Results 101 to 110 of about 196,268 (297)

Retinoic acid promotes barrier functions in human iPSC-derived intestinal epithelial monolayers

Journal of Pharmacological Sciences, 2019
Vitamin A (VA) is a fat-soluble micronutrient that plays essential roles in various biological processes, including cell growth, differentiation, and apoptosis. In the intestine, VA are known to promote mucosal homeostasis and immunity.
Shigeru Yamada, Yasunari Kanda
doaj   +1 more source

Microenvironmental modulation of the intestinal epithelial barrier [PDF]

, 2022
A healthy gut is essential for human health and healthy aging. Indeed, many diseases are characterized by a disturbed function of the gut, which is often reflected by an abnormal composition of the gut microbiota, e.g., the gut bacteria that help in food digestion and immune regulation.
openaire   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Loss of β-Cytoplasmic Actin in the Intestinal Epithelium Increases Gut Barrier Permeability in vivo and Exaggerates the Severity of Experimental Colitis

Frontiers in Cell and Developmental Biology, 2020
Intestinal epithelial barrier is critical for the maintenance of normal gut homeostasis and disruption of this barrier may trigger or exaggerate mucosal inflammation.
Susana Lechuga, Nayden G. Naydenov, Alex Feygin, Michael Cruise, James M. Ervasti, Andrei I. Ivanov   +5 more
doaj   +1 more source

Role of the protein annexin A1 on the efficacy of anti-TNF treatment in a murine model of acute colitis [PDF]

, 2016
TNF-α is involved in the mechanisms that initiate inflammatory bowel diseases (IBDs). Anti-TNF-α drugs, such as infliximab (IFX), cause non-responsiveness and side effects, indicating the need to investigate alternative therapies for these diseases.
Barrios, Bibiana Elisabet, Correa, Silvia Graciela, De Paula Silva, Marina, Maccio Maretto, Lisa, Oliani, Sonia María, Poliselli Farsky, Sandra Helena, Sena, Angela   +6 more
core   +1 more source

TNF‐α–induced intestinal epithelial cell shedding: implications for intestinal barrier function

Annals of the New York Academy of Sciences, 2012
Although epithelial cells are continuously shed from the surface of the intestine, the intestinal epithelium maintains the integrity of the epithelial barrier. This is achieved through a highly dynamic process involving reorganization of tight junction and adherens junction proteins.
Watson, Alastair J M, Hughes, Kevin R
openaire   +5 more sources

Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders [PDF]

Molecular Autism, 2016
Autism spectrum disorders (ASD) are complex conditions whose pathogenesis may be attributed to gene-environment interactions. There are no definitive mechanisms explaining how environmental triggers can lead to ASD although the involvement of inflammation and immunity has been suggested.
Maria Fiorentino, Anna Sapone, Stefania Senger, Stephanie S. Camhi, Sarah M. Kadzielski, Timothy M. Buie, Deanna L. Kelly, Nicola Cascella, Alessio Fasano   +8 more
openaire   +3 more sources

Spleen‐Targeting Biomimetic Hybrid Nanocarriers for Systemic Immune Reprogramming in Colitis: RBC Membrane Vesicle‐Fused Lipid Nanoparticles

Advanced Functional Materials, EarlyView.
A spleen‐targeting hybrid nanoplatform (RBCMV‐LNP‐RP) harnessing erythrophagocytosis mimics senescent red blood cell clearance to achieve spleen‐specific delivery of rapamycin. This biomimetic system enables selective accumulation in splenic macrophages, orchestrating systemic immune reprogramming and promoting mucosal healing in an inflammatory bowel ...
Jun Kwon, Hee Su Sohn, Jong Sang Yoon, So Won Jeon, Hee Gyeong Ko, Min‐Ho Kang, Jisun Lee, Jae‐Hwan Nam, Louis T. Merriam, Edy Y. Kim, Han Young Kim   +10 more
wiley   +1 more source

GZMA suppressed GPX4-mediated ferroptosis to improve intestinal mucosal barrier function in inflammatory bowel disease

Cell Communication and Signaling
Background Our previous study has demonstrated a decreased colonic CD8+CD39+ T cells, enrichment of granzyme A (GZMA), was found in pediatric-onset colitis and inflammatory bowel disease (IBD) characterized by impaired intestinal barrier function ...
Rongwei Niu, Jiaoli Lan, Danxia Liang, Li Xiang, Jiaxin Wu, Xiaoyan Zhang, Zhiling Li, Huan Chen, Lanlan Geng, Wanfu Xu, Sitang Gong, Min Yang   +11 more
doaj   +1 more source

Wall of Resilience: How the Intestinal Epithelium Prevents Inflammatory Onslaught in the GutSummary

Cellular and Molecular Gastroenterology and Hepatology
The intestinal epithelium forms the boundary between the intestinal immune system in the lamina propria and the outside world, the intestinal lumen, which contains a diverse array of microbial and environmental antigens.
Eva Liebing, Susanne M. Krug, Markus F. Neurath, Britta Siegmund, Christoph Becker   +4 more
doaj   +1 more source