Results 51 to 60 of about 361,975 (346)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Histopathological changes of chronic cestodes infection in local domesticated ducks (Anas platyrhynchas) in Baghdad city.

The Iraqi Journal of Veterinary Medicine, 2019
This study was conducted to investigate the histopathological changes of cestodes chronic intestinal infections in ten local domesticated ducks (Anas platyrhynchas) during the period 1/9/2016- 1/10/2017 in Baghdad city.
Haider Mohammed Ali Al-Rubaie
doaj   +1 more source

Postprandial morphological response of the intestinal epithelium of the Burmese python (Python molurus)

, 2006
The postprandial morphological changes of the intestinal epithelium of Burmese pythons were examined using fasting pythons and at eight time points after feeding.
Aldewachi, Carey, Carey, Cramp, Cécile Helmstetter, Diamond, Diaz, Dunel-Erb, Garcia Hernandez, Gershon, Goodlad, Greene, Hammond, Heyman, Hume, Jean-Hervé Lignot, Johnson, Lignot, McLeese, Noaillac-Depeyre, Noaillac-Depeyre, Piersma, Pope, Rodewald, Secor, Secor, Secor, Secor, Secor, Secor, Secor, Secor, Secor, Sire, Solomon, Starck, Stephen M. Secor, Walker, Walsh, Weaver, Weinman   +40 more
core   +1 more source

Histopathology of the gut in rheumatic diseases [PDF]

, 2018
The gastrointestinal tract regulates the trafficking of macromolecules between the environment and the host through an epithelial barrier mechanism and is an important part of the immune system controlling the equilibrium between tolerance and immunity ...
Ciccia F., Ferrante A., Guggino G., Macaluso F., Rizzo A.   +4 more
core   +1 more source

Identification of amino acids essential for angulin‐1/3 binding of the tricellular tight junction binder, angubindin‐1

FEBS Open Bio, EarlyView.
Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu, Yumi Iwashita, Keisuke Tachibana, Itsuki Nishino, Yuki Niwa, Atsuko Uyeda, Kazuki Matsuo, Masahiro Nagahama, Masuo Kondoh   +8 more
wiley   +1 more source

Lactobacillus salivarius reverse antibiotic-induced lung defense impairment in a ventilator model

Journal of Translational Medicine, 2018
Background Widespread use of antibiotics in the intensive care unit is a potential cause of the emergence of hospital-acquired pneumonia. This study determined whether Lactobacillus salivarius feeding could reverse antibiotic-induced lung defense ...
Tzyy-Bin Tsay, Ming-Chieh Yang, Wan-Hsuan Chang, Pei-Hsuan Chen, Lee-Wei Chen   +4 more
doaj   +1 more source

The pathologists’ eyes on foregut: histopathological relations in the experimental and routine diagnostics [PDF]

, 2011
SUMMARY I. The study aimed to investigate the incidence of duodeno-gastroesophageal reflux-induced malignoma formation in a series of duodeno-esophageal anastomosis operations in rats.
Németh István Balázs
core  

Is rejection a diffuse or localized process in small-bowel transplantation? [PDF]

, 1994
Utilization of endoscopy to both visualize and selectively biopsy an intestinal allograft has become the standard for early recognition and treatment of intestinal allograft rejection.
A Jain, A. Gurakar, B Banner, CC Inshan Clark, D. H. Van Thiel, E. Frezza, H. I. Wright, K Abu-Elmagd, K Nakamura, K Nakamura, KM Abu-Elmagd, M. Balkan, P Schroeder, S Todo, S Todo, S Todo, S Todo, S. Fagiuoli, S. Todo, T. E. Starzl, T. Hassanein   +20 more
core   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Sodium chloride transport of normal and dietary enlarged rat cecum in vitro [PDF]

, 1998
Sodium chloride transport across isolated cecum mucosa was investigated in normal rats and rats with adaptive cecum growth induced by dietary polyethylene glycol (PEG). The normal cecum absorbed CI in excess of Na with a small short-circuit current (Isc).
Loeschke, Klaus, Schreiner, Josefine, Weber, Matthias   +2 more
core   +1 more source