, Alexa M, Good, Misty, Hodzic, Zerina   +2 more
core   +2 more sources

Intestinal epithelial barrier and neuromuscular compartment in health and disease

World Journal of Gastroenterology, 2020
A number of digestive and extra-digestive disorders, including inflammatory bowel diseases, irritable bowel syndrome, intestinal infections, metabolic syndrome and neuropsychiatric disorders, share a set of clinical features at gastrointestinal level, such as infrequent bowel movements, abdominal distension, constipation and secretory dysfunctions ...
D'Antongiovanni V., Pellegrini C., Fornai M., Colucci R., Blandizzi C., Antonioli L., Bernardini N.   +6 more
openaire   +3 more sources

Metabolic regulation of intestinal epithelial barrier during inflammation [PDF]

Tissue Barriers, 2014
The gastrointestinal mucosa has proven to be an interesting tissue for which to investigate disease-related metabolism. In this review, we outline some evidence that implicates metabolic signaling as important features of barrier in the healthy and disease.
Sean P, Colgan, Valerie F, Curtis, Jordi M, Lanis, Louise E, Glover   +3 more
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Numb mitigates intestinal epithelial cell senescence induced by radiation through a PLK1-dependent pathway

Scientific Reports
Radiation-induced senescence of intestinal epithelial cells plays a crucial role in damaging the intestinal mucosal barrier. Previous studies have implicated Numb in regulating intestinal mucosal barrier homeostasis, while Polo-like kinase 1 (Plk1 ...
Yongtao Yang, Xiao Hu, Yuwei Pan, Wen Ji, Tao Liu, Xi Zheng   +5 more
doaj   +1 more source

When Insult Is Added to Injury: Cross Talk between ILCs and Intestinal Epithelium in IBD

Mediators of Inflammation, 2016
Inflammatory bowel disease (IBD) is characterized by an impairment of the integrity of the mucosal epithelial barrier, which causes exacerbated inflammation of the intestine.
Esmé van der Gracht, Sonja Zahner, Mitchell Kronenberg   +2 more
doaj   +1 more source

Infectious Threats, the Intestinal Barrier, and Its Trojan Horse: Dysbiosis

Frontiers in Microbiology, 2019
The ecosystem of the gut microbiota consists of diverse intestinal species with multiple metabolic and immunologic activities and it is closely connected with the intestinal epithelia and mucosal immune response, with which it builds a complex barrier ...
Simona Iacob, Simona Iacob, Diana Gabriela Iacob   +2 more
doaj   +1 more source