Results 61 to 70 of about 401,397 (233)

Review article: Intestinal metaplasia and gastric carcinogenesis

, 2002
Gastric intestinal metaplasia, an intermediate step in Correa's cascade of gastric carcinogenesis, is generally regarded as a pre-malignant lesion.
Leung, WK, Sung, JJY
core   +1 more source

PREDICTIVE ROLE OF CDX2, MUC2 AND MUC6 IN PROGRESSION OF CHRONIC GASTRITIS TO CARCINOMA [PDF]

Zagazig University Medical Journal, 2015
Background and aim: The material of this study comprises 57 gastric biopsies including paraffin blocks selected from the archives of Pathology Department, Faculty of medicine, Zagazig University in addition to 10 freshly randomly selected endoscopic ...
Assaf I, El Gohary M, Zaher I, Atwa . A.
doaj   +1 more source

Increased apoptosis in gastric mucosa adjacent to intestinal metaplasia. [PDF]

, 2003
BACKGROUND: The biological processes involved in the development of gastric mucosal atrophy and intestinal metaplasia are still incompletely understood. Reports testing the hypothesis that apoptosis leads to atrophy have yielded conflicting results.
Grieken, N.C.T. van, zur Hausen, A, van Grieken, N.C.T., van Grieken, NC, Meuwissen, SG, Kuipers, Ernst, Meijer, G.A., Kuipers, E.J., Hausen, A zur, Baak, JPA, Baak, J.P.A., Meijer, GA   +11 more
core   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Intestinal Metaplasia of the Stomach

Video Journal and Encyclopedia of GI Endoscopy, 2013
AbstractIntestinal metaplasia (IM) of the stomach is associated with a very small increased risk of developing gastric cancer. Endoscopic surveillance has been proposed and advocated for populations at risk. Risk factors for IM include Helicobacter pylori infection, high salt intake, smoking, alcohol consumption, and chronic bile reflux.
Tang, S-J, Wu, R, Bhaijee, F
openaire   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

A case of Helicobacter pylori-negative early gastric adenocarcinoma with gastrointestinal phenotype

Endoscopy International Open, 2021
A 40-year-old man with slightly depressed (0-IIc) type gastric cancer of the pyloric anterior gastric area underwent pre-operative screening for tetralogy of Fallot and endoscopic submucosal dissection (ESD) and was tested for Helicobacter pylori ...
Masafumi Takatsuna, Rie Azumi, Takeshi Mizusawa, Hiroki Sato, Ken-Ichi Mizuno, Takashi Kato, Junji Yokoyama, Yoichi Ajioka, Shuji Terai   +8 more
doaj   +1 more source

Single‐Cell Transcriptomics and Deep Learning Link N‐(2‐Furoyl) Glycine to GLRX3 in Gastric Cancer

Med Research, EarlyView.
ABSTRACT Gastric cancer remains a health burden, and its metabolic drivers are poorly defined. N‐(2‐furoyl) glycine, a circulating metabolite, has been implicated in tumor biology. We investigated its causal role in gastric cancer and the underlying mechanism.
Yingyi Zhang, Chenchen Wang, Tianliang Liu, Ziliang Wang, Zhe Zhang   +4 more
wiley   +1 more source

Role of Narrow band Imaging (NBI) in Detection of H. Pylori induced gastric intestinal metaplasia in Egyptian patients [PDF]

Al-Azhar International Medical Journal
Background: Helicobacter pylori (H. pylori) colonizes the stomach mucosa of over 50% of the global population. Persistent infection progresses from gastritis to atrophy, intestinal metaplasia, dysplasia, and gastric adenocarcinoma. In Egypt, H.
Ahmed Massoud, Ahmed Ghazy, Ahmed Mohammed, Mohamed Alshahat   +3 more
doaj   +1 more source

Hepatocyte antigen as a marker of intestinal metaplasia

, 2003
Intestinal metaplasia is a histologic hallmark of Barrett\u27s esophagus and chronic gastritis. Intestinal metaplasia may progress to dysplasia or carcinomas without proper treatment.
Chu, Peiguo G., Weiss, Lawrence M., Jiang, Zhong   +2 more
core   +1 more source