Results 91 to 100 of about 86,263 (270)

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Protective effect of periplaneta americana extract on intestinal mucosal barrier function in patients with sepsis

, 2013
ObjectiveTo investigate the effect of the periplaneta americana extract on the intestinal mucosal barrier and prognostic implications in patients with sepsis.MethodsSixty and six patients with sepsis were assigned randomly to treatment group (32 cases ...
Zhang, Zhenyu, Zhang, Jing, Liu, Shuzheng, Hu, Yanling, Zhang, Hongwei, Wei, Liyou, Zhao, Gang   +6 more
core   +1 more source

Dietary emodin alleviates lipopolysaccharide-induced intestinal mucosal barrier injury by regulating gut microbiota in piglets

, 2023
This study was to determine the effects of dietary emodin (ED) on the intestinal mucosal barrier, nuclear factor kappa-B (NF-κB) pathways, and gut microbial flora in lipopolysaccharide (LPS)-induced piglets.
Liguang Shi, Mengyao Ji, Tanjie Deng, Wenjuan Xun, Guanyu Hou, Zhonghua Ma, Wen Yang, Ting Cao   +7 more
core   +1 more source

Diagnostic study of serum claudin-3 and zonulin for intestinal barrier dysfunction after abdominal surgery

Frontiers in Medicine
BackgroundPrevious studies have shown that serum claudin-3 and zonulin play important roles in reflecting intestinal barrier function. This study aims to explore the diagnostic value of serum claudin-3 and zonulin in assessing intestinal barrier ...
YiChen Hu, WenShuo Liu, XueJing Gong, FuQiong Jiang, Jie Huang, YuanPei Zhao, WeiMing Li   +6 more
doaj   +1 more source

IL‐7R‐Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao, Yuheng Liu, Ruibing Yang, Zifeng Zhu, Junwei Wu, Dinghao Li, Jin Su, Yingxin He, Shiqi Luo, Feiyang Cao, Haiyi Deng, Lanmengxi Yang, Ling Zhong, Peiying Peng, Xinyi Wu, Chunmei Cai, Zhen Li, Yujin Wu, Shuofeng Zhu, Jie Wei, Yi Yang, Lifu Wang   +21 more
wiley   +1 more source

Supplementary Material for: Lafutidine Ameliorates Indomethacin-induced Small Intestinal Damage in Rats by Modifying the Intestinal Mucosal Barrier, Inflammation, and Microbiota

, 2023
Introduction: Nonsteroidal anti-inflammatory drug (NSAID)-induced small intestinal damage is a serious and escalating clinical problem without effective treatment.
Zhu L. (2945931), Chen X. (2888087), Xu X. (2878946), Luo Y. (4147609), Zhao J. (3610445), Liang H. (4135681), Liu Q. (3341049), Chen J. (2954172), Guo J. (4144114), Song C. (11712152), Wang B. (4026758), Lou C. (14827510), Sun S. (3610586), Zhong W. (11704490)   +13 more
core   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Image_1_Responses of Intestinal Mucosal Barrier Functions of Rats to Simulated Weightlessness.JPEG

, 2018
Exposure to microgravity or weightlessness leads to various adaptive and pathophysiological alterations in digestive structures and physiology. The current study was carried out to investigate responses of intestinal mucosal barrier functions to ...
Mingliang Jin (1943671), Chunlan Xu (610985), Junling Shi (791247), Ke Zhao (248186), Qingsheng Huang (357131), Dongyan Shao (791251), Hui Yang (91136), Hao Zhang (15339)   +7 more
core   +1 more source

Potent Intestinal Mucosal Barrier Enhancement of Nostoc commune Vaucher Polysaccharide Supplementation Ameliorates Acute Ulcerative Colitis in Mice Mediated by Gut Microbiota

, 2023
Ulcerative colitis (UC) is evolving into a global burden with a substantially increasing incidence in developing countries. It is characterized by inflammation confined to mucosa and is recognized as an intestinal barrier disease.
Jin Wang, Zhuoyu Li, Ying Zhang, Min Guo, Dehai Xing, Xiangying Jiao   +5 more
core   +1 more source

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source