Results 41 to 50 of about 196,559 (297)

Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function [PDF]

World Journal of Gastroenterology, 2007
To test the hypothesis that hydrolysis of sphingomyelin to ceramide changes the composition of tight junctions (TJs) with increasing permeability of the intestinal epithelium.Monolayers of Caco-2 cells were used as an in vitro model for the intestinal barrier.
Jurgen, Bock, Gerhard, Liebisch, Joachim, Schweimer, Gerd, Schmitz, Gerhard, Rogler   +4 more
openaire   +2 more sources

Metabolic regulation of intestinal epithelial barrier during inflammation [PDF]

Tissue Barriers, 2014
The gastrointestinal mucosa has proven to be an interesting tissue for which to investigate disease-related metabolism. In this review, we outline some evidence that implicates metabolic signaling as important features of barrier in the healthy and disease.
Sean P, Colgan, Valerie F, Curtis, Jordi M, Lanis, Louise E, Glover   +3 more
openaire   +2 more sources

Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5Summary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Epithelial cells form a monolayer at mucosal surface that functions as a highly selective barrier. Lysophosphatidic acid (LPA) is a bioactive lipid that elicits a broad range of biological effects via cognate G protein-coupled ...
Mo Wang, Peijian He, Yiran Han, Lei Dong, C. Chris Yun   +4 more
doaj   +1 more source

Intestinal Epithelial Cell-Specific Deletion of PLD2 Alleviates DSS-Induced Colitis by Regulating Occludin [PDF]

, 2017
Ulcerative colitis is a multi-factorial disease involving a dysregulated immune response. Disruptions to the intestinal epithelial barrier and translocation of bacteria, resulting in inflammation, are common in colitis.
A Sakakibara, B Khor, BC Elias, C Moolenbeek, C Zeiller, CM Costello, CO Elson, CR Weber, E Biganzoli, E Gaudio, G Kale, G Samak, G Zhou, GJ Feldman, GM Jenkins, H Schmitz, HY Lee, J Ghim, J Ghim, JB Park, JD Schulzke, JM Williams, K Brandl, KJ Maloy, KL Edelblum, KR Gardiner, L Wang, LA Dieleman, LW Peterson, M Coeffier, M Coskun, M Natoli, MA Frohman, MA McGuckin, MJ Dorfel, MJ Dorfel, MJ Dorfel, MV Mateos, N Bertiaux-Vandaele, NA Hering, P Farshori, P Munkholm, P Sheth, PM Cummins, Q Wang, R Ahmad, R Al-Sadi, R Mennigen, R Rao, RK Nelson, RK Rao, S Buhner, S Wirtz, S Yamashita, S Zeissig, SC Bischoff, SC Corr, SK Lee, T Chinen, T Sakamoto, T Suzuki, T Tsukamoto, TY Ma, V Wong, WH Ali, X Peng, YC Chae   +66 more
core   +1 more source

Sinapic Acid Alleviated Inflammation-Induced Intestinal Epithelial Barrier Dysfunction in Lipopolysaccharide- (LPS-) Treated Caco-2 Cells

Mediators of Inflammation, 2021
The integrity and permeability of the intestinal epithelial barrier are important indicators of intestinal health. Impaired intestinal epithelial barrier function and increased intestinal permeability are closely linked to the onset and progression of ...
Huan Lan, Lu-Ying Zhang, Wen He, Wan-Ying Li, Zhen Zeng, Bo Qian, Chengqiang Wang, Jia-Le Song   +7 more
doaj   +1 more source

A fixed combination of probiotics and herbal extracts attenuates intestinal barrier dysfunction from inflammatory stress in an in vitro model using Caco-2 cells. [PDF]

, 2019
Background: Inflammatory Bowel Diseases (IBD), are considered a growing global disease, with about ten million people being affected worldwide. Maintenance of intestinal barrier integrity is crucial for preventing IBD onset and exacerbations. Some recent
Biagi, M, Borgonetti, V, Carnevali, I, Catanzaro, D, Cocetta, V, Giron, MC, Governa, P, Montopoli, M, Ragazzi, E   +8 more
core   +1 more source

A Multi-Strain Probiotic Formulation Improves Intestinal Barrier Function by the Modulation of Tight and Adherent Junction Proteins

Cells, 2022
In healthy individuals, tight junction proteins (TJPs) maintain the integrity of the intestinal barrier. Dysbiosis and increased intestinal permeability are observed in several diseases, such as inflammatory bowel disease. Many studies highlight the role
Raffaella di Vito, Carmela Conte, Giovanna Traina   +2 more
doaj   +1 more source

Histopathology of the gut in rheumatic diseases [PDF]

, 2018
The gastrointestinal tract regulates the trafficking of macromolecules between the environment and the host through an epithelial barrier mechanism and is an important part of the immune system controlling the equilibrium between tolerance and immunity ...
Ciccia F., Ferrante A., Guggino G., Macaluso F., Rizzo A.   +4 more
core   +1 more source

Caspase-8 controls the gut response to microbial challenges by Tnf-alpha-dependent and independent pathways [PDF]

, 2014
Objectives: Intestinal epithelial cells (IEC) express toll-like receptors (TLR) that facilitate microbial recognition. Stimulation of TLR ligands induces a transient increase in epithelial cell shedding, a mechanism that serves the antibacterial and ...
Basic, Marijana, Becker, Christoph, Bleich, André, Buchen, Barbara, Gunther, Claudia, He, Gui-Wei, Hornef, Mathias, Martini, Eva, Neumann, Helmut, Neurath, Markus F., Torow, Natalia, Watson, Alastair J. M., Wittkopf, Nadine   +12 more
core   +3 more sources

Intestinal epithelial barrier: The target for pathogenic Escherichia coli [PDF]

Advances in Clinical and Experimental Medicine, 2017
Diarrheagenic Escherichia coli strains are included in 9 pathotypes (pathovars) that present different virulence factors responsible for the patomechanism of infections they cause. As all other intestinal pathogens, E. coli exerts a significant effect on intestinal epithelium.
Barbara, Pawłowska, Beata M, Sobieszczańska   +1 more
openaire   +2 more sources