Spatial transcriptome analysis of myenteric plexus and intestinal epithelium of colon in patients with Parkinson’s disease [PDF]
Acta Neuropathologica CommunicationsAlpha-synuclein (AS) accumulation is found in the nerve plexuses of the gastrointestinal tract in patients with Parknison’s disease (PD). Moreover, alterations in microbiome composition and its metabolites were confirmed in the colon of patients with PD.
Chaewon Shin +8 more
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PRMT5 Maintains Homeostasis of the Intestinal Epithelium by Modulating Cell Proliferation and Survival [PDF]
Advanced ScienceIntestinal homeostasis is sustained by self‐renewal of intestinal stem cells, which continuously divide and produce proliferative transit‐amplifying (TA) and progenitor cells.
Leilei Li +7 more
doaj +2 more sources
Tuft cells promote human intestinal epithelium regeneration as reserve stem cells after irradiation [PDF]
Cell RegenerationIntestinal epithelium regeneration is crucial for homeostatic maintenance of the intestinal functions. A recent study published in Nature uncovers tuft cells as an unexpected key player in the regenerative process.
Yehua Li +3 more
doaj +2 more sources
Development of Functional Microfold (M) Cells from Intestinal Stem Cells in Primary Human Enteroids. [PDF]
, 2016 Background & aimsIntestinal microfold (M) cells are specialized epithelial cells that act as gatekeepers of luminal antigens in the intestinal tract.
Dunn, James CY +11 more
core +12 more sources
Tuft cells: sentinels of the intestinal mucosa
Comptes Rendus Biologies, 2021 The intestinal epithelium is one of our main interfaces with the outside world, including the intestinal microbiota. This epithelium thus combines the two essential functions of nutrient absorption and barrier.
Jay, Philippe
doaj +1 more source
Intestinal subepithelial myofibroblasts support in vitro and in vivo growth of human small intestinal epithelium. [PDF]
PLoS ONE, 2011 The intestinal crypt-niche interaction is thought to be essential to the function, maintenance, and proliferation of progenitor stem cells found at the bases of intestinal crypts.
Nicholas Lahar +9 more
doaj +1 more source
Intestinal cellular heterogeneity and disease development revealed by single-cell technology
Cell Regeneration, 2022 The intestinal epithelium is responsible for food digestion and nutrient absorption and plays a critical role in hormone secretion, microorganism defense, and immune response.
Yalong Wang +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 This study aimed to determine whether Bmi-1 deficiency leads to intestinal epithelial barrier destruction and microbiota dysfunction, which members of the microbial community alter barrier function with age, and whether p16INK4a deletion could reverse ...
Jiawen Zhou +14 more
doaj +1 more source
Effects of six common dietary nutrients on murine intestinal organoid growth. [PDF]
PLoS ONE, 2018 The intestinal epithelium of the gastrointestinal (GI) tract constantly renews itself to absorb nutrients and provide protection for the body from the outside world.
Tenson Cai +5 more
doaj +1 more source
iScience, 2021 Summary: Homeostasis in the intestinal epithelium is maintained by Lgr5-positive intestinal stem cells (ISCs) located at the base of the crypt. The function of ISCs is reduced upon aging which leads to a decline of regeneration of the intestinal ...
Kodandaramireddy Nalapareddy +4 more
doaj +1 more source