Results 51 to 60 of about 437,417 (289)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

MicroRNAs determine human intestinal epithelial cell fate [PDF]

Differentiation, 2010
MicroRNAs (miRNAs) are small, non-coding RNA molecules that post-transcriptionally regulate gene expression. Evidence has shown that miRNAs play important roles in various cellular processes, including proliferation, differentiation and survival. The intestinal epithelium is regenerated throughout life, and enterocytes undergo differentiation during ...
Dalmasso, Guillaume, Thu Nguyen, Hang, Yan, Yutao, Laroui, Hamed, Srinivasan, Shanthi, Sitaraman, Shanthi, Merlin, Didier   +6 more
openaire   +3 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Irisin promotes intestinal epithelial cell proliferation via Wnt/β-catenin and focal adhesion kinase signaling pathways

Scientific Reports
The regeneration of epithelia is crucial for maintaining intestinal homeostasis. Irisin is an exercise-induced hormone originally found to be secreted by skeletal muscles, thereby regulating energy metabolism.
Arong Gaowa, Supasuta Leangpanich, Eun Jeong Park, Eiji Kawamoto, Motomu Shimaoka   +4 more
doaj   +1 more source

Inhibitory Effect and Mechanism of Lactobacillus reuteri on Inflammation and Apoptosis of Intestinal Epithelial Cells [PDF]

Shipin Kexue
Objective: To investigate the effect and mechanism of Lactobacillus reuteri on the inflammatory response and apoptosis of intestinal epithelial cells.
CHEN Peng, ZHONG Yuna, YU Liwen, HU Jin, XIE Meiying
doaj   +1 more source

Applying the adverse outcome pathway (AOP) for food sensitization to support in vitro testing strategies [PDF]

, 2019
Background Before introducing proteins from new or alternative dietary sources into the market, a compressive risk assessment including food allergic sensitization should be carried out in order to ensure their safety.
Benedé, Sara, Bouchaud, Grégory, Costa, Ana, Denery-Papini, Sandra, Díaz-Perales, Araceli, E.M. Willemsen, Linette, Garrido-Arandia, María, Gavrovic-Jankulovic, Marija, H.M. van Bilsen, Jolanda, Hayen, Simone, L. Bavaro, Simona, L. Roggen, Erwin, Lozano-Ojalvo, Daniel, M. Antunes, Célia, Wróblewska, Mónica   +14 more
core   +1 more source

KLF4 regulation in intestinal epithelial cell maturation [PDF]

Experimental Cell Research, 2008
The Krüppel-like factor 4 (KLF4) transcription factor suppresses tumorigenesis in gastrointestinal epithelium. Thus, its expression is decreased in gastric and colon cancers. Moreover, KLF4 regulates both differentiation and growth that is likely fundamental to its tumor suppressor activity.
Flandez, M., Guilmeau, Sandra, Blache, P., Augenlicht, L.H.   +3 more
openaire   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche. [PDF]

, 2018
Epithelial surfaces form critical barriers to the outside world and are continuously renewed by adult stem cells1. Whereas dynamics of epithelial stem cells during homeostasis are increasingly well understood, how stem cells are redirected from a tissue ...
de Sauvage, Frederic J, Klein, Ophir D, Landman, Tyler A, Locksley, Richard M, Marangoni, Pauline, Nusse, Ysbrand M, Rosendahl-Huber, Axel KM, Savage, Adam K   +7 more
core  

To respond or not to respond - a personal perspective of intestinal tolerance [PDF]

, 2018
For many years, the intestine was one of the poor relations of the immunology world, being a realm inhabited mostly by specialists and those interested in unusual phenomena.
A Besredka, A Goubier, A Iwasaki, A Konrad, A Limmer, A Mortha, A Vaillant, AJ MacPherson, Allan McI. Mowat, AM Mowat, B Cassani, B Dubois, B Jabri, B Johansson-Lindbom, C Asseman, C Berlin, C Siewert, C Varol, CC Bain, CC Bain, CL Scott, CL Scott, CM Sun, CR Mackay, CR Stokes, D Esterhazy, D Fina, D Mucida, D Sichien, DP McGovern, DS Shouval, E Jaensson, E Jaensson-Gyllenback, E Mazzini, E Zigmond, EJ Kunkel, EM Nilsen, EM Nilsen, F Broere, F Ginhoux, F Hauet-Broere, F Powrie, FG Chirdo, G Lack, G Matteoli, G Mayrhofer, G Monteleone, GG MacPherson, H Arentz-Hanson, H Fukaura, H Tlaskalova, HG Wells, HL Klaasen, HL Weiner, HL Weiner, I Vicente-Suarez, ID Iliev, II Ivanov, J Farache, J Farache, JA Mattingly, JA Mattingly, JB Sun, JF Heremans, JH Niess, JL Coombes, JL Gowans, JL Viney, JM Blander, JP Hugot, JR Battisto, JR McDole, K Atarashi, K Atarashi, K Lahl, K Nagatani, K Takeda, KG McDonald, KM Luda, KM Smith, KP Zimmer, KS Kim, L Maiuri, L Maiuri, L Saurer, LA Hanson, LA Reynolds, LA Waaij van der, LM Sollid, M Boucard-Jourdin, M Butler, M Chieppa, M Karlsson, M Murai, M Rescigno, M Rimoldi, M Tsuji, M Yoshida, MH Jang, MH Jang, MO Li, MR Hepworth, MR Karlsson, MW Chase, N Korneychuk, N Satoh-Takayama, N Sudo, O Schulz, P Brandtzaeg, P Morrissey, PA Crabbe, PB Carter, PM Smith, R Bouziat, R Kuhn, R Zeng, R Zeng, RE Araya, RL Owen, RW DePaolo, S Hue, S Husby, S Husby, S Kawamoto, S Strobel, S Strobel, S Veenbergen, S Wilks, SI Hammerschmidt, SK Mazmanian, SV Kim, T Joeris, T Worbs, TB Tomasi Jr, TL Denning, U Hadis, V Cerovic, V Gaboriau-Routhiau, Y Chen, Y Cong, Y Ogura, ZM Falchuk, Ø Molberg   +142 more
core   +1 more source