Results 41 to 50 of about 196,268 (297)

IL-1β and the Intestinal Epithelial Tight Junction Barrier [PDF]

Frontiers in Immunology, 2021
The intestinal epithelial tight junction (TJ) barrier controls the paracellular permeation of contents from the intestinal lumen into the intestinal tissue and systemic circulation. A defective intestinal TJ barrier has been implicated as an important pathogenic factor in inflammatory diseases of the gut including Crohn’s disease, ulcerative colitis ...
Lauren W. Kaminsky, Rana Al-Sadi, Thomas Y. Ma   +2 more
openaire   +3 more sources

Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation [PDF]

, 2016
Although defects in intestinal barrier function are discussed as a key pathogenic factor in patients with inflammatory bowel diseases (IBD), the molecular pathways driving disease-specific alterations of intestinal epithelial cells (IECs) are largely ...
Alastair J.M. Watson, Arif B. Ekici, Becker, Christoph Becker, Claudia Günther, Cord Brakebusch, Distler, Gionata Fiorino, Heller, Hopkins, Imke Atreya, Kerstin Amann, Lin, Markus F. Neurath, Martin Bergö, Ohkusa, Pastorelli, Pechlivanis, Raja Atreya, Rocío López-Posadas, Silvio Danese, Stefan Tenzer, Stefan Wirtz, Stefania Vetrano, Turcotte, Ulrike Billmeier, Veronika Thonn, Zverina   +27 more
core   +1 more source

Age-Associated Remodeling of the Intestinal Epithelial Barrier [PDF]

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2013
Disorders of the gastrointestinal tract are common in the elderly people; however, the precise trait(s) of aging that contribute to the vulnerability of the gastrointestinal tract are poorly understood. Recent evidence suggests that patients with gastrointestinal disorders have increased intestinal permeability.
Lee, Tran, Beverley, Greenwood-Van Meerveld   +1 more
openaire   +2 more sources

Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function [PDF]

World Journal of Gastroenterology, 2007
To test the hypothesis that hydrolysis of sphingomyelin to ceramide changes the composition of tight junctions (TJs) with increasing permeability of the intestinal epithelium.Monolayers of Caco-2 cells were used as an in vitro model for the intestinal barrier.
Jurgen, Bock, Gerhard, Liebisch, Joachim, Schweimer, Gerd, Schmitz, Gerhard, Rogler   +4 more
openaire   +2 more sources

Metabolic regulation of intestinal epithelial barrier during inflammation [PDF]

Tissue Barriers, 2014
The gastrointestinal mucosa has proven to be an interesting tissue for which to investigate disease-related metabolism. In this review, we outline some evidence that implicates metabolic signaling as important features of barrier in the healthy and disease.
Sean P, Colgan, Valerie F, Curtis, Jordi M, Lanis, Louise E, Glover   +3 more
openaire   +2 more sources

Intestinal Epithelial Cell-Specific Deletion of PLD2 Alleviates DSS-Induced Colitis by Regulating Occludin [PDF]

, 2017
Ulcerative colitis is a multi-factorial disease involving a dysregulated immune response. Disruptions to the intestinal epithelial barrier and translocation of bacteria, resulting in inflammation, are common in colitis.
A Sakakibara, B Khor, BC Elias, C Moolenbeek, C Zeiller, CM Costello, CO Elson, CR Weber, E Biganzoli, E Gaudio, G Kale, G Samak, G Zhou, GJ Feldman, GM Jenkins, H Schmitz, HY Lee, J Ghim, J Ghim, JB Park, JD Schulzke, JM Williams, K Brandl, KJ Maloy, KL Edelblum, KR Gardiner, L Wang, LA Dieleman, LW Peterson, M Coeffier, M Coskun, M Natoli, MA Frohman, MA McGuckin, MJ Dorfel, MJ Dorfel, MJ Dorfel, MV Mateos, N Bertiaux-Vandaele, NA Hering, P Farshori, P Munkholm, P Sheth, PM Cummins, Q Wang, R Ahmad, R Al-Sadi, R Mennigen, R Rao, RK Nelson, RK Rao, S Buhner, S Wirtz, S Yamashita, S Zeissig, SC Bischoff, SC Corr, SK Lee, T Chinen, T Sakamoto, T Suzuki, T Tsukamoto, TY Ma, V Wong, WH Ali, X Peng, YC Chae   +66 more
core   +1 more source

Sinapic Acid Alleviated Inflammation-Induced Intestinal Epithelial Barrier Dysfunction in Lipopolysaccharide- (LPS-) Treated Caco-2 Cells

Mediators of Inflammation, 2021
The integrity and permeability of the intestinal epithelial barrier are important indicators of intestinal health. Impaired intestinal epithelial barrier function and increased intestinal permeability are closely linked to the onset and progression of ...
Huan Lan, Lu-Ying Zhang, Wen He, Wan-Ying Li, Zhen Zeng, Bo Qian, Chengqiang Wang, Jia-Le Song   +7 more
doaj   +1 more source

Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5Summary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Epithelial cells form a monolayer at mucosal surface that functions as a highly selective barrier. Lysophosphatidic acid (LPA) is a bioactive lipid that elicits a broad range of biological effects via cognate G protein-coupled ...
Mo Wang, Peijian He, Yiran Han, Lei Dong, C. Chris Yun   +4 more
doaj   +1 more source

Histopathology of the gut in rheumatic diseases [PDF]

, 2018
The gastrointestinal tract regulates the trafficking of macromolecules between the environment and the host through an epithelial barrier mechanism and is an important part of the immune system controlling the equilibrium between tolerance and immunity ...
Ciccia F., Ferrante A., Guggino G., Macaluso F., Rizzo A.   +4 more
core   +1 more source

Caspase-8 controls the gut response to microbial challenges by Tnf-alpha-dependent and independent pathways [PDF]

, 2014
Objectives: Intestinal epithelial cells (IEC) express toll-like receptors (TLR) that facilitate microbial recognition. Stimulation of TLR ligands induces a transient increase in epithelial cell shedding, a mechanism that serves the antibacterial and ...
Basic, Marijana, Becker, Christoph, Bleich, André, Buchen, Barbara, Gunther, Claudia, He, Gui-Wei, Hornef, Mathias, Martini, Eva, Neumann, Helmut, Neurath, Markus F., Torow, Natalia, Watson, Alastair J. M., Wittkopf, Nadine   +12 more
core   +3 more sources