Results 71 to 80 of about 437,417 (289)
Intestinal epithelial responses to Salmonella enterica serovar Enteritidis: Effects on intestinal permeability and ion transport [PDF]
, 2019 Salmonella infection of chickens that leads to potential human foodborne salmonellosis continues to be a major concern. Chickens serve as carriers but, in contrast to humans, rarely show any clinical signs including diarrhea.
Aschenbach, J. R. +4 more
core +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Isolation and 3-dimensional Culture of Primary Murine Intestinal Epithelial Cells
Bio-Protocol, 2014 The intestine, together with skin and blood, belongs to the organs with the highest cell turnover, which makes it a perfect model to study cellular processes, such as proliferation and differentiation.
Agnieszka Pastula, Michael Quante
doaj +1 more source
Celiac Disease Monocytes Induce a Barrier Defect in Intestinal Epithelial Cells [PDF]
, 2019 Intestinal epithelial barrier function in celiac disease (CeD) patients is altered. However, the mechanism underlying this effect is not fully understood.
Branchi, Federica +6 more
core +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2016 Background/Aims: Understanding the mechanism that involves in regulating epithelial cells renewal is the fundamental of regulating intestinal mucosa development and functions and related diseases.
Huansheng Yang +3 more
doaj +1 more source
PLoS Pathogens, 2021 The gastrointestinal epithelium guides the immune system to differentiate between commensal and pathogenic microbiota, which relies on intimate links with the type I IFN signal pathway. Epithelial cells along the epithelium provide the front line of host
Juan Li +9 more
doaj +1 more source
The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression [PDF]
, 2009 The gastrointestinal tract represents the first barrier against food contaminants as well as the first target for these toxicants. Deoxynivalenol (DON) is a mycotoxin that commonly contaminates cereals and causes various toxicological effects.
Bracarense, Ana-Paula +8 more
core +2 more sources
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Loss of Sonic hedgehog leads to alterations in intestinal secretory cell maturation and autophagy. [PDF]
PLoS ONE, 2014 Intestinal epithelial cells express the Sonic and Indian hedgehog ligands. Despite the strong interest in gut hedgehog signaling in GI diseases, no studies have specifically addressed the singular role of intestinal epithelial cell Sonic hedgehog ...
Jessica Gagné-Sansfaçon +4 more
doaj +1 more source