Results 271 to 280 of about 437,417 (289)

Primary Mouse Small Intestinal Epithelial Cell Cultures

2012
The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. We have recently shown that Lgr5 (Leucine-rich repeat-containing G protein-coupled receptor) is expressed in intestinal stem cells by an in vivo genetic lineage tracing strategy.
Sato, T., Clevers, H.
openaire   +3 more sources

The intestinal epithelial cell cycle

Current Opinion in Gastroenterology, 2015
To discuss the recent landmark findings that have increased our understanding not only of the role of the epithelial cell cycle in the homeostasis of the small intestine, but also its relevance to inflammation and cancer.Recent data have unveiled novel information on protein interactions directly involved in the cell cycle as well as in the pathways ...
Declan P, McKernan, Laurence J, Egan
openaire   +2 more sources

Epithelial Cell Contributions to Intestinal Immunity

2015
The epithelial surfaces of the mammalian intestine interface directly with the external environment and thus continuously encounter pathogenic bacteria, fungi, viruses, and parasites. The intestinal epithelium is also closely associated with complex communities of symbiotic microorganisms.
openaire   +2 more sources

Cell death of intestinal epithelial cells in intestinal diseases.

Sheng li xue bao : [Acta physiologica Sinica], 2020
Gut injury continues to be the devastating and unpredictable critical illness associated with increased cell death of intestinal epithelial cells (IECs). The IECs, immune system and microbiome are the interrelated entities to maintain normal intestinal homeostasis and barrier integrity.
Saravanan, Subramanian, Hua, Geng, Xiao-Di, Tan   +2 more
openaire   +1 more source

Intestinal Epithelial Cell Regulation of Mucosal Inflammation

Immunologic Research, 2004
The intestinal epithelium serves as one of human's primary interfaces with the outside world. This interface is very heavily colonized with bacteria and yet permits absorption of life-sustaining nutrients while protecting the tissues below from microbial onslaught.
Yimin, Yu, Shanthi, Sitaraman, Andrew T, Gewirtz   +2 more
openaire   +2 more sources

Intestinal epithelial cells secrete exosome–like vesicles

Gastroenterology, 2001
Given the observations that intestinal epithelial cells (IECs) can present antigens to CD4(+) T lymphocytes and that professional antigen-presenting cells secrete exosomes (antigen-presenting vesicles), we hypothesized that IECs may secrete exosomes carrying molecules implicated in antigen presentation, which may be able to cross the basement membrane ...
G, van Niel, G, Raposo, C, Candalh, M, Boussac, R, Hershberg, N, Cerf-Bensussan, M, Heyman   +6 more
openaire   +2 more sources

Neutrophil-Epithelial Cell Interactions in the Intestine

1991
PMN transmigration across intestinal epithelia and into crypt lumens is a hallmark of active intestinal disease. Models of the transmigratory event indicate that movement of PMN across intercellular tight junctions transiently increases junctional permeability, thus decreasing epithelial barrier function.
J L, Madara, S, Nash, C, Parkos
openaire   +2 more sources

Solute Transport Process in Intestinal Epithelial Cells

Membrane Biochemistry, 1979
In rat small intestine, the active transport of organic solutes results in significant depolarization of the membrane potential measured in an epithelial cell with respect to a grounded mucosal solution and in an increase in the transepithelial potential difference.
openaire   +2 more sources

Epithelial Stem Cells and Tissue Engineered Intestine

Current Stem Cell Research & Therapy, 2006
The intestinal mucosa has an amazing regenerative capacity, enabling rapid restoration of its physiological functions following injury. The ability to do this resides with the epithelial stem cells located within glandular invaginations in the mucosal surface.
openaire   +2 more sources

Intestinal epithelial cells in health and disease

Tissue Barriers
This comprehensive review delves into the pivotal role of intestinal epithelial cells in the context of various diseases. It provides an in-depth analysis of the diverse types and functions of these cells, explores the influence of multiple signaling pathways on their differentiation, and elucidates their critical roles in a spectrum of diseases.
Chenchen, An, Chonggui, Jiang, Wangxiang, Pei, Ao, Li, Minghui, Wang, Yufei, Wang, Hua, Wang, Li, Zuo   +7 more
openaire   +2 more sources