Results 91 to 100 of about 409,268 (299)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Requirement of Zn to demonstrate HCO3-stimulated ATPase activity of rat small intestinal brush border. [PDF]

, 1979
The existence of a membrane-bound HCO3-stimulated ATPase in intestinal mucosa is controversial. A crude brush border fraction of rat small intestinal homogenates contained HCO3-ATPase activity which was inhibited by preincubation with 3 mM EDTA. Alkaline
Chou, LY, Humphreys, MH, Kaysen, GA
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Long term outcomes of no gut syndrome in children – A multicentre study

Intestinal Failure
Background: Children with extreme short bowel syndrome, including those who have undergone resection of the entire jejunum and ileum—termed ''No Gut Syndrome'' (NGS) in the adult literature—are now surviving due to advancements in parenteral nutrition ...
Elena Cernat, Susan Hill, Rachel Wood, Assad Butt, Sally Buxton, Jeng Cheng, Jenny Goldthorpe, Jonathan Hind, Jutta Koglmeier, Nkem Onyeador, Sue Protheroe, Sunita Rajani, Catherine Richards, Camilla Salvestrini, Chris Smith, Arun Urs, Akshay Batra   +16 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Evolution of gastrostomy tube management in a pediatric intestinal rehabilitation program

Intestinal Failure
Background: Many children with intestinal failure (IF) have gastrostomy tubes (G-tubes) for enteral nutrition. G-tubes are often placed at index admission and not removed until after parenteral nutrition (PN) is weaned off.
Nzuekoh N. Nchinda, Danielle R. Wendel, Patrick J. Javid   +2 more
doaj   +1 more source

Comparison of prevalence and risk factors for faecal carriage of the intestinal spirochaetes Brachyspira aalborgi and Brachyspira pilosicoli in four Australian populations [PDF]

, 2006
This study examined the prevalence of the intestinal spirochaetes Brachyspira aalborgi and Brachyspira pilosicoli in different Western Australian (WA) populations. Faecal samples included 287 from rural patients with gastrointestinal symptoms, comprising
Brooke, C.J., Riley, T.V., Hampson, D.J.
core   +2 more sources

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

p-Cresyl sulfate [PDF]

, 2017
If chronic kidney disease (CKD) is associated with an impairment of kidney function, several uremic solutes are retained. Some of these exert toxic effects, which are called uremic toxins.
Glorieux, Griet, Gryp, Tessa, Vaneechoutte, Mario, Vanholder, Raymond   +3 more
core   +3 more sources

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source