Results 71 to 80 of about 40,699 (230)
Risk factors in gastric cancer [PDF]
, 2010 STATE OF THE ART: Gastric cancer (GC) is still a major health problem worldwide due to its frequency, poor prognosis and limited treatment options. At present prevention is likely to be the most effective means of reducing the incidence and mortality ...
COMPARE, DEBORA +2 more
core
VIEW, EarlyView.We created a coculture system using patient‐derived organoids (PDOs) and tumor‐infiltrating lymphocytes (TILs) that mimics important interactions between PDOs and TILs in the presence of various ICIs. Our findings reveal that CD62L+ T cells, activated by CD44+ cancer stem cells (CSCs), facilitate tumor regression in samples sensitive to ICIs, which is ...
Jie Chen +9 more
wiley +1 more source
Amphiregulin-Deficient Mice Develop Spasmolytic Polypeptide Expressing Metaplasia and Intestinal Metaplasia [PDF]
Gastroenterology, 2009 The loss of parietal cells from the fundic mucosa leads to the emergence of metaplastic lineages associated with an increased susceptibility to neoplastic transformation. Both intestinal metaplasia (IM) and spasmolytic polypeptide (TFF2/SP) expressing metaplasia (SPEM) have been identified in human stomach, but only SPEM is present in most mouse models
Ki Taek, Nam +6 more
openaire +3 more sources
Role of transcription factor Cdx2 in the development of gastric intestinal metaplasia
Patologìâ, 2012 The role of intestinal differentiation transcription factor Cdx2 in the development of gastric intestinal metaplasia was established on the basis of its expression in material of gastric mucosa biopsies.
S. V. Vernygorodskiy, L. V. Degtyaryova
doaj +1 more source
VIEW, EarlyView.PHF1 is a known epigenetic regulator involved in transcriptional silencing in cancer. In this study, we identified PHF1 as an oncogene that promotes PDAC progression and demonstrated that its inhibition induces ferroptosis. Mechanistically, PHF1 physically interacts with the FBL/NOP56/NOP58 snoRNP complex to enhance the IRES‐dependent translation of ...
Yujiao Xie +9 more
wiley +1 more source
Endoscopic Classification of Intestinal Metaplasia [PDF]
The Korean Journal of Helicobacter and Upper Gastrointestinal Research, 2013 Intestinal metaplasia (IM) is recognized as a precancerous condition for intestinal type gastric cancer. Therefore, endoscopic diagnosis of IM is valuable for patients undergoing surveillance endoscopy. However, there are no standard endoscopic findings that distinguish it from the normal mucosa.
Byoung Wook Bang, Hyung Gil Kim
openaire +1 more source
The esophagogastric junctional adenocarcinoma an increasing disease [PDF]
, 2017 Identifying and defining the esophagogastric junctional adenocarcinoma (EGJA) as an independent disease apart from gastric cancer (GC) and esophagus cancer (EG) it has always been a difficult issue entailing doubts about the appropriate therapeutic ...
Andreetti, Claudio +3 more
core +1 more source
Murine Models of Gastric Corpus PreneoplasiaSummary
Cellular and Molecular Gastroenterology and Hepatology, 2017 Intestinal-type gastric adenocarcinoma evolves in a field of pre-existing metaplasia. Over the past 20 years, a number of murine models have been developed to address aspects of the physiology and pathophysiology of metaplasia induction. Although none of
Christine P. Petersen +2 more
doaj +1 more source
Gaceta Sanitaria, 2008 Although the pathogenesis of intestinal metaplasia remains unknown1, it is well recognized that chronic gastritis and intestinal metaplasia are precursor conditions of gastric cancer.
Carlos A. González
doaj +5 more sources
Plasticity of differentiated cells in wound repair and tumorigenesis, Part II: Skin and intestine [PDF]
, 2018 Recent studies have identified and begun to characterize the roles of regenerative cellular plasticity in many organs. In Part I of our two-part Review, we discussed how cells reprogram following injury to the stomach and pancreas.
Burclaff, Joseph, Mills, Jason C
core +2 more sources