Results 61 to 70 of about 86,263 (270)

Activation of notch signaling pathway is a potential mechanism for mucin2 reduction and intestinal mucosal barrier dysfunction in high-altitude hypoxia. [PDF]

Sci Rep
High-altitude hypoxia can cause gastrointestinal issues and damage the intestinal mucosal barrier, which is crucial for digestion and nutrient absorption. The Notch signaling pathway affects this barrier’s integrity. This study explores the Notch pathway’
Jia R, Han Y, Zhu Q, Zhang J, Zhang H, Ka M, Ma Y, Gamah M, Zhang W.   +8 more
europepmc   +2 more sources

Myrcene‐Based Tailored Co‐Polymers as Active Pharmaceutical Excipients: Bio‐Based Solutions for Mucoadhesive Excipients

Advanced Functional Materials, EarlyView.
Mucoadhesive amphiphilic block and statistical copolymers were synthesized via Reversible Addition–Fragmentation Chain Transfer polymerization from bio‐sourced myrcene and polyethylene glycol methacrylate. The resulting polymers exhibit narrow molar‐mass distributions, high regioselectivity, well‐defined microstructures, and tend to self‐assemble into ...
David Gintsburg, Selin Görkem Sari, Lana Molnar, Annabelle Knoll, Effrosyni‐Maria Kosti, Anna Seybold, Gozde Deveci, Nico Bruns, Andreas Bernkop‐Schnürch, Gergely Kali   +9 more
wiley   +1 more source

Numb mitigates intestinal epithelial cell senescence induced by radiation through a PLK1-dependent pathway

Scientific Reports
Radiation-induced senescence of intestinal epithelial cells plays a crucial role in damaging the intestinal mucosal barrier. Previous studies have implicated Numb in regulating intestinal mucosal barrier homeostasis, while Polo-like kinase 1 (Plk1 ...
Yongtao Yang, Xiao Hu, Yuwei Pan, Wen Ji, Tao Liu, Xi Zheng   +5 more
doaj   +1 more source

Mechanisms of action and applications of Polygonatum sibiricum polysaccharide at the intestinal mucosa barrier: a review

Frontiers in Pharmacology
As a medicinal and edible homologous Chinese herb, Polygonatum sibiricum has been used as a primary ingredient in various functional and medicinal products. Damage to the intestinal mucosal barrier can lead to or worsen conditions such as type 2 diabetes
Yu Ren, Yu Ren, Yi Sun, Yu-Ying Liao, Si Wang, Si Wang, Qian Liu, Chun-Yan Duan, Lan Sun, Xiao-Ya Li, Jia-Li Yuan   +10 more
doaj   +1 more source

Mechanism‐Driven Nanoformulations for Cognitive Impairment Induced by Intermittent Hypoxia and Periodontitis

Advanced Materials, EarlyView.
Clinically, intermittent hypoxia (IH) is often accompanied by periodontitis, which accelerates cognitive impairment induced by IH. Novel Janus mesoporous gold‐silica nanoformulations (RVG‐Au&mSiO2‐TPP‐VB) enable intranasal delivery, achieve hierarchical targeting to neuronal mitochondria, effectively scavenge reactive oxygen species, inhibit the HIF‐1α/
Kai‐Run Zhang, Tianbao Zhu, An‐Qi Liu, Jia‐Jia Deng, Ya‐Li Han, Sheng‐Cai Qi, Xue Liu, Tian‐Yi Jiang, Ming‐Rui Zhai, Yu‐Ying He, Xiu‐Juan Li, Hong‐Ting Da, Rui Xu, Xiaomin Li, Jun Gao, Yue‐Hua Liu   +15 more
wiley   +1 more source

Research progress on intestinal mucosal barrier function， injury mechanism and nutritional regulation of fish

Siliao yanjiu, 2023
The intestine is an important organ for nutrient absorption and digestion of the body, and the intestinal mucosal barrier also plays an indispensable role.
LI Xu-nan, CHEN Xiu-mei, PENG Si-bo, LIN Yun-jie, JIN Xiao-yan, SUN Jia-xin, WANG Gui-qin   +6 more
doaj  

Estrogen deficiency aggravates fluoride-induced small intestinal mucosa damage and junctional complexes proteins expression disorder in rats

Ecotoxicology and Environmental Safety, 2022
To investigate the effect of estrogen deficiency on the small intestinal mucosal barrier induced by fluoride (F), F exposure models of ovariectomy (OVX) rats (surgically removed ovaries) and non-OVX rats (normal condition) were established by adding ...
Ye Jin, Xiao-ying Gao, Jing Zhao, Wei-shun Tian, Yu-ling Zhang, Er-jie Tian, Bian-hua Zhou, Hong-wei Wang   +7 more
doaj   +1 more source

An Imaging‐Guided, Patient‐Specific Guiding Aid (RWNGuide) for Safe and Reproducible Inner Ear Drug Delivery

Advanced Materials Technologies, EarlyView.
A patient‐specific, imaging‐guided aid enables precise and reproducible drug delivery to the inner ear. By guiding therapeutic agents directly to the round window niche, this approach reduces variability in drug localization, improves delivery safety, and addresses a critical bottleneck in inner ear therapy, offering a scalable strategy for precision ...
Yanjing Luo, Shanshan Jiang, Yimian Luo, Adele Moatti, Farnaz Matin‐Mann   +4 more
wiley   +1 more source

Table1_Ammonia nitrogen stress damages the intestinal mucosal barrier of yellow catfish (Pelteobagrus fulvidraco) and induces intestinal inflammation.DOCX

, 2023
Nitrogen from ammonia is one of the most common pollutants toxics to aquatic species in aquatic environment. The intestinal mucosa is one of the key mucosal defenses of aquatic species, and the accumulation of ammonia nitrogen in water environment will ...
Yongqiang Deng, Liang Zhong, Fengyuan Zuo, Senyue Liu (13524919), Sha Liu, Yangping Ou, Yangping Ou (6520988), Xiaoli Huang (309237), Senyue Liu, Defang Chen (8116916), Lin Luo (429475), Wenlong Cai (3206064), Yi Geng (1467373), Lin Luo, Liang Zhong (402998), Fengyuan Zuo (13524922), Sha Liu (80416), Yongqiang Deng (540280), Xiaoli Huang, Yi Geng, Defang Chen, Wenlong Cai   +21 more
core   +1 more source

The Microbiome Activates CD4 T-cell–mediated Immunity to Compensate for Increased Intestinal PermeabilitySummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: Despite a prominent association, chronic intestinal barrier loss is insufficient to induce disease in human subjects or experimental animals.
Karen L. Edelblum, Gil Sharon, Gurminder Singh, Matthew A. Odenwald, Anne Sailer, Severine Cao, Sarina Ravens, Irene Thomsen, Kamal El Bissati, Rima McLeod, Chen Dong, Sandeep Gurbuxani, Immo Prinz, Sarkis K. Mazmanian, Jerrold R. Turner   +14 more
doaj   +1 more source