Results 21 to 30 of about 263,980 (286)

Glucose sensing in the intestinal epithelium [PDF]

European Journal of Biochemistry, 2003
Dietary sugars regulate expression of the intestinal Na+/glucose cotransporter, SGLT1, in many species. Using sheep intestine as a model, we showed that lumenal monosaccharides, both metabolisable and nonmetabolisable, regulate SGLT1 expression. This regulation occurs not only at the level of transcription, but also at the post‐transcriptional level ...
Jane, Dyer, Steven, Vayro, Timothy P, King, Soraya P, Shirazi-Beechey   +3 more
openaire   +2 more sources

Intestinal epithelial plasticity and regeneration via cell dedifferentiation

Cell Regeneration, 2020
The intestinal epithelium possesses a great capacity of self-renewal under normal homeostatic conditions and of regeneration upon damages. The renewal and regenerative processes are driven by intestinal stem cells (ISCs), which reside at the base of ...
Yuan Liu, Ye-Guang Chen
doaj   +1 more source

The RNA Polymerase III Subunit Polr3b Is Required for the Maintenance of Small Intestinal Crypts in MiceSummary

Cellular and Molecular Gastroenterology and Hepatology, 2016
Background & Aims: The continuously self-renewing mammalian intestinal epithelium, with high cellular turnover, depends on adequate protein synthesis for its proliferative capacity.
Julia E. Kieckhaefer, Sabina Lukovac, Diana Z. Ye, Dolim Lee, Danielle J. Beetler, Michael Pack, Klaus H. Kaestner   +6 more
doaj   +1 more source

Bone Morphogenetic Protein 4 Alleviates DSS-Induced Ulcerative Colitis Through Activating Intestinal Stem Cell by Target ID3

Frontiers in Cell and Developmental Biology, 2021
Damage to intestinal epithelial cell proliferation or intestinal stem cell (ISC) maintenance may trigger inflammatory bowel disease (IBD), and protecting the ISCs is critical for IBD treatment.
Lei Hu, Lei Hu, Lei Hu, Lei Hu, Junji Xu, Junji Xu, Junji Xu, Junji Xu, Xue Wang, Xue Wang, Liang Feng, Liang Feng, Chunmei Zhang, Chunmei Zhang, Chunmei Zhang, Jinsong Wang, Jinsong Wang, Songlin Wang, Songlin Wang, Songlin Wang   +19 more
doaj   +1 more source

Intestinal epithelial-derived TAK1 signaling is essential for cytoprotection against chemical-induced colitis. [PDF]

PLoS ONE, 2009
We have previously reported that intestinal epithelium-specific TAK1 deleted mice exhibit severe inflammation and mortality at postnatal day 1 due to TNF-induced epithelial cell death.
Jae-Young Kim, Rie Kajino-Sakamoto, Emily Omori, Christian Jobin, Jun Ninomiya-Tsuji   +4 more
doaj   +1 more source

Lactobacillus reuteri inhibition of Enteropathogenic Escherichia coli adherence to human intestinal epithelium [PDF]

, 2016
Enteropathogenic Escherichia coli (EPEC) is a major cause of diarrheal infant death in developing countries, and probiotic bacteria have been shown to provide health benefits in gastrointestinal infections.
Bartman, Bernet, Bray, Casas, De Keersmaecker, Etzold, Etzold, Etzold, Forestier, Frese, Havenaar, Jensen, Johansson, Juge, Kim, Knutton, Lanata, Lebeer, Levine, MacKenzie, Miyoshi, Moon, Nataro, Navabi, Ogawa, Oh, Ouwehand, Roos, Savino, Sazawal, Schüller, Servin, Sheng, Sherman, Shornikova, Shornikova, Szajewska, Talarico, Tuomola, Valeur, van Klinken, Viswanathan, Wong   +42 more
core   +2 more sources

The ‘de novo’ DNA methyltransferase Dnmt3b compensates the Dnmt1-deficient intestinal epithelium

eLife, 2016
Dnmt1 is critical for immediate postnatal intestinal development, but is not required for the survival of the adult intestinal epithelium, the only rapidly dividing somatic tissue for which this has been shown.
Ellen N Elliott, Karyn L Sheaffer, Klaus H Kaestner   +2 more
doaj   +1 more source

Neutrophil–Epithelial Crosstalk During Intestinal InflammationSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Neutrophils are the most abundant leukocyte population in the human circulatory system and are rapidly recruited to sites of inflammation. Neutrophils play a multifaceted role in intestinal inflammation, as they contribute to the elimination of invading ...
Le Kang, Xue Fang, Yi-Hang Song, Zi-Xuan He, Zhi-Jie Wang, Shu-Ling Wang, Zhao-Shen Li, Yu Bai   +7 more
doaj   +1 more source

An individual based computational model of intestinal crypt fission and its application to predicting unrestrictive growth of the intestinal epithelium. [PDF]

, 2014
Intestinal crypt fission is a homeostatic phenomenon, observable in healthy adult mucosa, but which also plays a pathological role as the main mode of growth of some intestinal polyps.
A. Patrick Gunning, Aimee Parker, Andreu, Arber, Barker, Barker, Bashir, Berlanga-Acosta, Buczacki, Buske, Buske, Cairnie, Carmen Pin, Cheng, Cheng, Clarke, Clevers, Cummins, Cummins, Dehmer, Dekaney, Drasdo, Drasdo, Dunn, Durand, Edwards, Fauser, Galle, Hannezo, Haramis, Hirata, Humphries, Humphries, Hutter, Ian T. Johnson, Leushacke, Li, Li, Loeffler, Loeffler, Loeffler, Loeffler, Meineke, Milicic, Miyoshi, Nelson, Nelson, Ootani, Osborne, Pin, Pitt-Francis, Potten, Roth, Rothenberg, Sato, Sato, Sato, Sato, Simon R. Carding, Snippert, St Clair, Toshiro Sato, Totafurno, van Es, Wasan, Wong, Wright, Wright, Wright, Yuki Ohta   +69 more
core   +1 more source

Epigenetic regulation of the intestinal epithelium [PDF]

Cellular and Molecular Life Sciences, 2015
The intestinal epithelium is an ideal model system for the study of normal and pathological differentiation processes. The mammalian intestinal epithelium is a single cell layer comprising proliferative crypts and differentiated villi. The crypts contain both proliferating and quiescent stem cell populations that self-renew and produce all the ...
Ellen N, Elliott, Klaus H, Kaestner
openaire   +2 more sources