Results 111 to 120 of about 201,161 (293)

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

Long-term in vitro 3D hydrogel co-culture model of inflammatory bowel disease [PDF]

, 2019
The in vitro study of the pathogenesis of inflammatory bowel disease (IBD) requires a cell model which closely reflects the characteristics of the in vivo intestinal epithelium.
Dosh, Rasha H, Jordan-Mahy, Nicola, Le Maitre, Christine L, Sammon, Christopher   +3 more
core   +2 more sources

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Intestinal Epithelial Cell-Specific Deletion of PLD2 Alleviates DSS-Induced Colitis by Regulating Occludin [PDF]

, 2017
Ulcerative colitis is a multi-factorial disease involving a dysregulated immune response. Disruptions to the intestinal epithelial barrier and translocation of bacteria, resulting in inflammation, are common in colitis.
A Sakakibara, B Khor, BC Elias, C Moolenbeek, C Zeiller, CM Costello, CO Elson, CR Weber, E Biganzoli, E Gaudio, G Kale, G Samak, G Zhou, GJ Feldman, GM Jenkins, H Schmitz, HY Lee, J Ghim, J Ghim, JB Park, JD Schulzke, JM Williams, K Brandl, KJ Maloy, KL Edelblum, KR Gardiner, L Wang, LA Dieleman, LW Peterson, M Coeffier, M Coskun, M Natoli, MA Frohman, MA McGuckin, MJ Dorfel, MJ Dorfel, MJ Dorfel, MV Mateos, N Bertiaux-Vandaele, NA Hering, P Farshori, P Munkholm, P Sheth, PM Cummins, Q Wang, R Ahmad, R Al-Sadi, R Mennigen, R Rao, RK Nelson, RK Rao, S Buhner, S Wirtz, S Yamashita, S Zeissig, SC Bischoff, SC Corr, SK Lee, T Chinen, T Sakamoto, T Suzuki, T Tsukamoto, TY Ma, V Wong, WH Ali, X Peng, YC Chae   +66 more
core   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

A Direct Effect of Sex Hormones on Epithelial Barrier Function in Inflammatory Bowel Disease Models

Cells, 2019
Background: Pregnancy is often described as an immune-tolerant state, and a disease modulatory role for pregnancy on inflammatory bowel disease (IBD) has been suggested.
Janine van der Giessen, C. Janneke van der Woude, Maikel P. Peppelenbosch, Gwenny M. Fuhler   +3 more
doaj   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Krill oil, vitamin D and Lactobacillus reuteri cooperate to reduce gut inflammation [PDF]

, 2018
Current research into original therapies to treat intestinal inflammation is focusing on no-drug therapies. KLD is a mixture of krill oil (KO), probiotic Lactobacillus reuteri (LR), and vitamin D (VitD3).
Cesi, V., Colantoni, E., Costanzo, M., Cucchiara, S., Leter, B., Negroni, A., Palone, F., Pierdomenico, M., Stronati, L., Vitali, R.   +9 more
core   +1 more source

Shellac‐Mediated Assembly of Nanoparticles for mRNA Delivery

Advanced Healthcare Materials, EarlyView.
A shellac‐mediated nanoparticle assembly strategy is presented, involving the complexation of mRNA and low‐molecular‐weight cationic molecules (e.g., polyethyleneimine, chitosan, lipids, and poly‐l‐lysine), followed by capping with shellac. This nanoparticle platform enables mRNA transfection following intravenous injection and facilitates gene editing
Meizhang Lu, Jingqu Chen, Zhixing Lin, Wanjun Xu, Tianzheng Wang, Shiyao Li, Die Yang, Frank Caruso   +7 more
wiley   +1 more source

Central role of the gut epithelial barrier in pathogenesis of chronic intestinal inflammation: Lessons learned from animal models and human genetics

Frontiers in Immunology, 2013
The gut mucosa is constantly challenged by a bombardment of foreign antigens and environmental microorganisms. As such, the precise regulation of the intestinal barrier allows the maintenance of mucosal immune homeostasis and prevents the onset of ...
Luca ePastorelli, Luca ePastorelli, Luca ePastorelli, Carlo eDe Salvo, Carlo eDe Salvo, Joseph R. Mercado, Maurizio eVecchi, Maurizio eVecchi, Theresa T. Pizarro   +8 more
doaj   +1 more source