Results 91 to 100 of about 437,417 (289)

Pravastatin Attenuates Acute Radiation-Induced Enteropathy and Improves Epithelial Cell Function

Frontiers in Pharmacology, 2018
Background and Aim: Radiation-induced enteropathy is frequently observed after radiation therapy for abdominal and pelvic cancer or occurs secondary to accidental radiation exposure.
Hyosun Jang, Janet Lee, Sunhoo Park, Sunhoo Park, Hyunwook Myung, Jihoon Kang, Kyuchang Kim, Hyewon Kim, Won-Suk Jang, Sun-Joo Lee, Sehwan Shim, Jae K. Myung, Jae K. Myung   +12 more
doaj   +1 more source

Krüppel-like factor 4 regulates intestinal epithelial cell morphology and polarity. [PDF]

PLoS ONE, 2012
Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor that plays a vital role in regulating cell lineage differentiation during development and maintaining epithelial homeostasis in the intestine.
Tianxin Yu, Xi Chen, Wen Zhang, Juan Li, Ren Xu, Timothy C Wang, Walden Ai, Chunming Liu   +7 more
doaj   +1 more source

Epithelial cell specific Raptor is required for initiation of type 2 mucosal immunity in small intestine [PDF]

, 2017
Intestinal tuft cells are one of 4 secretory cell linages in the small intestine and the source of IL-25, a critical initiator of the type 2 immune response to parasite infection. When Raptor, a critical scaffold protein for mammalian target of rapamycin
Aladegbami, Bola, Bao, James, Barron, Lauren, Colasanti, Jason, Erwin, Christopher R, Guo, Jun, Warner, Brad W   +6 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Advances in intestinal epithelium and gut microbiota interaction

Frontiers in Microbiology
The intestinal epithelium represents a critical interface between the host and external environment, serving as the second largest surface area in the human body after the lungs.
Sen Yang, Sen Yang, Hanmin Liu, Hanmin Liu, Hanmin Liu, Hanmin Liu, Yang Liu, Yang Liu, Yang Liu, Yang Liu   +9 more
doaj   +1 more source

Curcumin Mitigates Immune-Induced Epithelial Barrier Dysfunction by Campylobacter jejuni [PDF]

, 2019
Campylobacter jejuni (C. jejuni) is the most common cause of foodborne gastroenteritis worldwide. The bacteria induce diarrhea and inflammation by invading the intestinal epithelium. Curcumin is a natural polyphenol from turmeric rhizome of Curcuma longa,
Bereswill, Stefan, Butkevych, Eduard, Bücker, Roland, Fromm, Anja, Golz, Julia C., Heimesaat, Markus M., Kehrenberg, Corinna, Kittler, Sophie, Lobo de Sá, Fábia Daniela, Moos, Verena, Mousavi, Soraya, Nattramilarasu, Praveen Kumar, Schulzke, Jörg-Dieter, Seinige, Diana, Stingl, Kerstin   +14 more
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. [PDF]

, 2018
Epithelial dysfunction and crypt destruction are defining features of inflammatory bowel disease (IBD). However, current IBD therapies targeting epithelial dysfunction are lacking.
Bayrer, James R, Escusa, Hazel S, Fletterick, Robert J, Ingraham, Holly A, Klein, Ophir D, Moore, David D, Nattiv, Roy, Suzawa, Miyuki, Wang, Hongtao   +8 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source