Results 31 to 40 of about 515,539 (267)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway

Frontiers in Cell and Developmental Biology
Background:The COBLL1 gene has been implicated in human central obesity, fasting insulin levels, type 2 diabetes, and blood lipid profiles. However, its molecular mechanisms remain largely unexplored.Methods:In this study, we established cobll1a mutant ...
Ting Zeng, Ting Zeng, Jinrui Lv, Jinrui Lv, Jiaxin Liang, Jiaxin Liang, Binling Xie, Binling Xie, Ling Liu, Ling Liu, Yuanyuan Tan, Yuanyuan Tan, Junwei Zhu, Junwei Zhu, Jifan Jiang, Jifan Jiang, Huaping Xie, Huaping Xie   +17 more
doaj   +1 more source

Effects of dietary energy on growth performance, carcass characteristics, serum biochemical index, and meat quality of female Hu lambs

Animal Nutrition, 2020
This study evaluated the effects of dietary energy levels on growth performance, carcass traits, meat quality, and serum biochemical of female Hu lambs. Seventy female Hu lambs (aged 4 months) were randomly allotted to 5 dietary treatments.
Yancan Wang, Qiye Wang, Chunpeng Dai, Jianzhong Li, Pengfei Huang, Yali Li, Xueqin Ding, Jing Huang, Tarique Hussain, Huansheng Yang   +9 more
doaj   +1 more source

Optimizing individual benefits of pulmonary rehabilitation including a multifaceted dietary intervention – A single-arm feasibility study

Clinical Nutrition Open Science, 2023
Summary: Introduction: Few studies have examined the effectiveness of nutrition interventions in municipal COPD rehabilitation programs. The objectives of this study were to examine the feasibility of implementation in practice (primary) and the ...
A.M. Beck, L. Geisler, S.L. Mikkelsen, H.H. Rasmussen, B.G. Jørgensen, C. Bach-Dal, M. Holst   +6 more
doaj   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

The Hippo Pathway Effector YAP1 Regulates Intestinal Epithelial Cell Differentiation

Cells, 2020
The human intestine is covered by epithelium, which is continuously replaced by new cells provided by stem cells located at the bottom of the glands. The maintenance of intestinal stem cells is supported by a niche which is composed of several signaling ...
Sepideh Fallah, Jean-François Beaulieu
doaj   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Effects of Phytic Acid-Degrading Bacteria on Mineral Element Content in Mice

Frontiers in Microbiology, 2021
Trace minerals are extremely important for balanced nutrition, growth, and development in animals and humans. Phytic acid chelation promotes the use of probiotics in nutrition.
Diao Zhou, Ying Zhao, Jing Li, Vinothkannan Ravichandran, Leli Wang, Qiuyun Huang, Cang Chen, Hengjia Ni, Jia Yin   +8 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source