Results 81 to 90 of about 86,263 (270)

Changes in intestinal mucosal immune barrier in rats withendotoxemia

World Journal of Gastroenterology, 2009
To investigate the dysfunction of the immunological barrier of the intestinal mucosa during endotoxemia and to elucidate the potential mechanism of this dysfunction.Male Wistar rats were randomly distributed into two groups: control group and lipopolysaccharide (LPS) group. Endotoxemia was induced by a single caudal venous injection of LPS.
Chong, Liu, Ang, Li, Yi-Bing, Weng, Mei-Li, Duan, Bao-En, Wang, Shu-Wen, Zhang   +5 more
openaire   +2 more sources

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Identification of a Peptide Sequence That Improves Transport of Macromolecules Across the Intestinal Mucosal Barrier Targeting Goblet Cells

, 2008
In this study, we demonstrated that the CSKSSDYQC-peptide ligand which was identified from a random phage-peptide library through an in vivo phage display technique with rats could prominently improve the transport efficiency of macromolecules, such as ...
Kim, Min Kook, Choi, Yun Jaie, Woo, Jung Hee, Woo, Sang Soo, Choi, Jin Hyuk, Kang, Sang, Lee, Nam Kyung, Lee, Hong Gu   +7 more
core   +1 more source

Effects of chronic renal failure on intestinal mucosal barrier and expression of autophagy related proteins in rats

, 2022
Objective To observe the injury of intestinal mucosal barrier and the expression of autophagy protein in colon tissue of rats with chronic renal failure.
ZHANG Zi-yuan, FANG Jing-ai, LI Su-fen, HU Ya-ling, ZHANG Xiao-dong, LIU Wen-yuan, LIU Xue-jun
core   +1 more source

Malvidin-3-O-galactoside ameliorates small intestinal mucosal barrier function via Notch pathway

Food Science and Human Wellness
The intestinal mucosa is the intestinal lumen tissue that protects the intestine from invasion, maintains intestinal barrier function, and participates in the immune response.
Yuehua Wang, Ying Zhang, Bo Zhang, Jiaying Zhang, Hui Tan, Li Li, Xinyao Jiao   +6 more
doaj   +1 more source

Research Advance in Intestinal Mucosal Barrier and Pathogenesis of Crohn’s Disease [PDF]

Gastroenterology Research and Practice, 2016
To date, the etiology and pathogenesis of Crohn’s disease (CD) have not been fully elucidated. It is widely accepted that genetic, immune, and environment factors are closely related to the development of CD. As an important defensive line for human body against the environment, intestinal mucosa is able to protect the homeostasis of gut bacteria and ...
Kuan Wang, Lu-yi Wu, Chuan-zi Dou, Xin Guan, Huan-gan Wu, Hui-rong Liu   +5 more
openaire   +3 more sources

Biomimetic Ru‐Mn Nanozyme with Cascade Catalytic Activity Attenuates Secondary Brain Injury in Intracerebral Hemorrhage

Advanced Science, EarlyView.
Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan, Peng Li, Yue Wang, Xin Qi, Wanyu Wang, Yongzhong Cheng, Huabin Zhang, Xin Hu, Xiang Gao   +8 more
wiley   +1 more source

Responses of Intestinal Mucosal Barrier Functions of Rats to Simulated Weightlessness

, 2018
Exposure to microgravity or weightlessness leads to various adaptive and pathophysiological alterations in digestive structures and physiology. The current study was carried out to investigate responses of intestinal mucosal barrier functions to ...
Hui Yang, Chunlan Xu, Hao Zhang, Ke Zhao, Mingliang Jin, Dongyan Shao, Junling Shi, Qingsheng Huang   +7 more
core   +1 more source

MitoQ Modulates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction via Regulating Nrf2 Signaling

Mediators of Inflammation, 2020
Background. Gut barrier dysfunction with alterant mucosal permeability during sepsis is a challenge problem in clinical practice. Intestinal epithelial cells (IECs) are strongly involved in mucosal oxidative stress and inflammatory response.
Shengfeng Zhang, Qingniao Zhou, Youcheng Li, Yunli Zhang, Yinmei Wu   +4 more
doaj   +1 more source

Deoxycholic acid disrupts the intestinal mucosal barrier and promotes intestinal tumorigenesis

Food & Function, 2018
Deoxycholic acid (DCA) induced intestinal low grade inflammation and disrupted the mucosal physical and functional barriers, aggravating intestinal tumorigenesis.
Li Liu, Wenxiao Dong, Sinan Wang, Yujie Zhang, Tianyu Liu, Runxiang Xie, Bangmao Wang, Hailong Cao   +7 more
openaire   +3 more sources