Results 21 to 30 of about 669,928 (206)

LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium [PDF]

, 2020
Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period.
Zwiggelaar, R.T., Kvaløy, E., Drabløs, F., Oudhoff, Menno J., Ohta, Yuki, Jensen, Kim B., Zwiggelaar, Rosalie, Díez-Sánchez, A., Lindholm, Håvard T., Lindholm, H.T., Rye, M., Martín-Alonso, Mara, Zwiggelaar, Rosalie T., Drabløs, Finn, Terndrup Pedersen, Marianne, Arrowsmith, Cheryl H, Kvaløy, Emilie, Spanjers, Roos R., Arrowsmith, C., Fosslie, Madeleine, Dahl, John Arne, Díez-Sánchez, Alberto, Oudhoff, Menno, Rye, Morten Beck, Matano, M., Matano, Mami, Spanjers, R.R., Dahl, J.A., Arrowsmith, Cheryl, Nazmi, Kamran, Fosslie, Madeleine Lystad, Rye, Morten, Sato, T., Martín-Alonso, M., Oudhoff, M.J., Nazmi, K., Pedersen, Marianne Terndrup, Sato, Toshiro, Pedersen, M.T., Parmar, N., Arne Dahl, John, Fosslie, M., Ostrop, J., Ohta, Y., Matono, Mami, Spanjers, Roos, Jensen, K.B., Ostrop, Jenny, Lindholm, Håvard Takle, Parmar, Naveen   +49 more
core   +1 more source

Glucose sensing in the intestinal epithelium [PDF]

European Journal of Biochemistry, 2003
Dietary sugars regulate expression of the intestinal Na+/glucose cotransporter, SGLT1, in many species. Using sheep intestine as a model, we showed that lumenal monosaccharides, both metabolisable and nonmetabolisable, regulate SGLT1 expression. This regulation occurs not only at the level of transcription, but also at the post‐transcriptional level ...
Jane, Dyer, Steven, Vayro, Timothy P, King, Soraya P, Shirazi-Beechey   +3 more
openaire   +2 more sources

A key role for E-cadherin in intestinal homeostasis and Paneth cell maturation. [PDF]

, 2010
E-cadherin is a major component of adherens junctions. Impaired expression of E-cadherin in the small intestine and colon has been linked to a disturbed intestinal homeostasis and barrier function.
Trülzsch, Konrad, Eckhard Wolf, Sylvia Steininger, Hirschi Benjamin, Müller-Höcker Josef, Frank T Kolligs, Allgäuer, Michael, Marlon R. Schneider, Schneider Marlon R., Dahlhoff, Maik, Gerhard Markus, Schneider, Marlon R., Konrad Trülzsch, Vogelmann, Roger, Maik Dahlhoff, Müller-Höcker, Josef, Michael Allgäuer, Allgäuer Michael, Horst David, Roger Vogelmann, Markus Gerhard, Horst, David, Frank T. Kolligs, Wolf Eckhard, Dahlhoff Maik, Benjamin Hirschi, Kolligs, Frank T., David Horst, Trülzsch Konrad, Wolf, Eckhard, Josef Müller-Höcker, Kolligs Frank T., Marlon R Schneider, Hirschi, Benjamin, Steininger Sylvia, Gerhard, Markus, Steininger, Sylvia, Vogelmann Roger, Schneider, MR;Dahlhoff, M;Horst, D;Hirschi, B;Trülzsch, K;Müller-Höcker, J;Vogelmann, R;Allgauer, M;Gerhard, M;Steininger, S;Wolf, E;Kolligs, FT   +38 more
core   +1 more source

Mend Your FencesSummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
The intestinal epithelium can be easily disrupted during gut inflammation as seen in inflammatory bowel disease (IBD), such as ulcerative colitis or Crohn’s disease.
Eva Martini, Susanne M. Krug, Britta Siegmund, Markus F. Neurath, Christoph Becker   +4 more
doaj   +1 more source

Barrett’s Esophagus and Intestinal Metaplasia

Frontiers in Oncology, 2021
Intestinal metaplasia refers to the replacement of the differentiated and mature normal mucosal epithelium outside the intestinal tract by the intestinal epithelium.
Lu Zhang, Binyu Sun, Xi Zhou, QiongQiong Wei, Sicheng Liang, Gang Luo, Tao Li, Muhan Lü   +7 more
doaj   +1 more source

Always one step ahead: How pathogenic bacteria use the type III secretion system to manipulate the intestinal mucosal immune system [PDF]

, 2011
The intestinal immune system and the epithelium are the first line of defense in the gut. Constantly exposed to microorganisms from the environment, the gut has complex defense mechanisms to prevent infections, as well as regulatory pathways to tolerate ...
Anna Vossenkämper, Thomas T MacDonald, Marches, O, Vossenkamper, A, Olivier Marchès, MacDonald, TT   +5 more
core   +1 more source

Intestinal epithelial plasticity and regeneration via cell dedifferentiation

Cell Regeneration, 2020
The intestinal epithelium possesses a great capacity of self-renewal under normal homeostatic conditions and of regeneration upon damages. The renewal and regenerative processes are driven by intestinal stem cells (ISCs), which reside at the base of ...
Yuan Liu, Ye-Guang Chen
doaj   +1 more source

PLK1 protects intestinal barrier function during sepsis by targeting mitochondrial dynamics through TANK-NF-κB signalling

Molecular Medicine, 2022
Background Intestinal barrier integrity in the pathogenesis of sepsis is critical. Despite an abundance of evidence, the molecular mechanism of the intestinal barrier in sepsis pathology remains unclear.
Ying-Ya Cao, Yuan Zhang, Wuyun Gerile, Yan Guo, Li-Na Wu, Li-Li Wu, Kai Song, Wei-Hua Lu, Jian-Bo Yu   +8 more
doaj   +1 more source

Bone Morphogenetic Protein 4 Alleviates DSS-Induced Ulcerative Colitis Through Activating Intestinal Stem Cell by Target ID3

Frontiers in Cell and Developmental Biology, 2021
Damage to intestinal epithelial cell proliferation or intestinal stem cell (ISC) maintenance may trigger inflammatory bowel disease (IBD), and protecting the ISCs is critical for IBD treatment.
Lei Hu, Lei Hu, Lei Hu, Lei Hu, Junji Xu, Junji Xu, Junji Xu, Junji Xu, Xue Wang, Xue Wang, Liang Feng, Liang Feng, Chunmei Zhang, Chunmei Zhang, Chunmei Zhang, Jinsong Wang, Jinsong Wang, Songlin Wang, Songlin Wang, Songlin Wang   +19 more
doaj   +1 more source

Murine intestinal organoids resemble intestinal epithelium in their microRNA profiles [PDF]

, 2018
Intestinal organoids were established as an ex vivo model of the intestinal epithelium. We investigated whether organoids resemble the intestinal epithelium in their microRNA (miRNA) profiles.
Sonoyama, Kei, Kei Sonoyama (2197510), Kei Sonoyama, Fumina Ohsaka (5186477), Ohsaka, Fumina, Fumina Ohsaka   +5 more
core   +1 more source